Multimorbidity, polypharmacy, and older age predispose seniors to adverse drug events (ADE). Seniors with an ADE experience greater morbidity, mortality, and health care utilization compared to their younger c...
Authors: Joanne Man-Wai Ho, Jennifer Tung, Janine Maitland, Derelie Mangin, Lehana Thabane, J. Michael Pavlin, Jeffrey Alfonsi, Anne Holbrook, Sharon Straus and Sophiya Benjamin
Maternal mental health conditions are prevalent across the world. For women, the perinatal period is associated with increased rates of depression and anxiety. At the same time, there is widespread documentati...
Authors: Caprice Knapp, Simone Honikman, Michael Wirsching, Gidah Husni-Pascha and Eva Hänselmann
Acute respiratory failure (ARF) is a common and life-threatening medical emergency. Standard prehospital management involves controlled oxygen therapy and disease-specific ancillary treatments. Continuous posi...
Authors: Gordon W. Fuller, Steve Goodacre, Samuel Keating, Gavin Perkins, Matthew Ward, Andy Rosser, Imogen Gunson, Joshua Miller, Mike Bradburn, Praveen Thokala, Tim Harris, Andrew Carson, Maggie Marsh and Cindy Cooper
One third of women experience intimate partner violence (IPV) in their lifetime. Orthopaedic health care professionals are in a good position to identify women experiencing escalating physical violence and act...
The harmful use of alcohol is a causal factor in more than 200 disease and injury conditions and leads to over 3 million deaths every year worldwide. Relatively few problem alcohol users access treatment due t...
Authors: Fiona L. Hamilton, Jo Hornby, Jessica Sheringham, Stuart Linke, Charlotte Ashton, Kevin Moore, Fiona Stevenson and Elizabeth Murray
State health agencies (SHA) and local health agencies (LHA) face several challenges with the dissemination of local health data using Web-Based Data Query Systems (WDQS). To help guide future research, this st...
Authors: Manik Ahuja, Robert Aseltine, Nicholas Warren, Susan Reisine, Pam Holtzclaw Williams and Andy Cislo
We used various methods for identifying and prioritizing patient-centered outcomes (PCOs) for comparative effectiveness research (CER).
Authors: Evan Mayo-Wilson, Asieh Golozar, Terrie Cowley, Nicole Fusco, Gillian Gresham, Jennifer Haythornthwaite, Elizabeth Tolbert, Jennifer L. Payne, Lori Rosman, Susan Hutfless, Joseph K. Canner and Kay Dickersin
Fatigue is rated as the most distressing side effect of radiotherapy treatment for curable breast cancer. About four in ten women treated experience fatigue, which can last for years after treatment. The impac...
Authors: N. Courtier, S. Gaze, J. Armes, A. Smith, L. Radley, J. Armytage, M. Simmonds, A. Johnson, T. Gambling and J. Hopkinson
Despite medical advances, major surgery remains high risk. Up to 44% of patients experience postoperative complications, which can have huge impacts for patients and the healthcare system. Early recognition of...
Authors: C. L. Downey, J. Croft, H. Buckley, R. Randell, J. M. Brown and D. G. Jayne
Research estimates that 30% of children under the age of 16 years in the UK live with at least one parent with an alcohol use disorder (AUD). Parental AUDs are associated with adverse childhood experiences and...
Authors: Ruth McGovern, Elaine Stamp, Mehdi Javanbakht, Elaine McColl, Matthew Hickman and Eileen Kaner
Socially disadvantaged men are at high risk of suffering from alcohol-related harm. Disadvantaged groups are less likely to engage with health promotion. There is a need for interventions that reach large numb...
Authors: Linda Irvine, Ambrose J. Melson, Brian Williams, Falko F. Sniehotta, Gerry Humphris and Iain K. Crombie
An estimated 17,000 patients are treated annually in the UK with radical radiotherapy (RT) for pelvic cancer. New treatment approaches in RT have increased survivorship and changed the subjective toxicity prof...
Authors: Patricia Holch, Simon Pini, Ann M. Henry, Susan Davidson, Jacki Routledge, Julia Brown, Kate Absolom, Alexandra Gilbert, Kevin Franks, Claire Hulme, Carolyn Morris and Galina Velikova
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in children, and currently, there are no FDA-approved therapies. Plasminogen activator inhibitor-1 (PAI-1) is elevated in children with...
Authors: Miriam B. Vos, Ran Jin, Juna V. Konomi, Rebecca Cleeton, Jessica Cruz, Saul Karpen, Dellys Soler Rodriguez, Jennifer K. Frediani, Courtney McCracken and Jean Welsh
Worldwide caesarean section (CS) delivery is the most common major operation. Approximately 25% of pregnant women undergo a CS in the UK for delivery of their babies. Sepsis and post-natal infection constitute...
