Skip to main content

Exploring the feasibility and acceptability of a mixed-methods pilot randomized controlled trial testing a 12-week physical activity intervention with adolescent and young adult cancer survivors

Abstract

Background

Adolescent and young adult (AYA) cancer survivors (i.e. individuals diagnosed with cancer between 15 and 39 years and who completed treatment) may benefit from physical activity. Yet, few researchers have explored the effects of physical activity on physical and psychological outcomes among AYA cancer survivors. A pilot study exploring the feasibility and acceptability of a physical activity intervention and proposed trial methods to inform a definitive randomized controlled trial (RCT) is therefore necessary to fill this gap.

Methods

A two-arm, mixed-methods pilot RCT was conducted. Participants were randomized to a wait-list control group or a 12-week physical activity intervention comprised of 4 weekly aerobic and strength training sessions (intervention group). Feasibility measures included: number of AYA cancer survivors referred/self-referred, eligible, and recruited, retention to the trial (i.e. assessment completion), adherence to the physical activity intervention, and percentage of missing data for baseline (week 0), mid- (week 6), and post-intervention assessments (week 12). The acceptability of trial methods (all participants) and the intervention (intervention group only) was assessed via qualitative interviews post-intervention.

Results

Over a 12-month period, 31 AYA cancer survivors were referred/self-referred and 16 were eligible and consented to participate. Retention to the trial was 94% and adherence to the physical activity intervention ranged from 50 to 92%. With the exception of the assessment of aerobic capacity and directly measured physical activity behaviour, there were no missing data. Participants generally reported being satisfied with the trial methods and intervention; however, issues related to delivery of the physical activity intervention were identified.

Conclusions

The methods and intervention piloted require modification and further pilot testing in advance of a definitive RCT. Recruitment strategies identifying a greater number of younger AYA cancer survivors who have different types of cancers and who lack motivation to participate in physical activity-based studies should be explored. Refining the assessments of directly measured physical activity behaviour and aerobic capacity and incorporating behavioural support into the intervention may improve feasibility and acceptability. This study highlights the value of doing pilot work and provides critically useful data that can be used to refine studies seeking to assess causation and optimize physical activity interventions for AYA cancer survivors.

Trial registration

clinicaltrials.gov, NCT03016728. Registered January 11, 2017.

Peer Review reports

Background

Adolescent and young adult (AYA) cancer survivors (i.e. individuals diagnosed with cancer between the ages of 15 and 39 years who have completed treatment [1]) face a range of negative physical (e.g. body composition changes, disfigurement, tissue damage, morbidity, premature mortality) and psychological effects (e.g. reduced self-esteem, lowered quality of life, anxiety [2,3,4]). Though these adverse effects are reported regardless of age at diagnosis, researchers have found that AYA cancer survivors experience a greater symptom burden than their older counterparts diagnosed with similar cancers [5,6,7]. This is due, in part, to the transitional period AYA cancer survivors are in when diagnosed that necessitates managing cancer and its effects while navigating critical developmental milestones (e.g. moving from childhood to adulthood physically, psychologically, socially, financially, and educationally [8]). Given AYA cancer survivors’ age at diagnosis and the subsequent number of life-years affected by cancer-related sequelae, minimizing the negative impact for this population while promoting longevity has been identified as a priority [9, 10]. Despite this, few interventions that have the potential to promote length and quality of life have been developed, implemented, and evaluated with AYA cancer survivors.

Physical activity for AYA cancer survivors

There is considerable evidence from experimental studies showing that participation in physical activity yields numerous physical and psychological health benefits for adult cancer survivors [11,12,13]. Commonly reported benefits include improved muscular strength and endurance, aerobic capacity, physical functioning, mood, self-esteem, and quality of life [11,12,13]. As such, many researchers have begun to explore the role of physical activity for AYA cancer survivors. Early evidence suggests physical activity is associated with a range of physical and psychological benefits, similar to those reported among older adult cancer survivors [14, 15]. Notwithstanding the contributions from these studies, the collective body of research has limitations. Specifically, researchers have typically assessed a narrow range of outcomes with homogenous samples and have primarily used cross-sectional study designs grounded in the positivist paradigm [16]. There is a need for research that incorporates a range of physical and psychological outcomes, adopts longitudinal or intervention study designs, and utilizes different paradigms (e.g. interpretivist [17,18,19]). As well, potential mediators and moderators of the relationship between physical activity and physical and psychological outcomes remain under explored [17,18,19], which prevents an understanding of how physical activity might be beneficial and under what circumstances desired outcomes may be maximized for this population.

Mediators and moderators of the relationship between physical activity and physical and psychological outcomes

Identifying the mechanisms through which physical activity exerts its benefits can provide researchers with meaningful targets to optimize intervention effects. The exercise and self-esteem model (EXSEM [20]) has been used to achieve these aims and test how physical activity impacts physical and psychological outcomes in samples drawn from the general population [21, 22]. Within the EXSEM, Sonstroem and Morgan [20] suggest that participating in physical activity leads to changes in one’s physical fitness (i.e. physical measures such as weight status, muscular strength and endurance, aerobic capacity, etc.) and self-efficacy (i.e. confidence regarding one’s ability to successfully engage in physical activity). Improved physical fitness and self-efficacy then lead to improved physical self-perceptions (i.e. self-evaluation of one’s overall physical condition and fitness), which enhances physical self-esteem (i.e. subjective evaluation of the function and appearance of one’s body) and subsequently global self-esteem (i.e. subjective evaluation of one’s self-worth). Among older breast cancer survivors, physical fitness, self-efficacy, and physical self-perceptions have been shown to mediate the relationships between physical activity and physical and global self-esteem [23,24,25]. Based on research showing that AYA cancer survivors who are more active report greater self-esteem [26, 27] and that participating in physical activity may positively impact one’s self-efficacy [28] and appearance satisfaction [29], there is reason to believe that these findings may extend to AYA cancer survivors. Moderation hypotheses can also be drawn based on a cross-sectional study that found that self-efficacy for physical activity interacted with physical self-perceptions to promote psychological outcomes among AYA cancer survivors [30]. However, the mediators and moderators embedded within the EXSEM remain untested with AYA cancer survivors in trials using experimental designs. Studies testing outcomes of physical activity interventions among AYA cancer survivors and exploring mediators and moderators could generate useful information to guide physical activity recommendations and identify targets for future physical activity interventions seeking to promote physical and psychological outcomes in this cohort.

The continuum of evidence

Though a definitive randomized controlled trial (RCT) is warranted to address questions of causation and elucidate mechanisms, it is not indicated at this time [31]. This is because there is a lack of research exploring the effects of physical activity interventions delivered in-person (i.e. face-to-face) to AYA cancer survivors. As a result, markers of feasibility (e.g. recruitment, retention, adherence) and acceptability (e.g. satisfaction with trial methods and intervention components) remain unknown. Moreover, there is little information regarding recruitment, retention, and adherence metrics for physical activity research in this population. Collecting this information is vital to conserve valuable research resources and enhance the likelihood of successful definitive RCTs [31, 32]. Following the continuum of evidence put forth by Campbell et al. [31], a pilot RCT is the necessary next step towards examining if and how physical activity improves physical and psychological outcomes among AYA cancer survivors.

