Articles

Vestibular rehabilitation for persons with stroke and concomitant dizziness—a pilot study

Dizziness is common among patients with first time stroke. It affects self-perceived health and is a risk factor for falls. Vestibular rehabilitation (VR) is effective for treating dizziness among various cond...

Authors: Eva Ekvall Hansson, Hélène Pessah-Rasmussen, Annika Bring, Birgit Vahlberg and Liselott Persson

Acupuncture for knee osteoarthritis with sensitized acupoints: results from a pilot, feasibility randomized controlled trial

Although previous clinical studies suggest possible benefits of acupuncture for knee osteoarthritis (KOA), the value of acupuncture at sensitized points is uncertain. We aimed to preliminarily assess the feasi...

Authors: Pengli Jia, Jiali Liu, Ling Li, Yanan Luo, Ying Li, Ling Zhao, Fanrong Liang, Zhibin Liu, Kang Zou, Li Tang and Xin Sun

Implementing nudges for suicide prevention in real-world environments: project INSPIRE study protocol

Suicide is a global health issue. There are a number of evidence-based practices for suicide screening, assessment, and intervention that are not routinely deployed in usual care settings. The goal of this stu...

Authors: Molly Davis, Courtney Benjamin Wolk, Shari Jager-Hyman, Rinad S. Beidas, Jami F. Young, Jennifer A. Mautone, Alison M. Buttenheim, David S. Mandell, Kevin G. Volpp, Katherine Wislocki, Anne Futterer, Darby Marx, E. L. Dieckmeyer and Emily M. Becker-Haimes

HALT (Hernia Active Living Trial): protocol for a feasibility study of a randomised controlled trial of a physical activity intervention to improve quality of life in people with bowel stoma with a bulge/parastomal hernia

Parastomal hernia (PSH) can be repaired surgically, but results to date have been disappointing, with reported recurrence rates of 30 to 76%. Other types of intervention are therefore needed to improve the qua...

Authors: Gill Hubbard, Rebecca J. Beeken, Claire Taylor, Raymond Oliphant, Angus J. M. Watson, Julie Munro, Sarah Russell and William Goodman

A randomised feasibility trial of an intervention to support sharing of HIV status for 18–25-year olds living with perinatally acquired HIV compared with standard care: HIV Empowering Adults’ Decisions to Share—UK/Uganda Project (HEADS-UP)

Young adults with perinatally acquired HIV (PAH) face several challenges, including adhering to antiretroviral therapy (ART), managing the risk of onward HIV transmission and maintaining positive well-being. S...

Authors: Michael Evangeli, Caroline Foster, Victor Musiime, Sarah Fidler, Janet Seeley and Georgina Gnan

Feasibility of preoperative tattooing of percutaneously biopsied axillary lymph node: an experimental pilot study

In the last three decades, axillary lymph node dissection (ALND) has been replaced by sentinel lymph node biopsy (SLNB) in all clinically node-negative patients. However, when SLNB alone is performed in clinic...

Authors: Abida K. Sattar, Basim Ali, Imrana Masroor, Shaista Afzal, Mohammad Usman Tariq, Romana Idrees, Maseeh Uzzaman and Wardah Khalid

Design, rationale and analysis plan for the Stand Up for Health trial in contact centres: a stepped wedge feasibility study

Contact centres are one of the most sedentary workplaces, with employees spending a very high proportion of their working day sitting down. About a quarter of contact centre staff regularly experience musculos...

Authors: Richard A. Parker, Jillian Manner, Divya Sivaramakrishnan, Graham Baker, Andrew Stoddart, Scott Lloyd and Ruth Jepson

The feasibility of an innovative GP-physiotherapist partnership to identify and manage chronic obstructive pulmonary disease (INTEGRATED): study protocol

Chronic obstructive pulmonary disease (COPD) contributes significantly to mortality, hospitalisations and health care costs worldwide. There is evidence that the detection, accurate diagnosis and management of...

Authors: Lisa Pagano, Zoe McKeough, Sally Wootton, Stephen Crone, Deborah Pallavicini, Andrew S. L. Chan, Sriram Mahadev, Nicholas Zwar and Sarah Dennis

Evaluation of a manualised speech and language therapy programme for children with social communication disorder: the SCIP feasibility study

Children with Social (Pragmatic) Communication Disorder (SPCD) have long-term needs in using and processing social language and have a high risk of later mental health difficulties. A manualised speech and lan...