Authors: V. Hodgetts Morton, A. Wilson, C. Hewitt, A. Weckesser, N. Farmer, D. Lissauer, P. Hardy and R. K. Morris
Physical activity (PA) programmes effective under ‘research’ conditions may not be effective under ‘real-world’ conditions. A potential solution is to refer patients to existing PA community-based PA services.
Authors: Gill Hubbard, Anna Campbell, Abi Fisher, Michelle Harvie, Wendy Maltinsky, Russell Mullen, Elspeth Banks, Jackie Gracey, Trish Gorely, Julie Munro and Gozde Ozakinci
Pilot trials are miniature researches carried out with the sole aim of acting as the precursor for larger more definitive studies. Abstracts are used to summarize and introduce the findings to the reading audi...
Authors: Godsent C. Isiguzo, Moleen Zunza, Maxwell Chirehwa, Bongani M. Mayosi and Lehana Thabane
Although supported self-management is a well-recognised part of chronic disease management, it has not been routinely used as part of healthcare for adults with a learning disability. We developed an intervent...
Authors: Allan House, Gary Latchford, Amy M. Russell, Louise Bryant, Judy Wright, Elizabeth Graham, Alison Stansfield and Ramzi Ajjan
Evaluations of complex interventions in public health are frequently undermined by problems that can be identified before the effectiveness study stage. Exploratory studies, often termed pilot and feasibility ...
Authors: Britt Hallingberg, Ruth Turley, Jeremy Segrott, Daniel Wight, Peter Craig, Laurence Moore, Simon Murphy, Michael Robling, Sharon Anne Simpson and Graham Moore
Sedentary behaviour (sitting) is a highly prevalent negative health behaviour, with individuals of all ages exposed to environments that promote prolonged sitting. Excessive sedentary behaviour adversely affec...
Authors: Stacy A. Clemes, Daniel D. Bingham, Natalie Pearson, Yu-Ling Chen, Charlotte Edwardson, Rosemary McEachan, Keith Tolfrey, Lorraine Cale, Gerry Richardson, Mike Fray, Stephan Bandelow, Nishal Bhupendra Jaicim, Jo Salmon, David Dunstan and Sally E. Barber
Since the introduction of the Teenage Pregnancy Strategy (TPS), England’s under-18 conception rate has fallen by 55%, but a continued focus on prevention is needed to maintain and accelerate progress. The teen...
Authors: Ruth Ponsford, Elizabeth Allen, Rona Campbell, Diana Elbourne, Alison Hadley, Maria Lohan, G. J. Melendez-Torres, Catherine H. Mercer, Steve Morris, Honor Young and Chris Bonell
Botulinum toxin-A is provided for adults with post-stroke spasticity. Following injection, there is a variation in the rehabilitation therapy type and amount provided. The purpose of this study was to determin...
Authors: Natasha A. Lannin, Louise Ada, Tamina Levy, Coralie English, Julie Ratcliffe, Doungkamol Sindhusake and Maria Crotty
Pulmonary arterial hypertension (PAH) is an uncommon condition with progressive heart failure and premature death. Treatment costs up to £120,000 per patient per year, and the psychological burden of PAH is su...
Authors: R. M. R. Tulloh, V. Garratt, J. Tagney, J. Turner-Cobb, E. Marques, R. Greenwood, L. Howard, W. Gin-Sing, A. Barton, P. Ewings, P. Craggs and W. Hollingworth
The HOMEONE study is part of the larger HOME project, which aims to provide evidence of diagnostic and therapeutic yield (“change of management”) of a patient-controlled portable EEG device with dry electrodes fo...
Authors: Thomas Neumann, Anne Katrin Baum, Ulrike Baum, Renate Deike, Helmut Feistner, Hermann Hinrichs, Joseph Stokes and Bernt-Peter Robra
Remote biomonitoring of vital parameters in hospitals and homes has the potential to improve coverage and quality of maternal and neonatal health. Wearable sensors coupled with modern information and communica...
Authors: Suman Rao, Prashanth Thankachan, Bharadwaj Amrutur, Maryann Washington and Prem K. Mony
Increasing importance is being placed on optimizing the role of Nursing Aides (NAs) in improving quality of care for nursing home (NH) residents. One approach to do so is to have NAs participate in assessments...
Authors: Veronique M. Boscart, George Heckman, Meaghan Davey, Michelle Heyer and John P. Hirdes