Current study

A two-arm, mixed-methods RCT was developed to test the effects of a 12-week physical activity intervention. To lay the foundation for a future definitive RCT, a pilot RCT assessing the feasibility (defined as recruitment over a 12-month period, retention, adherence, and completeness of data) and acceptability (defined as satisfaction) of trial methods (e.g. randomization, procedures) and the intervention (e.g. intervention delivery) was required.

Methods

Study design

This study was a two-arm, mixed-methods pilot RCT designed to test a 12-week physical activity intervention on a range of physical and psychological outcomes among AYA cancer survivors. The protocol was registered in the ClinicalTrials.gov database (NCT03016728), and was approved by the Ottawa Health Science Network, Children’s Hospital of Eastern Ontario, University of Ottawa, and Royal Ottawa Mental Health Centre Research Ethics Boards. The reporting standards for pilot trials put forward by Consolidated Standards of Reporting Trials (CONSORT [33]) were followed in the preparation of this manuscript (see Additional file 1).

Sample

The target sample consisted of AYA cancer survivors who: (1) were diagnosed with cancer between the ages of 15 and 39 years; (2) had completed cancer treatment within the past 5 years; (3) showed no evidence of progressive or recurrent disease or of secondary or second cancers; (4) were inactive or insufficiently active (assessed using a single-item screening question: ‘Are you currently engaging in moderate physical activity, that is activity that increases your heart rate and causes you to sweat, > 3 days/week?’); (5) were medically cleared to participate in physical activityFootnote 1; and (6) were able to read, understand, and provide informed consent in English. AYA cancer survivors were not eligible if they: (1) had physical impairments precluding participation in physical activity and/or (2) were unwilling or unable to provide informed consent.

Procedures

AYA cancer survivors were recruited across a 12-month period starting in September 2017 through healthcare provider referral (wherein eligible AYA cancer survivors were first screened and then approached by their healthcare provider to obtain consent for the first author to contact) and snowball sampling (wherein potentially eligible AYA cancer survivors self-screened and then contacted the first author). A 12-month period was specified a priori so as to capture seasonal variation that may affect trial and intervention feasibility and/or acceptability, and thus better inform the timeline for a definitive RCT. Following confirmation of eligibility and obtaining informed consent, participants completed a baseline assessment (week 0) comprised of physical tests, a survey, a qualitative interview, and wearing an accelerometer for 7 consecutive days. Afterwards, participants were randomly assigned to either the intervention or wait-list control group by an independent researcher who used a web-based random number generator. Participants completed mid- (week 6) and post-intervention assessments (week 12), which resembled the baseline assessment. All assessments were conducted by the first author at a private location of participants’ choosing. At study cessation participants were entered into a draw to win a $250 gift card, regardless of retention to the trial and/or adherence to the intervention.

Physical activity intervention

The physical activity intervention was developed across a 6-month period. Intervention components were first selected based on recent systematic reviews [11,12,13, 34, 35], clinical guidelines [36], physical activity recommendations [37], behaviour change literature [38,39,40], and population-specific preferences for physical activity [41,42,43,44]. This was augmented by eliciting opinions from an advisory board comprised of three AYA cancer survivors (who met the eligibility criteria outlined above), three allied healthcare providers (n = 1 Kinesiologist; n = 2 Certified Exercise Physiologists), and two oncologists. The result was a 12-week physical activity intervention using a pragmatic approach, wherein flexibility was prioritized to minimize participant burden.

Participants assigned to the intervention group received a 12-week individualized physical activity program and were lent equipment for weeks 1–12 (i.e. hand weights, resistance bands). They were also provided with a fitness bag that had a water bottle, socks, sweat towel, and yoga mat to minimize barriers related to access. Participants could keep the bag and its contents post-intervention. The program consisted of 4 weekly sessions lasting for 25–45 min/session (see Table 1 for an overview). Two of these sessions focused on strength activities and were supervised by the first authorFootnote 2 for weeks 1–6 (e.g. squats, lunges, shoulder press, bicep curls). During these sessions, participants were taught proper form and technique and were provided rationale for each intervention component to enhance their knowledge. They were also offered various modifications and supported in choosing intensities that were right for them to enhance their feelings of confidence and competence. Based on participants’ preferences, sessions took place at participants’ home (n = 40 sessions), a local cancer survivorship centre (n = 15 sessions), or the University of Ottawa (n = 4 sessions). In weeks 7–12, participants were instructed to continue engaging in strength training two times/week unsupervised. Throughout weeks 1–12, participants were asked to participate in two unsupervised sessions/week focused on aerobic activities (e.g. walking, rowing, indoor/outdoor bicycling, jogging) between 40 and 75% of their estimated heart rate reserve. Participants were provided with a Polar A300 activity monitor with a heart rate strap and taught how to use a 10-point Perceived Exertion Scale as a means of verifying aerobic session prescription and teaching them how to self-monitor. The volume and intensity of each aerobic and strength training session were modifiable depending on how participants felt that day and was progressed over the course of the 12-week intervention on an individual basis so as to ensure participants experienced success with the program while acquiring new skills.

Table 1 Overview of the 12-week physical activity program

Wait-list control group

Participants assigned to the wait-list control group were advised to continue with their usual routine for weeks 1–12. After their post-intervention assessment (week 12), participants received the same 12-week intervention, materials, and equipment as the intervention group.

Measures

Feasibility (throughout the trial)

To assess feasibility, the number of AYA cancer survivors referred, eligible, recruited/not recruited (reasons for non-recruitment), retention to the trial, adherence to the physical activity intervention, and percentage of missing data were collected. Source of referrals were tracked and recruitment rate was defined as the number of eligible participants who enrolled in the trial out of the number of eligible AYA cancer survivors who self-referred or were referred. Retention rate was defined as the number of participants completing all three assessments. Adherence rates were defined as the number of supervised strength sessions engaged in out of 12 (weeks 1–6), unsupervised strength sessions engaged in out of 12 (weeks 1–6), and unsupervised aerobic sessions engaged in out of 24 (weeks 1–12). To collect this information, participants in the intervention group completed weekly physical activity logbooks across weeks 1–12. Completeness of quantitative data and participation in interviews were also examined. Missingness was defined as percentage of missing data on each measure and overall.

As recommended for pilot studies [32, 45], a priori targets for each feasibility outcome were set using relevant literature [46,47,48,49] and the authors’ own clinical experience: (1) 36–48 AYAs referred/self-referred over 12 months, (2) > 70% of eligible AYA cancer survivors agree to be enrolled, (3) ≥ 75% of participants complete baseline, mid- and post-intervention assessments, (4) each participant assigned to the intervention group completes > 75% of the prescribed physical activity intervention, and (5) < 10% missing data overall.

Acceptability (week 12)

All participants answered questions related to the acceptability of trial methods (e.g. satisfaction with randomization, assessments, procedures) at their post-intervention assessment (week 12). For those in the intervention group, this was commensurate with when they finished the intervention. For those in the wait-list control group, this was commensurate with the end of their 12-week waiting period (before they received the intervention). Additional questions related to intervention acceptability (e.g. satisfaction with intervention components [delivery, modality, length, duration]) were asked to participants in the intervention group only at their post-intervention assessment (week 12).

Adverse event monitoring (throughout the trial)

Participants’ were instructed to self-report adverse events to the first author who had a standardized reporting form (e.g. date, severity, timing, site/location, duration, clinical action taken, outcome). None were reported.