Authors: Catherine Adams, Jacqueline Gaile, Hazel Roddam, Janet Baxendale, Laura Clitheroe and Richard Emsley

Implementing combined WHO mhGAP and adapted group interpersonal psychotherapy to address depression and mental health needs of pregnant adolescents in Kenyan primary health care settings (INSPIRE): a study protocol for pilot feasibility trial of the integrated intervention in LMIC settings

Addressing adolescent pregnancies associated health burden demands new ways of organizing maternal and child mental health services to meet multiple needs of this group. There is a need to strengthen integrati...

Authors: Manasi Kumar, Keng-Yen Huang, Caleb Othieno, Dalton Wamalwa, Kimberly Hoagwood, Jurgen Unutzer, Shekhar Saxena, Inge Petersen, Simon Njuguna, Beatrice Amugune, Onesmus Gachuno, Fred Ssewamala and Mary McKay

Mood, Activity Participation, and Leisure Engagement Satisfaction (MAPLES): a randomised controlled pilot feasibility trial for low mood in acquired brain injury

Acquired brain injury (ABI) affects approximately 79.3 million individuals annually and is linked with elevated rates of depression and low mood. Existing methods for treating depression in ABI have shown mixe...

Authors: Andrea Kusec, Fionnuala C. Murphy, Polly V. Peers, Cara Lawrence, Emma Cameron, Claire Morton, Andrew Bateman, Peter Watson and Tom Manly

Assessing the acceptability of a text messaging service and smartphone app to support patient adherence to medications prescribed for high blood pressure: a pilot study

This paper describes a pilot non-randomised controlled study of a highly tailored 56-day text messaging and smartphone app prototype intervention to increase adherence to anti-hypertensive medication in primar...

Authors: Aikaterini Kassavou, Charlotte Emily A’Court, Jagmohan Chauhan, James David Brimicombe, Debi Bhattacharya, Felix Naughton, Wendy Hardeman, Cecilia Mascolo and Stephen Sutton

An app-, web- and social support-based weight loss intervention for adults with obesity: the ‘HelpMeDoIt!’ feasibility randomised controlled trial

Social support has an important role in successful weight loss. The aim of this study was to assess the feasibility and acceptability of an app-, web- and social support-based intervention in supporting adults...

Authors: Sharon Anne Simpson, Lynsay Matthews, Juliana Pugmire, Alex McConnachie, Emma McIntosh, Elinor Coulman, Kathryn Hughes, Mark Kelson, Sarah Morgan-Trimmer, Simon Murphy, Olga Utkina-Macaskill and Laurence Anthony Russell Moore

A mixed methods evaluation of the feasibility, acceptability, and impact of a pilot project ECHO for community health workers (CHWs)

Despite the positive effects of community health workers (CHWs) on addressing social determinants of health, improving patient health outcomes, and decreasing overall healthcare costs, there is a lack of stand...

Authors: April Joy Damian, Sarafina Robinson, Faaiza Manzoor, Mandy Lamb, Adriana Rojas, Ariel Porto and Daren Anderson

Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study

The life expectancy for people with sickle cell disease (SCD) has improved tremendously over the last 50 years. This population experiences hemolysis and vaso-occlusion in multiple organs that lead to complica...

Authors: Charity I. Oyedeji, Katherine Hall, Alison Luciano, Miriam C. Morey and John J. Strouse

A mixed methods randomised feasibility trial investigating the management of benign paroxysmal positional vertigo in acute traumatic brain injury

Traumatic brain injury (TBI) is the leading cause of long-term disability in working age adults. Recent studies show that most acute TBI patients demonstrate vestibular features of dizziness and imbalance, oft...

Authors: Rebecca M. Smith, Natalie Marroney, Jenna Beattie, Abby Newdick, Vassilios Tahtis, Caroline Burgess, Jonathan Marsden and Barry M. Seemungal

Feasibility of the PalliSupport care pathway: results from a mixed-method study in acutely hospitalized older patients at the end of life

A transitional care pathway (TCP) could improve care for older patients in the last months of life. However, barriers exist such as unidentified palliative care needs and suboptimal collaboration between care ...