Personal and medical factors (week 0)

Participants self-reported a range of personal (i.e. age, sex, annual household income, education attainment, school/work status) and medical factors (i.e. cancer diagnosis, treatment protocol, time since treatment, co-morbid conditions), which were used as a means of describing the sample and for tailoring/individualizing participants’ physical activity intervention.

Physical activity behaviour (week 0, week 6, week 12)

Self-reported physical activity was assessed using a modified version of the Leisure Time Exercise Questionnaire [50, 51] that has been described elsewhere [30]. Directly measured physical activity was assessed using an accelerometer (Actigraph wGT3XP-BT; Actigraph, LLC, Pensacola, Florida) and was managed with ActiLife v6.13.3 software using established wear time criteria [52] and activity count cut-points [53].

Physical outcomes (week 0, week 6, week 12)

Participants’ physical functioning was assessed via a battery of physical tests measuring body composition using a Portable HR-200 height rod and Tanita TBF-310 GS scale using bioelectrical impedance, musculoskeletal strength using the combined grip strength of the right and left hands assessed with a handheld dynamometer [54], muscular endurance using the 30-s sit to stand test [55], resting blood pressure using a blood pressure monitor (HealthSmart Digital Blood Pressure Monitor)Footnote 3, and aerobic capacity using the 6-min walk test (6MWT [54]).

Psychological outcomes (week 0, week 6, week 12)

Psychological outcomes were assessed using a self-report survey measuring self-efficacy for physical activity using a modified single-item version of the Exercise Self-Efficacy scale [56] described elsewhere [30]; physical self-perceptions using the Physical Self Description Questionnaire Short Form (PSDQ-S) subscales of strength, endurance, appearance, and body fat (3 items/subscale [57]); physical self-esteem using the PSDQ-S subscale of physical self-esteem (3 items [57]); and global self-esteem using the Rosenberg Global Self-Esteem Scale (10 items [58]). Across all surveys used to assess psychological outcomes, higher scores reflect more positive outcomes.

Qualitative interviews (week 0, week 12)

Participants’ perspectives of their physical activity, self-efficacy for physical activity, physical self-perceptions, physical self-esteem, and global self-esteem (i.e. the EXSEM variables) were obtained through semi-structured interviews at baseline (week 0) and post-intervention (week 12). For participants in the intervention group, this was commensurate with the time immediately prior to and after receiving the intervention.

For participants in the wait-list control group, this was commensurate the time immediately prior to and after their waiting period. Interviews were guided by an interview schedule containing a series of open-ended questions and probes to encourage participants to provide more detail or clarify what they were saying. Data pertaining to perceived changes in EXSEM variables are not reported herein, but will be published in forthcoming work as they are outside of the scope of the present study, which was to assess the feasibility and acceptability of the trial methods and intervention.

Sample size

No formal sample size calculation was performed based on the study objectives.

Data analysis

We conducted quantitative and qualitative analyses. Descriptive statistics consisted of frequencies, means and standard deviations (SD), and 95% confidence intervals for normally distributed data, whereas medians, interquartile ranges, and 95% confidence intervals were computed for non-normally distributed data. All descriptive statistics were estimated using IBM SPSS (Version 25 [59]). These data were used to describe the sample and report on feasibility outcomes. Content analysis of the transcribed acceptability data from the post-intervention (week 12) interview was conducted to ascertain acceptability outcomes [60].

Results

Participants

The personal and medical characteristics of participants at baseline are presented in Table 2. At week 0, participants were 32.84 (SD = 7.93) years old and had completed treatment for cancer 2.23 (SD = 1.15) years prior. On average, participants were diagnosed with cancer at 29.64 (SD = 7.73) years of age and most had received a diagnosis of breast cancer (n = 7; 44%). Others had received a diagnosis of ovarian cancer (n = 2; 13%), rhabdomyosarcoma (n = 1; 6%), biphasic peritoneal mesothelioma (n = 1; 6%), gastric cancer (n = 1; 6%), osteosarcoma (n = 1; 6%), soft tissue sarcoma (n = 1; 6%), colorectal cancer (n = 1; 6%), or Hodgkin’s lymphoma (n = 1; 6%). Half of the sample (n = 8; 50%) reported managing at least one other physical or psychological health condition (e.g. asthma, neurofibromatosis, blood clots, hypothyroidism, anxiety, depression).

Table 2 Characteristics of study participants at baseline

Participants’ baseline scores for physical activity behaviour and physical and psychological outcomes are presented in Table 3. Participants self-reported engaging in a median of 60.00 (interquartile range = 93.75) minutes of moderate-to-vigorous intensity physical activity (MVPA)/week, whereas the directly measured physical activity captured that participants were engaging in a median of 44.29 (interquartile range = 57.17) minutes of MVPA/week. On average, participants were classified as overweight (MBMI = 29.93 kg/m2, SD = 9.26). Participants’ scores on the 30-s sit to stand test were below average as compared to normative values for adults > 60 years [61] and most grip strength scores were rated as ‘poor’ (n = 7; 44%), followed by ‘good’ (n = 3; 19%), ‘fair’ (n = 3; 19%), ‘very good’ (n = 2; 6%), and ‘excellent’ (n = 1; 6%) according to established cut-offs [54]. Blood pressure was considered normal (i.e. systolic less than 120 mmHg and diastolic less than 80 mmHg) for most participants (n = 10; 63%). Aerobic capacity scores (i.e. 6MWT) were not computed due to differences in the lengths of the walking track across participants, which can artificially increase/decrease participants’ scores [62]. Finally, participants’ scores on psychological outcomes were ‘moderate’ relative to scale ranges.

Table 3 Physical activity and outcome scores for participants at baseline

Quantitative results

Feasibility

Referrals and recruitment

In total, 31 AYAs were referred/self-referred across the 12-month period (see Fig. 1). Of these, 30 were assessed for eligibility and 16 were eligible. All who were eligible consented to participate (recruitment rate = 100%). Seven participants were randomly assigned to the intervention group and nine were randomly assigned to the wait-list control group. One participant assigned to the intervention group withdrew from the trial in week 3 and was lost to follow-up (retention rate = 94%).

Fig. 1
figure 1

CONSORT flow diagram. aAfter referral, one individual could not be reached; breasons for exclusion: meeting physical activity guidelines (n = 2), age at diagnosis (n = 3), time since treatment (n = 5), treatment status (n = 4); cwithdrew due to family issues that were personally distressing.

Adherence to physical activity program (intervention group only)

During weeks 1–6, a total of 12 supervised strength sessions were provided. Participants’ adherence to these supervised strength sessions varied from 58 (7/12 sessions) to 92% (11/12 sessions) with an average adherence rate of 82% (mean = 9.83 [SD = 1.60]/12 sessions). Five of six participants adhered to ≥ 75%, or ≥ 9 of the 12 sessions. Across all participants, 13 sessions were cancelled due to travel for holidays (n = 5), illness (n = 6), and work/appointment conflicts (n = 2); however, in seven of these instances participants still completed strength sessions on their own unsupervised. During weeks 7–12, participants were instructed to participate in two unsupervised strength sessions/week to total 12 unsupervised strength sessions. Adherence to the unsupervised strength sessions ranged from 50 (6/12 sessions) to 92% (11/12 sessions) with an average adherence rate of 69% (mean = 8.33 [SD = 1.97]/12 sessions). Three of six participants adhered to ≥ 75%, or ≥ 9 of the 12 sessions. Most sessions during weeks 7–12 were missed due to being too busy, tired, or ‘lazy’ (n = 21); one session was missed due to illness. Throughout weeks 1–12, participants were instructed to participate in two unsupervised aerobic sessions/week to total 24 unsupervised aerobic sessions. Adherence to the unsupervised aerobic sessions ranged from 54 (13/24 sessions) to 88% (21/24 sessions) with an average adherence rate of 76% (mean = 18.17 [SD = 2.93]/24 sessions). Four of six participants adhered to ≥ 75%, or ≥ 18 of the 24 sessions. The main reasons unsupervised aerobic sessions were missed were: being too busy or tired (n = 23); illness (n = 7); work conflicts (n = 2); holidays (n = 2), and; an unrelated injury (n = 1).

Missing data

There were no missing data on self-reported physical activity behaviour and psychological outcomes for study completers (n = 15). For physical tests, participants completed all measures of body composition, musculoskeletal strength, muscular endurance, and resting blood pressure. However, there were missing data for aerobic capacity and directly measured physical activity behaviour (as assessed using accelerometers). With regard to the former, there were 21 instances of missing aerobic capacity data (out of a possible 45 data points) as six participants could not complete the test at all three time-points due to high blood pressure (a skipping criteria for this assessment was stipulated by the study protocol; n = 18) and three participants elected to not complete the test for aerobic capacity at a single time-point due to weather (n = 2)Footnote 4 or feeling unwell (n = 1). With regard to the latter, there were 13 instances of missing accelerometer data (out of a possible 45 data points) due to: insufficient wear time (i.e. < 3 days of valid wear time; n = 8); accelerometer dysfunction (n = 1), and; participant error (e.g. wearing the accelerometer incorrectly; n = 4). Combined, there were < 10% missing quantitative data across all three time-points for the 15 participants who completed the study. All study completers (n = 15) participated in both qualitative interviews.

Qualitative results

Acceptability

During the interviews, no issues surrounding acceptability with the trial methods were raised. Participants said they accepted to be randomized and were highly satisfied with the opportunity to receive a 12-week physical activity program (either immediately or after a waiting period). Participants did not identify any issues related to the assessments or trial procedures. In other words, the number, timing, and duration of assessments and trial-related procedures were deemed acceptable.

Participants randomized to the intervention group held positive regard for the individualized, pragmatic, and progressive nature of the intervention, which was highlighted by [P4] when she said: ‘I liked that we could focus so much on what I needed. Like what I really needed help with was the core stuff because of how damaged it was through my treatment and recovery’, and [P1] when she stated: ‘I thought it was good for adaptation and modification. I also liked the fact it was at our own leisure, and I liked the flexibility of it’. Moreover, participants valued the usefulness of the skills they learned and positively evaluated the performance and skills of the first author who delivered the intervention.

However, participants expressed challenges integrating physical activity into their lives because they had difficulty planning for and overcoming barriers, such as having busy schedules and travel requirements. Further, participants expressed difficulty transitioning from supervised (weeks 1–6) to unsupervised (weeks 7–12) strength training sessions and suggested a more gradual stepped down approach: ‘…instead of going cold turkey at the 6 weeks, if we had gone to one time a week, tapering off to me being on my own. At some point I know I have to be responsible, so I feel it is a 2-way street as well, but if that was built in, it couldn’t hurt’ [P14]. As well, participants commented that more instruction and support for the unsupervised aerobic training (weeks 1–12) would have been helpful: ‘I also felt if we would have had, maybe, I don’t know, like a sheet that would give us ideas of what to do for the aerobic sessions. I know, at least for me, I get bored with just running or walking’ [P7].

Discussion

The purpose of this two-arm, mixed-methods pilot RCT was to lay the foundation for a future definitive RCT examining if/how and under what circumstances physical activity impacts physical and psychological outcomes in AYA cancer survivors. Though recruitment, retention, and missing data rates were better than targets set a priori and superior to other trials testing distance-based physical activity interventions (e.g. telephone counselling, Facebook [46, 47]), the number of AYA cancer survivors referred/self-referred and participants’ adherence to the intervention were below targets. Findings from this pilot RCT highlight specific aspects of the trial methods and intervention that were feasible as well as those aspects that were not feasible. Modifications to trial methods and intervention components are warranted and require additional piloting before a sufficiently powered definitive RCT can be considered.

The lower than anticipated referrals/self-referrals highlights the difficulty researchers are likely to encounter when seeking to identify and recruit AYA cancer survivors to participate in their physical activity research. Lower referrals/self-referrals may be due, in part, to the rarity of cancer in this age cohort [63, 64] and population-specific barriers to participating in trials (e.g. geographic mobility, small numbers [65]). Moving forward, researchers interested in this line of work may wish to collaborate and conduct multi-site trials to increase sample sizes, ultimately ensuring adequately powered studies. Further, using recruitment strategies beyond those used herein may increase the number of AYA cancer survivors referred or who self-refer and ensure greater diversity (e.g. younger AYA cancer survivors, different types of cancers). For example, researchers could consider mailing/emailing trial brochures using tumour registries, attending hospital rounds and recruiting in-person, and/or attending cancer-related events/groups [66]. Partnering with organizations that typically include AYA cancer survivors in their network and using Internet and social networking are other low-/no-cost options [66].

The higher than anticipated recruitment and retention rates observed are promising for those seeking to deliver physical activity interventions to AYA cancer survivors. Findings re-affirm reports that some AYA cancer survivors are eager to participate in lifestyle interventions [43, 67] and want access to health promoting services during this time (i.e. < 5 years post-treatment [68])—widely considered a ‘teachable moment’ in the general cancer literature [69, 70]. However, the rates reported are associated with significant limitations (described in greater detail in the ‘Limitations and considerations’ section) and do little to extend knowledge regarding those AYA cancer survivors who may lack motivation to participate in physical activity-based research.

Missing data are inevitable in trials, yet there were only two measures on which any missing data were documented in this pilot RCT: the objective assessment of aerobic capacity and directly measured physical activity behaviour using accelerometers (see next paragraph for a discussion on this). Nonetheless, this shows the feasibility and acceptability of assessing AYA cancer survivors at multiple times (i.e. baseline, mid-intervention, post-interventions) using a combination of quantitative (directly measured physical activity, physical tests, surveys) and qualitative tools (interview). Moreover, this was found despite the assessments taking > 1.5 h to complete. This may be because the survey and interview included questions previously deemed to be clear, appropriate, and relevant to AYA cancer survivors [71].

In terms of lessons learned with regard to assessment selection, there were missing data on the objective assessment of aerobic capacity. Specifically, the 6MWT (without appropriate monitoring and the supervision of a certified exercise physiologist) was contraindicated due to high blood pressure for six participants during at least one of their assessments, and there were three instances wherein participants chose not to complete an assessment. Further, the distance of the walking track could not be standardized at any time-points across participants due to the location of assessments (e.g. home, apartment hallway). Discrepancies in length can artificially increase/decrease scores on this assessment [62]; thus, 6MWT data for those who could complete the assessment were not reported herein. In the future, researchers and practitioners may wish to omit this assessment or conduct it within a research/healthcare centre to ensure appropriate monitoring, supervision, and standardization. Second, there were missing accelerometer data despite employing recommended strategies to enhance accelerometer compliance (i.e. modelling proper accelerometer use, providing verbal and written instructions, sending reminder messages [72]) and most participants self-reporting in their logbook that they had worn the accelerometer for the required amount of time. This suggests the missing data may not be related to participants’ unwillingness to complete this assessment, but may be related to the process by which missing data points are identified. As there is considerable variability across protocols for determining non-wear (i.e. missing data) and wear time, population-specific protocols are suggested [73]. No protocols have been developed with/for AYA cancer survivors, leaving questions regarding the frequency, pattern, and duration of non-wear and wear times in this population unanswered. Those wishing to include accelerometers in their studies with AYA cancer survivors might consider protocols least affected by wear time and monitor inactivity (e.g. 120 min [74]).