Authors: Isabelle Flierman, Marjon van Rijn, Marike de Meij, Marjolein Poels, Dorende M. Niezink, Dick L. Willems and Bianca M. Buurman

Online prenatal trial in mindfulness sleep management (OPTIMISM): protocol for a pilot randomized controlled trial

Sleep deficiency affects a majority of pregnant women with significant impact on daily function, mood, and pregnancy and birth outcomes. This ongoing study combines two evidence-based strategies for improving ...

Authors: Ira Kantrowitz-Gordon, Susan M. McCurry, Carol A. Landis, Rachel Lee and Dahee Wi

Evaluation of a clinical pharmacist team-based telehealth intervention in a rural clinic setting: a pilot study of feasibility, organizational perceptions, and return on investment

Remote, centralized clinical pharmacist services provided by board-certified clinical pharmacists have been shown to effectively assist in chronic disease management. We assess the feasibility of implementing ...

Authors: Logan T. Murry, Christopher P. Parker, Rachel J. Finkelstein, Matthew Arnold and Korey Kennelty

Feasibility and acceptability of a televideo physical activity and nutrition program for recent kidney transplant recipients

Post-transplant weight gain affects 50–90% of kidney transplant recipients adversely affecting survival, quality of life, and risk for diabetes and cardiovascular disease. Diet modification and physical activi...

Authors: Cheryl A. Gibson, Aditi Gupta, J. Leon Greene, Jaehoon Lee, Rebecca R. Mount and Debra K. Sullivan

Improving maternal and fetal pregnancy outcomes: in memoriam, Doctor Frederick Morfaw (1980-2020)

Authors: Lawrence Mbuagbaw and Lehana Thabane

Mind the gap: an intervention to support caregivers with a new autism spectrum disorder diagnosis is feasible and acceptable

Children with autism spectrum disorder (ASD) benefit when their caregivers can effectively advocate for appropriate services. Barriers to caregiver engagement such as provider mistrust, cultural differences, s...

Authors: Suzannah Iadarola, Melanie Pellecchia, Aubyn Stahmer, Hyon Soo Lee, Lindsay Hauptman, Elizabeth McGhee Hassrick, Samantha Crabbe, Sarah Vejnoska, Elizabeth Morgan, Heather Nuske, Paul Luelmo, Chris Friedman, Connie Kasari, Amanda Gulsrud, David Mandell and Tristram Smith

Improving patient experience and safety at transitions of care through the Your Care Needs You (YCNY) intervention: a study protocol for a cluster randomised controlled feasibility trial

Patients, particularly older people, often experience safety issues when transitioning from hospital to home. Although the evidence is currently equivocal as to how we can improve this transition of care, inte...

Authors: Ruth Baxter, Jenni Murray, Jane K. O’Hara, Catherine Hewitt, Gerry Richardson, Sarah Cockayne, Laura Sheard, Thomas Mills and Rebecca Lawton

Developing a theory-based multimedia intervention for schools to improve young people’s asthma: my asthma in school (MAIS)

Asthma control in adolescents is low with half of the young people in a London study identified as having suboptimal control when measured using the Asthma Control Test. Control of asthma symptoms can be impro...

Authors: Gioia Mosler, Katherine Harris, Jonathan Grigg and Liz Steed

Oral prednisolone for acute otitis media in children: a pilot, pragmatic, randomised, open-label, controlled study (OPAL study)

Acute otitis media (AOM) is associated with high antibiotic prescribing rates. Antibiotics are somewhat effective in improving pain and middle ear effusion (MEE); however, they have unfavourable effects. Alter...

Authors: Respati W. Ranakusuma, Amanda R. McCullough, Eka D. Safitri, Yupitri Pitoyo, Widyaningsih Widyaningsih, Christopher B. Del Mar and Elaine M. Beller

Development and feasibility of a tailored habit-based dietary intervention coupled with natural tooth replacement on the nutritional status of older patients

Older adults suffering partial tooth loss may need additional intervention strategies other than natural tooth replacement alone to improve their nutritional status. This study aimed to design and develop a ha...