Though participants appreciated the pragmatic nature of the physical activity intervention, adherence was lower than expected, ranging from 50 to 92%. Data from participants’ interviews provided insight into reasons underlying these findings and suggests modifications to the intervention are necessary. This sample had a hard time scheduling and overcoming barriers to engage in physical activity. To help older adult cancer survivors successfully change their behaviour, to achieve desired physical and psychological benefits researchers and practitioners have taught them about the importance of planning physical activity sessions (e.g. scheduling) and have helped them identify barriers to physical activity (e.g. travel) and strategies to overcome them (i.e. problem solving and action planning; e.g. packing a resistance band). Such strategies/skills are known as behaviour change techniques (BCTs [75]). BCTs are the ‘observable, replicable, and irreducible component’ of interventions designed to increase physical activity behaviour [75]. Trials including BCTs have reported greater adherence and behaviour change compared to those that do not [76,77,78]. Given the critical role BCTs can play in promoting physical activity [79], examining the feasibility and acceptability of integrating BCTs into physical activity interventions for AYA cancer survivors is warranted.

Finally, findings underscore that more pilot work is necessary to optimize the 12-week physical activity program tested. Though the program was individualized based on physical assessment data and designed to maximize change from a physiological perspective, the intervention itself was not individualized according to psychological preferences. Given the varied physical activity preferences of cancer survivors [80] and increasing calls for personalized care in AYA oncology [65], researchers should explore preference-based physical activity trials in this population (e.g. home- or centre-based; yoga or strength training). Similarly, testing different approaches for transitioning from supervised to unsupervised physical activity, wherein survivors receive support that is matched to their needs/wants [81], might be worthwhile. Among older adult cancer survivor, triaged models of physical activity delivery have been shown to be a beneficial and cost-effective means to identify individuals requiring more/less support and offering appropriate care [82,83,84]. Considering current resource constraints (e.g. personnel, infrastructure) and limited funding available, such approaches may also lower costs needed to translate successful models into care. Moving forward, refining, piloting and testing different study designs (e.g. preference-based trials) and triaged approaches with AYA cancer survivors could answer important research questions, ultimately ensuring this population receives individualized interventions and care. If these and other changes are made, cost description analyses for participants (i.e. time, costs) and researchers (e.g. personnel time and costs, materials/equipment) will be necessary to inform future trials and scalability initiatives.

Limitations and considerations

Although this pilot RCT provides useful feasibility and acceptability data for researchers wishing to explore physical activity with AYA cancer survivors, there are some major and minor limitations that should be considered. With regard to the major limitations, the recruitment strategies used (i.e. healthcare provider referral and self-referral) did not provide data on the number or characteristics of AYA cancer survivors who were eligible but not interested, and therefore did not consent to be contacted or self-refer. Thus, the recruitment rate presented herein likely reflects only those AYA cancer survivors who intended to participate, and as a result may be higher than if alternative recruitment strategies and/or tracking systems were used. Relatedly, it is possible that the retention and missing data estimates would be lower and higher, respectively, if less motivated AYA cancer survivors were recruited. Despite our efforts to identify inactive or insufficiently active AYA cancer survivors (to limit ceiling effects in a definitive RCT and to explore whether inactive/insufficiently active AYA cancer survivors could be recruited), baseline assessments showed some participants were engaging in physical activity, with one participant meeting current physical activity recommendations. Revisions to this pilot RCTs protocol should incorporate strategies to collect data on eligible but not interested AYA cancer survivors and test targeted strategies to recruit less motivated AYA cancer survivors. At the same time, concerted efforts to recruit a more heterogeneous sample comprised of AYA cancer survivors with different types of cancer, who are younger (i.e. adolescents at time of diagnosis and study), and self-identify as male will be required in advance of a future definitive RCT to ensure generalizability.

With regard to minor limitations, the first author performed the intervention and all assessments (including the acceptability interviews). This may have influenced participants’ responses, such that they responded more positively than they actually wanted to. Moreover, the acceptability interviews were conducted post-intervention (week 12) only; wait-list control group participants were therefore not asked about their experiences with the physical activity intervention since they had not yet started the intervention. Including perspectives of wait-list control group participants might have resulted in additional insights. Fidelity, though tracked by the first author, was not objectively assessed. This has implications and calls to question whether the findings are due to the trial methods/intervention content or other factors. As well, the feasibility and acceptability of including follow-up assessments remains unknown. To better prepare for a fundable definitive RCT and enable examination of physical activity behaviour change maintenance, piloting follow-up assessments will be necessary. Finally, the results presented herein are only applicable to the trial methods and intervention piloted and could be different based on changes to recruitment strategies, assessments (e.g. measurement tools, timing), and the intervention (e.g. frequency, intensity, delivery style, context). Modifications to each may result in additional challenges/barriers to feasibility and acceptability.

Conclusions

In conclusion, the methods and intervention comprising this two-arm, mixed-methods pilot RCT require modifications and further piloting before being deemed feasible and acceptable. Findings underscore the necessity of conducting pilot RCTs to identify problems in advance of time- and resource-consuming definitive RCTs. Further, results suggest fostering collaborations, working across sites, and using multiple and varied sources of recruitment are necessary to increase the number of AYA cancer survivors referred, approached, and enrolled. Researchers should also ensure study assessments are appropriate and relevant for AYA cancer survivors, and should carefully consider assessments of aerobic capacity and protocols for directly measured physical activity behaviour to reduce missing data. Finally, adding behavioural support through the inclusion of BCTs and testing different models incorporating stepped-down and/or triaged approaches may help some AYA cancer survivors overcome barriers to physical activity and enhance adherence and acceptability. Should these, and other changes, be made, cost description analysis are warranted. This study provides critically useful data that can be used to inform future pilot trials seeking to establish feasibility and acceptability, with the ultimate goal of demonstrating causation and optimizing physical activity interventions to enhance physical and psychological health for AYA cancer survivors – a population that has been underrepresented in the literature.

Availability of data and materials

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

Notes

  1. Determined based on potential participants’ responses to a series of physical activity readiness screening questions. If a participant’s responses to screening questions indicated cause for concern, they were required to obtain medical clearance from their healthcare provider using the Physical Activity Readiness Medical Examination Form (PARmed-X) prior to participating in the study.

  2. The first author is a certified personal trainer who had 6 years experience conducting physical activity interventions with cancer survivors at the time of the study.

  3. When systolic blood pressure was ≥ 160 mmHg and/or diastolic blood pressure ≥ 90 mmHg, medical clearance from participants healthcare provider was required using the PARmed-X and the test of aerobic capacity (i.e. 6MWT) was skipped to reduce the risk of myocardial infarction [54].

  4. Due to space constraints in their home, two participants completed the aerobic assessment outdoors.

Abbreviations

6MWT:

6-min walk test

AYA:

Adolescent and young adult

BCTs:

Behaviour change techniques

BMI:

Body mass index

EXSEM:

Exercise and self-esteem model

HRR:

Heart rate reserve

MVPA:

Moderate-to-vigorous physical activity

PARmed-X:

Physical Activity Readiness Medical Examination Form

PSDQ-S:

Physical Self Description Questionnaire Short Form

RCT:

Randomized controlled trial

RM:

Repetition maximum

SD:

Standard deviation

References

  1. Bleyer A, Ferrari A, Whelan J, Barr RD. Global assessment of cancer incidence and survival in adolescents and young adults. Pediatr Blood Cancer. 2017;64(9). https://doi.org/10.1002/pbc.26497.

    Article  Google Scholar 

  2. Hallquist VP. Late Effects: Focus on adolescent and young adult cancer survivors. J Adv Pract Oncol. 2016;7(1):15–6.

    Google Scholar 

  3. Quinn GP, Goncalves V, Sehovic I, Bowman ML, Reed DR. Quality of life in adolescent and young adult cancer patients: a systematic review of the literature. Patient Relat Outcome Meas. 2015;6:19–51.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Tai E, Buchanan N, Townsend J, Fairley T, Moore A, Richardson LC. Health status of adolescent and young adult cancer survivors. Cancer. 2012;118(19):4884–91.

    Article  PubMed  Google Scholar 

  5. Sanford SD, Zhao F, Salsman JM, Chang VT, Wagner LI, Fisch MJ. Symptom burden among young adults with breast or colorectal cancer. Cancer. 2014;120(15):2255–63.

    Article  PubMed  Google Scholar 

  6. Devlin SM, Murphy JD, Yeung HN. A retrospective analysis of pain burden in hospitalized young adult cancer patients compared with their older adult counterpart. J Palliat Med. 2018;22(3):307–9.

    Article  PubMed  Google Scholar 

  7. Lang MJ, Giese-Davis J, Patton SB, Campbell DJT. Does age matter? Comparing post-treatment psychosocial outcomes in young adult and older adult cancer survivors with their cancer-free peers. Psychooncology. 2018;27(5):1404–11.

    Article  PubMed  Google Scholar 

  8. Epelman CL. The adolescent and young adult with cancer: state of the art -- psychosocial aspects. Curr Oncol Rep. 2013;15(4):325–31.

    Article  PubMed  Google Scholar 

  9. McGoldrick D, Gordon P, Whiteson M, Adams H, Rogers P, Sutcliffe S. Awareness and advocacy for adolescents and young adults with cancer. Cancer. 2011;117(10):2311–5.

    Article  PubMed  Google Scholar 

  10. Adolescent and Young Adult Oncology Progress Review Group. Closing the gap: research and care imperatives for adolescents and young adults with cancer. U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute, the LIVESTRONG Young Adult Alliance. 2006.

  11. Cormie P, Zopf EM, Zhang X, Schmitz KH. The impact of exercise on cancer mortality, recurrence, and treatment-related adverse effects. Epidemiol Rev. 2017;39(1):71–92.

    Article  PubMed  Google Scholar 

  12. Segal R, Zwaal C, Green E, Tomasone JR, Loblaw A, Petrella T, et al. Exercise for people with cancer: a systematic review. Curr Oncol. 2017;24(4):e290–315.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Stout NL, Baima J, Swisher AK, Winters-Stone KM, Welsh J. A systematic review of exercise systematic reviews in the cancer literature (2005-2017). PM R. 2017;9(9):S347–84.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Gundle KR, Punt SE, Mattioli-Lewis T, Conrad EU. Can a made-for-consumer activity monitor assess physical activity in adolescents and young adults after lower extremity limb salvage for osseous tumors? J Pediatr Ortho. 2016;37(3):e192–6.

    Article  Google Scholar 

  15. Erickson JM, Adelstein KE, Letzkus LC. A feasibility study to measure physical activity, fatigue, sleep-wake disturbances, and depression in young adults during chemotherapy. J Adolesc Young Adult Oncol. 2014;3(1):37–41.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Brunet J, Wurz A, Shallwani SM. A scoping review of studies exploring physical activity among adolescents and young adults diagnosed with cancer. Psychooncology. 2018;27(8):1875–88.

    Article  PubMed  Google Scholar 

  17. Brunet J, Love C, Ramphal R, Sabiston CM. Stress and physical activity in young adults treated for cancer: the moderating role of social support. Support Care Cancer. 2014;22(3):689–95.

    Article  PubMed  Google Scholar 

  18. Love C, Sabiston CM. Exploring the links between physical activity and posttraumatic growth in young adult cancer survivors. Psycho Oncol. 2011;20(3):278–86.

    Article  Google Scholar 

  19. Valle CG, Tate DF, Mayer DK, Allicock M, Cai J. Exploring mediators of physical activity in young adult cancer survivors: evidence from a randomized trial of a Facebook-based physical activity intervention. J Adolesc Young Adult Oncol. 2015;4(1):26–33.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Sonstroem RJ, Morgan WP. Exercise and self-esteem: rationale and model. Med Sci Sports Exerc. 1989;21(3):329–37.

    Article  CAS  PubMed  Google Scholar 

  21. Moore JB, Mitchell NG, Beets MW, Bartholomew JB. Physical self-esteem in older adults: a test of the indirect effect of physical activity. Sport Exerc Perform Psychol. 2012;1(4):231–41.

    Article  Google Scholar 

  22. Dodd RK, Vetter RE. College females’ self-perceptions of their overall self-worth. Am J Health Stud. 2015;30(3):110–8.

    Google Scholar 

  23. Musanti R. A study of exercise modality and physical self-esteem in breast cancer survivors. Med Sci Sports Exerc. 2012;44(2):352–61.

    Article  PubMed  Google Scholar 

  24. Awick EA, Phillips SM, Lloyd GR, McAuley E. Physical activity, self-efficacy and self-esteem in breast cancer survivors: a panel model. Psychooncology. 2017;26(10):1625–31.

    Article  PubMed  Google Scholar 

  25. Baldwin MK, Courneya KS. Exercise and self-esteem in breast cancer survivors: an application of the exercise and self-esteem model. J Sport Exerc Psychol. 1997;19:347–58.

    Article  Google Scholar 

  26. Belanger LJ, Plotnikoff RC, Clark A, Courneya KS. Physical activity and health-related quality of life in young adult cancer survivors: a Canadian provincial survey. J Cancer Surviv. 2011;5(1):44–53.

    Article  PubMed  Google Scholar 

  27. Belanger LJ, Plotnikoff RC, Clark A, Courneya KS. Prevalence, correlates, and psychosocial outcomes of sport participation in young adult cancer survivors. Psychol Sport Exerc. 2013;14:298–304.

    Article  Google Scholar 

  28. Gill E, Goldenberg M, Starnes H, Phelan S. Outdoor adventure therapy to increase physical activity in young adult cancer survivors. J Psychosoc Oncol. 2016;34(3):184–99.

    Article  PubMed  Google Scholar 

  29. Adamsen L, Andersen C, Midtgaard J, Moller T, Quist M, Rorth M. Struggling with cancer and treatment: young athletes recapture body control and identity through exercise: qualitative findings from a supervised group exercise program in cancer patients of mixed gender undergoing chemotherapy. Scand J Med Sci Sports. 2009;19(1):55–66.