Authors: Leigh-Ann McCrum, Sinead Watson, Laura McGowan, Bernadette McGuinness, Christopher Cardwell, Mike Clarke, Jayne V. Woodside and Gerry McKenna

Feasibility and predictors of change of narrative exposure therapy for displaced populations: a repeated measures design

Displaced victims of interpersonal violence, such as refugees, asylum seekers, and victims of sexual exploitation, are growing in numbers and are often suffering from a post-traumatic stress disorder (PTSD). A...

Authors: Rina S. Ghafoerkhan, Henriette E. van Heemstra, Willem F. Scholte, Joriene R. J. van der Kolk, Jackie June F. ter Heide, Simone M. de la Rie, Linda M. Verhaak, Evelien Snippe and Paul A. Boelen

Problem-solving therapy rather than treatment as usual for adults after self-harm: a pragmatic, feasibility, randomised controlled trial (the MIDSHIPS trial)

Non-fatal self-harm is one of the commonest reasons for adults’ emergency hospital attendance. Although strongly associated with fatal and non-fatal repetition, there is weak evidence about effective intervent...

Authors: David Owens, Alexandra Wright-Hughes, Liz Graham, Paul Blenkiron, Kayleigh Burton, Michelle Collinson, Amanda Farrin, Simon Hatcher, Katie Martin, John O’Dwyer, Louise Pembroke, David Protheroe, Sandy Tubeuf and Allan House

A web-based educational intervention to implement trauma-informed care in a paediatric healthcare setting: protocol for a feasibility study using pre-post mixed methods design

Adoption of responsive trauma-informed practices by staff in hospital-based paediatric care may help mitigate downstream costs associated with treatment delivery due to reduced pain and distress for children a...

Authors: Megan Simons, Alexandra De Young, Steven M. McPhail, Gillian Harvey, Justin Kenardy, Sanjeewa Kularatna, Roy Kimble and Zephanie Tyack

Exploring community perceptions in preparation for a randomised controlled trial of biofortified flour in Pakistan

Biofortification of staple food crops may be a cost-effective and sustainable approach to reducing micronutrient deficiencies in resource-poor settings with low dietary diversity. However, its success depends ...

Authors: Usman Mahboob, Heather Ohly, Edward J. M. Joy, Victoria Moran, Mukhtiar Zaman and Nicola M. Lowe

Self-administration of medication during hospitalization—a randomized pilot study

Self-administration of medication (SAM) during hospitalization is a complex intervention where patients are involved in their course of treatment. The study aim was to pilot test the SAM intervention. The obje...

Authors: Charlotte Arp Sørensen, Charlotte Olesen, Marianne Lisby, Ulrika Enemark and Annette de Thurah

A co-production approach guided by the behaviour change wheel to develop an intervention for reducing sedentary behaviour after stroke

Stroke survivors are highly sedentary; thus, breaking up long uninterrupted bouts of sedentary behaviour could have substantial health benefit. However, there are no intervention strategies specifically aimed ...

Authors: Jennifer Hall, Sarah Morton, Jessica Hall, David J. Clarke, Claire F. Fitzsimons, Coralie English, Anne Forster, Gillian E. Mead and Rebecca Lawton

Peer navigation for individuals with serious mental illness leaving jail: a pilot randomized trial study protocol

Serious mental illness (SMI) is a prevalent public health problem affecting 25% of individuals in jail. Re-entry to the community following incarceration is a vulnerable time for justice-involved individuals w...

Authors: Maji Hailemariam, Lauren M. Weinstock and Jennifer E. Johnson

Prostaglandin insert dinoprostone versus trans-cervical balloon catheter for outpatient labour induction: a randomised controlled trial of feasibility (PROBIT-F)

The aim was to assess the feasibility of conducting a randomised controlled trial (RCT) of induction of labour comparing use of two methods in the outpatient setting.

Authors: Amarnath Bhide, Philip Sedgwick, Barbara Barrett, Georgina Cupples, Rose Coates, Rosie Goode, Sandra Linton and Christine McCourt

Heavy shoulder strengthening exercise in people with hypermobility spectrum disorder (HSD) and long-lasting shoulder symptoms: a feasibility study

People with hypermobility spectrum disorder (HSD) are in great risk of experiencing shoulder symptoms, but evidence for treatment is sparse. Therefore, the objective was to evaluate the feasibility of 16-week ...