    Article  CAS  PubMed  Google Scholar 

  30. Wurz A, Brunet, J. Describing and exploring self‐esteem, physical self‐perceptions, physical activity and self‐efficacy in adolescent and young adult cancer survivors. Eur J Cancer Care. 2009;00:e13179. https://doi.org/10.11111/ecc/13179.

  31. Campbell M, Fitzpatrick R, Haines A, Kinmonth AL, Sandercock P, Spiegelhalter D, et al. Framework for design and evaluation of complex interventions to improve health. BMJ. 2000;321(7262):694–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Thabane L, Ma J, Chu R, Cheng J, Ismaila A, Rios LP, et al. A tutorial on pilot studies: the what, why and how. BMC Med Res Methodol. 2010;10:1.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Eldridge SM, Chan CL, Campbell MJ, Bond CM, Hopewell S, Thabane L, et al. CONSORT 2010 statement: extension to randomised pilot and feasibility trials. Pilot Feasibil Stud. 2016;2:64.

    Article  Google Scholar 

  34. Kilka R, Tamburini A, Galanti G, Mascherini G, Stefani L. The role of exercise in pediatric and adolescent cancers: a review of assessments and suggestions for clinical implementation. J Funct Morph Kines. 2018;3(7):1–19.

    Google Scholar 

  35. Rustler V, Hagerty M, Daeggelmann J, Marjerrison S, Bloch W, Baumann FT. Exercise interventions for patients with pediatric cancer during inpatient acute care: a systematic review of literature. Pediatr Blood Cancer. 2017;64:11.

    Article  Google Scholar 

  36. Segal R, Zwaal C, Green E, Tomasone JR, Loblaw A, Petrella T, et al. Exercise for people with cancer: a clinical practice guideline. Curr Oncol. 2017;24(1):40–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galvao DA, Pinto BM, et al. American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc. 2010;42(7):1409–26.

    Article  PubMed  Google Scholar 

  38. McCorkle R, Ercolano E, Lazenby M, Schulman-Green D, Schilling LS, Lorig K, et al. Self-management: enabling and empowering patients living with cancer as a chronic illness. CA Cancer J Clin. 2011;61(1):50–62.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Howell D, Harth T, Brown J, Bennett C, Boyko S. Self-management education interventions for patients with cancer: a systematic review. Supp Care Cancer. 2017;25(4):1323–55.

    Article  Google Scholar 

  40. Ferrer RA, Huedo-Medina TB, Johnson BT, Ryan S, Pescatello LS. Exercise interventions for cancer survivors: a meta-analysis of quality of life outcomes. Ann Behav Med. 2011;41(1):32–471.

    Article  PubMed  Google Scholar 

  41. Belanger LJ, Plotnikoff RC, Clark A, Courneya KS. A survey of physical activity programming and counseling preferences in young-adult cancer survivors. Cancer Nurs. 2012;35(1):48–54.

    Article  PubMed  Google Scholar 

  42. Murnane A, Gough K, Thompson K, Holland L, Conyers R. Adolescents and young adult cancer survivors: exercise habits, quality of life and physical activity preferences. Support Care Cancer. 2015;23(2):501–10.

    Article  CAS  PubMed  Google Scholar 

  43. Pugh G, Hough RE, Gravestock HL, Jackson SE, Fisher A. The health behavior information needs and preferences of teenage and young adult cancer survivors. J Adolesc Young Adult Oncol. 2017;6(2):318–26.

    Article  PubMed  Google Scholar 

  44. Tsangaris E, Johnson J, Taylor R, Fern L, Bryant-Lukosius D, Barr R, et al. Identifying the supportive care needs of adolescent and young adult survivors of cancer: a qualitative analysis and systematic literature review. Support Care Cancer. 2014;22(4):947–59.

    Article  PubMed  Google Scholar 

  45. Schulz KF, Grimes DA. Sample size slippages in randomised trials: exclusions and the lost and wayward. Lancet. 2002;359(9308):781–5.

    Article  PubMed  Google Scholar 

  46. Valle CG, Tate DF, Mayer DK, Allicock M, Cai J. A randomized trial of a Facebook-based physical activity intervention for young adult cancer survivors. J Canc Suvivor. 2013;7(3):355–68.

    Article  Google Scholar 

  47. Rabin C, Pinto B, Fava J. Randomized trial of a physical activity and meditation intervention for young adult cancer survivors. J Adolesc Young Adult Oncol. 2016;5(1):41–7.

    Article  PubMed  Google Scholar 

  48. Ormel HL, van der Schoot GGF, Sluiter WJ, Jalving M, Gietema JA, Walenkamp AME. Predictors of adherence to exercise interventions during and after cancer treatment: a systematic review. Psychooncology. 2018;27(3):713–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Kopp LM, Gastelum Z, Guerrero CH, Howe CL, Hingorani P, Hingle M. Lifestyle behavior interventions delivered using technology in childhood, adolescent, and young adult cancer survivors: a systematic review. Pediatr Blood Cancer. 2017;64(1):13–7.

    Article  PubMed  Google Scholar 

  50. Godin G, Shephard RJ, Godin G, Shephard RJ. Godin Leisure-Time Exercise Questionnaire. Med Sci Sport Exerc. 1997;29:S36–8.

    Google Scholar 

  51. Godin G, Shephard RJ. A simple method to assess exercise behavior in the community. Can J Appl Sport Sci. 1985;10(3):141–6.

    CAS  PubMed  Google Scholar 

  52. Choi L, Liu Z, Matthews CE, Buchowski MS. Validation of accelerometer wear and nonwear time classification algorithm. Med Sci Sports Exerc. 2011;43(2):357–64.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Freedson PS, Melanson E, Sirard J. Calibration of the computer science and applications, Inc. accelerometer. Med Sci Sports Exerc. 1998;30(5):777–81.

    Article  CAS  PubMed  Google Scholar 

  54. Canadian Society for Exercise Physiology. Canadian Society for Exercise Physiology - Physical Activity Training for Health (CSEP-PATH). Ottawa: Canadian Society for Exercise Physiology; 2013.

    Google Scholar 

  55. Rikli R, Jones J. Senior fitness test manual. Champaign: Human Kinetics; 2001.

    Google Scholar 

  56. McAuley E. Self-efficacy and the maintenance of exercise participation in older adults. J Behav Med. 1993;16(1):103–13.

    Article  CAS  PubMed  Google Scholar 

  57. Marsh HW, Martin AJ, Jackson S. Introducing a short version of the physical self description questionnaire: new strategies, short-form evaluative criteria, and applications of factor analyses. J Sport Exerc Psychol. 2010;32(4):438–82.

    Article  PubMed  Google Scholar 

  58. Rosenberg M. Society and adolescent self-image. Princeton: Princeton University Press; 1965.

    Book  Google Scholar 

  59. IBM Corp. IBM SPSS Statistics for Macintosh. Armonk: IBM Corp. Released; 2017.

    Google Scholar 

  60. Krippendorff K. Content analysis: an introduction to its methodology. Thousand Oaks: SAGE; 2013.

    Google Scholar 

  61. Jones CJ, Rikli RE, Beam WC. A 30-s chair-stand test as a measure of lower body strength in community-residing older adults. Res Q Exerc Sport. 1999;70(2):113–9.

    Article  CAS  PubMed  Google Scholar 

  62. Scivoletto G, Tamburella F, Laurenza L, Foti C, Ditunno JF, Molinari M. Validity and reliability of the 10-m walk test and the 6-min walk test in spinal cord injury patients. Spinal Cord. 2011;49(6):736–40.

    Article  CAS  PubMed  Google Scholar 

  63. American Cancer Society. Cancer Facts & Figures 2015. Atlanta; 2015.

  64. Canadian Cancer Society’s Advisory Committee on Cancer Statistics. Canadian Cancer Statistics 2015. Toronto; 2015.

  65. Barr RD, Ries R, Ferrari A, Whelan J, Bleyer A. Adolescent and young adult oncology: historical and global perspectives. In: Bleyer A, Barr R, Ries L, Whelan J, Ferrari A, editors. Cancer in adolescents and young adults. 2nd ed. Cham: Springer International Publishing AG (Springer Nature); 2017. p. 1–7.

    Google Scholar 

  66. Rabin C, Horowitz S, Marcus B. Recruiting young adult cancer survivors for behavioral research. J Clin Psychol Med Settings. 2013;20(1):33–6.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Pugh G, Hough R, Gravestock H, Haddrell JB, Beeken RJ, Fisher A. The lifestyle information and intervention preferences of teenage and young adult cancer survivors: a qualitative study. Cancer Nurs. 2018;41(5):389–98.

    Article  PubMed  Google Scholar 

  68. Wong JN, McAuley E, Trinh L. Physical activity programming and counseling preferences among cancer survivors: a systematic review. Int J Behav Nutr Phys Act. 2018;15(1):48.

    Article  PubMed  PubMed Central  Google Scholar 

  69. Frazelle ML, Friend PJ. Optimizing the teachable moment for health promotion for cancer survivors and their families. J Adv Pract Oncol. 2016;7(4):422–33.

    PubMed  PubMed Central  Google Scholar 

  70. Bellizzi KM, Smith A, Schmidt S, Keegan TH, Zebrack B, Lynch CF, et al. Positive and negative psychosocial impact of being diagnosed with cancer as an adolescent or young adult. Cancer. 2012;118(20):5155–62.

    Article  PubMed  Google Scholar 

  71. Wurz A, Brunet J. Evaluating questionnaires used to assess self-reported physical activity and psychosocial outcomes among survivors of adolescent and young adult cancer: a cognitive interview study. J Adolesc Young Adult Oncol. 2017;6(3):482–8.

    Article  PubMed  Google Scholar 

  72. Trost SG, McIver KL, Pate RR. Conducting accelerometer-based activity assessments in field-based research. Med Sci Sports Exerc. 2005;37(11):S531–43.

    Article  PubMed  Google Scholar 

  73. Chudyk AM, McAllister MM, Cheung HK, McKay HA, Ashe MC. Are we missing the sitting? Agreement between accelerometer non-wear time validation methods used with older adults’ data. Cogent Med. 2017;4:1313505.

    Article  PubMed  PubMed Central  Google Scholar 

  74. King WC, Li J, Leishear K, Mitchell JE, Belle SH. Determining activity monitor wear time: an influential decision rule. J Phys Act Health. 2011;8(4):566–80.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Michie S, Richardson M, Johnston M, Abraham C, Francis J, Hardeman W, et al. The behavior change technique taxonomy (v1) of 93 hierarchically clustered techniques: building an international consensus for the reporting of behavior change interventions. Ann Behav Med. 2013;46(1):81–95. https://doi.org/10.1007/s12160-013-9486-6.

    Article  PubMed  Google Scholar 

  76. Hallward L, Patel N, Duncan LR. Behaviour change techniques in physical activity interventions for men with prostate cancer: a systematic review. J Health Psychol. 2018;1359105318756501.

  77. Stacey FG, James EL, Chapman K, Courneya KS, Lubans DR. A systematic review and meta-analysis of social cognitive theory-based physical activity and/or nutrition behavior change interventions for cancer survivors. J Cancer Surviv. 2015;9(2):305–38.

    Article  PubMed  Google Scholar 

  78. Bluethmann SM, Vernon SW, Gabriel KP, Murphy CC, Bartholomew LK. Taking the next step: a systematic review and meta-analysis of physical activity and behavior change interventions in recent post-treatment breast cancer survivors. Breast Cancer Res Treat. 2015;149(2):331–42.

    Article  PubMed  PubMed Central  Google Scholar 

  79. Finne E, Glausch M, Exner AK, Sauzet O, Stolzel F, Seidel N. Behavior change techniques for increasing physical activity in cancer survivors: a systematic review and meta-analysis of randomized controlled trials. Cancer Manag Res. 2018;10:5125–43. https://doi.org/10.2147/CMAR.S170064.

    Article  PubMed  PubMed Central  Google Scholar 

  80. Szymlek-Gay EA, Richards R, Egan R. Physical activity among cancer survivors: a literature review. N Z Med J. 2011;124(1337):77–89.

    PubMed  Google Scholar 

  81. Santa Mina D, Sabiston CM, Au D, Fong AJ, Capozzi LC, Langelier D, et al. Connecting people with cancer to physical activity and exercise programs: a pathway to create accessibility and engagement. Curr Oncol. 2018;25(2):149–62.

    Article  PubMed  Google Scholar 

  82. Dalzell MA, Smirnow N, Sateren W, Sintharaphone A, Ibrahim M, Mastroianni L, et al. Rehabilitation and exercise oncology program: translating research into a model of care. Curr Oncol. 2017;24(3):e191–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Egan MY, McEwen S, Sikora L, Chasen M, Fitch M, Eldred S. Rehabilitation following cancer treatment. Disabil Rehabil. 2013;35(26):2245–58.

    Article  PubMed  Google Scholar 

  84. Mewes JC, Steuten LM, Ijzerman MJ, van Harten WH. Effectiveness of multidimensional cancer survivor rehabilitation and cost-effectiveness of cancer rehabilitation in general: a systematic review. Oncologist. 2012;17(12):1581–93.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The authors would like to thank the individuals who participated in this study, Lululemon Athletica, Polar Electro Oy, Bushtukah, and Reform Health & Fitness for their generous donations, and the Ottawa Regional Cancer Foundation for providing space for assessments and physical activity sessions. Data were collected and this article was prepared while the first author was supported by a Vanier Canada Graduate scholarship.

Funding

The authors declare that no funding was received for this project.

Author information

Authors and Affiliations

Authors

Contributions

AW secured donations, designed and delivered the intervention, collected and analysed all data, drafted and revised the manuscript, and is the primary author of the manuscript. JB oversaw all aspects of the study design and delivery and contributed to drafting the final manuscript. Both authors read and approved the final manuscript.

Corresponding author

Correspondence to Jennifer Brunet.

Ethics declarations

Ethics approval and consent to participate

Informed consent was obtained from all individual participants included in the study.

Ottawa Health Science Network Research Ethics Board Protocol Number: 20160612-01H

University of Ottawa Research Ethics Board Protocol Number: A03-17-06

Children’s Hospital of Eastern Ontario Research Ethics Board Protocol Number: 16/110X

Royal Ottawa Mental Health Centre Research Ethics Board Protocol Number: 2017013

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Additional file 1.

CONSORT 2010 checklist of information to include when reporting a pilot or feasibility trial.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wurz, A., Brunet, J. Exploring the feasibility and acceptability of a mixed-methods pilot randomized controlled trial testing a 12-week physical activity intervention with adolescent and young adult cancer survivors. Pilot Feasibility Stud 5, 154 (2019). https://doi.org/10.1186/s40814-019-0530-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s40814-019-0530-6

Keywords