Authors: Behnam Liaghat, Søren T. Skou, Uffe Jørgensen, Jens Sondergaard, Karen Søgaard and Birgit Juul-Kristensen

Pediatric size phlebotomy tubes and transfusions in adult critically ill patients: a pilot randomized controlled trial

Transfusion of red blood cells (RBC) is common, can have adverse effects, and is a costly and limited resource. Interventions that reduce iatrogenic blood losses could reduce transfusions. The objectives of th...

Authors: Javier Barreda Garcia, Jonathan Z. Xian, Claudia Pedroza, Moiz Salahuddin, Garbo Mak, Anabelle Keene, Sujith V. Cherian, Alisha Y. Young, Praveen Vijhani and Pratik B. Doshi

Study protocol: a lifestyle intervention for African American and Hispanic prostate cancer survivors on active surveillance and their partners

Prostate cancer is the most commonly diagnosed cancer in both African American and Hispanic men. Active surveillance is a treatment option for low- or very low-risk prostate cancer survivors, and lifestyle int...

Authors: Dalnim Cho, Karen Basen-Engquist, Chiara Acquati, Hilary Ma, Curtis Pettaway, Yisheng Li, Cassandra S. Diep and Lorna H. McNeill

Correction to: Feasibility and predictors of change of narrative exposure therapy for displaced populations: a repeated measures design

An amendment to this paper has been published and can be accessed via the original article.

Authors: Rina S. Ghafoerkhan, Henriette E. van Heemstra, Willem F. Scholte, Joriene R. J. van der Kolk, Jackie June F. ter Heide, Simone M. de la Rie, Linda M. Verhaak, Evelien Snippe and Paul A. Boelen

The value of real-world testing: a qualitative feasibility study to explore staff and organisational barriers and strategies to support implementation of a clinical pathway for the management of anxiety and depression in adult cancer patients

Effective translation of evidence-based research into clinical practice requires assessment of the many factors that can impact implementation success. Research methods that draw on recognised implementation f...

Authors: Liesbeth Geerligs, Heather L. Shepherd, Nicole M. Rankin, Lindy Masya, Joanne M. Shaw, Melanie A. Price, Haryana Dhillon, Colette Dolan, Gabrielle Prest and Phyllis Butow

Combining cognitive stimulation therapy and fall prevention exercise (CogEx) in older adults with mild to moderate dementia: a feasibility randomised controlled trial

People living with dementia (PLwD) have a high fall risk as cognitive impairment compromises control of gait and balance. Fall prevention exercises that are effective in healthy older adults may not work for P...

Authors: Elizabeth Binns, Ngaire Kerse, Kathy Peri, Gary Cheung and Denise Taylor

Engagement intervention versus treatment as usual for young adults with serious mental illness: a randomized pilot trial

Young adults have elevated rates of mental health disorders, yet they often do not receive consistent care. The challenge of continuing to engage young adults has been pervasive worldwide. Few engagement inter...

Authors: Michelle R. Munson, James J. Jaccard, Lionel D. Scott Jr, Sarah C. Narendorf, Kiara L. Moore, Nadia Jenefsky, Andrea Cole, Maryann Davis, Todd Gilmer, Rei Shimizu, Kristin Pleines, Kamilyah Cooper, Aaron H. Rodwin, Lindsay Hylek and Angel Amaro

Internet-based cognitive behavior therapy for problem gambling in routine care: protocol for a non-randomized pilot and feasibility trial

Problem gambling and gambling disorder are major public health concerns worldwide, and awareness of associated negative consequences is rising. In parallel, treatment demand has increased, and Internet interve...

Authors: Olof Molander, Philip Lindner, Jonas Ramnerö, Johan Bjureberg, Per Carlbring and Anne H. Berman

A single-arm feasibility study of community-delivered Baduanjin (Qigong practice of the eight Brocades) training for frail older adults

Frailty is a common geriatric syndrome, characterized by reduced physiologic reserve and increased vulnerability to stressors, due to cumulative decline in multiple physiological systems. We studied the feasib...

Authors: Xiao Liu, Jean Wei Ting Seah, Benedict Wei Jun Pang, Mary Ann Tsao, Falong Gu, Wai Chong Ng, Junie Ying Ru Tay, Tze Pin Ng and Shiou Liang Wee

Tranexamic acid and rosuvastatin in patients at risk of cardiovascular events after noncardiac surgery: a pilot of the POISE-3 randomized controlled trial

Surgical bleeding is associated with postoperative cardiovascular complications. The efficacy and safety of tranexamic acid (TXA) in noncardiac surgery are still uncertain. Statins may prevent perioperative ca...

Authors: Maura Marcucci, Emmanuelle Duceppe, Yannick Le Manach, Clive Kearon, John W. Eikelboom, Kayla Pohl, Jessica Vincent, Saeed Darvish-Kazem, Sadeesh K. Srinathan, John D. D. Neary, Joel L. Parlow, Andrea Kurz, Peter L. Gross, Marko Mrkobrada, Kumar Balasubramanian, Daniel I. Sessler…

A feasibility study of the physiotherapy management of urinary incontinence in athletic women: trial protocol for the POsITIve study

Urinary incontinence (UI) affects up to 40% of adult women within the UK, and pelvic floor muscle training can be effective as a treatment. The prevalence of UI is higher in athletic women than in their sedent...

Authors: K. Gillian Campbell, Mark E. Batt and Avril Drummond

Feasibility of a cluster randomized controlled trial on the effectiveness of peer–led health education interventions to increase uptake of retinal examination for diabetic retinopathy in Kirinyaga, Kenya: a pilot trial

People living with diabetes can reduce their risk of vision loss from diabetic retinopathy by attending screening, which enables early detection and timely treatment. The aim of this pilot trial was to assess ...

Authors: Nyawira Mwangi, Covadonga Bascaran, Mark Ng’ang’a, Jacqueline Ramke, Mathew Kipturgo, Stephen Gichuhi, Min Kim, David Macleod, Consuela Moorman, David Muraguri, Esbon Gakuo, Lawrence Muthami and Allen Foster

Safety and feasibility of a Dalcroze eurhythmics and a simple home exercise program among older adults with mild cognitive impairment (MCI) or mild dementia: the MOVE for your MIND pilot trial

Falls represent a major health problem for older adults with cognitive impairment, and the effects of exercise for fall reduction are understudied in this population. This pilot randomized controlled trial eva...

Authors: Melanie Fischbacher, Patricia Orializ Chocano-Bedoya, Ursina Meyer, Irene Bopp, Michèle Mattle, Reto Werner Kressig, Andreas Egli and Heike Annette Bischoff-Ferrari

Internet-based cognitive behavioural therapy programme as an intervention for people diagnosed with adult-onset, focal, isolated, idiopathic cervical dystonia: a feasibility study protocol

Dystonia is one of the most common forms of movement disorder, caused by the co-contraction of antagonistic muscles, leading to abnormal postures and considerable disability. Non-motor symptoms, notably psychi...

Authors: Megan E. Wadon, Mia Winter and Kathryn J. Peall

Efficacy of different load intensity and time-under-tension calf loading protocols for Achilles tendinopathy (the LOADIT trial): protocol for a randomised pilot study

Modifying variables in exercise prescription can produce specific effects on Achilles tendinopathy outcomes. This study aims to determine the feasibility of conducting an adequately powered randomised trial in...

Authors: Fatmah Hasani, Terry P. Haines, Shannon E. Munteanu, Bill Vicenzino and Peter Malliaras

A cohort study comparing internal fixation for undisplaced versus hip arthroplasty for displaced femoral neck fracture in the elderly: a pilot study for a clinical trial

The literature regarding undisplaced femoral neck fractures (FNF) is sparse. The aim of this prospective feasibility study is to compare the clinical outcome after undisplaced FNF treated with internal fixatio...

Authors: Sebastian Mukka, Pontus Sjöholm, Athir Aziz, Thomas Eisler, Bakir Kadum, Ferid Krupic, Per Morberg and Arkan Sayed-Noor