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  1. Whole-school interventions represent promising approaches to promoting adolescent sexual health, but they have not been rigorously trialled in the UK and it is unclear if such interventions are feasible for de...

    Authors: Ruth Ponsford, Rebecca Meiksin, Sara Bragg, Joanna Crichton, Lucy Emmerson, Tara Tancred, Nerissa Tilouche, Gemma Morgan, Pete Gee, Honor Young, Alison Hadley, Rona Campbell and Chris Bonell

    Citation: Pilot and Feasibility Studies 2021 7:50

    Content type: Research

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  2. Routine measurement of gastric residual volume (GRV) to guide feeding in neonatal and paediatric intensive care is widespread. However, this practice is not evidence based and may cause harm. As part of a feas...

    Authors: Elizabeth Deja, Louise Roper, Lyvonne N. Tume, Jon Dorling, Chris Gale, Barbara Arch, Lynne Latten, Nazima Pathan, Helen Eccleson, Helen Hickey, Jenny Preston, Anne Beissel, Izabela Andrzejewska, Frédéric V. Valla and Kerry Woolfall

    Citation: Pilot and Feasibility Studies 2021 7:49

    Content type: Research

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  3. We examined the utility of self-rated adherence to dietary and physical activity (PA) prescriptions as a method to monitor intervention compliance and facilitate goal setting during the Healthy Diet and Lifest...

    Authors: Holly O’Reilly, Chloe E. Panizza, Unhee Lim, Kim M. Yonemori, Lynne R. Wilkens, Yurii B. Shvetsov, Michelle N. Harvie, John Shepherd, Fengqing Maggie Zhu, Loïc Le Marchand, Carol J. Boushey and Kevin D. Cassel

    Citation: Pilot and Feasibility Studies 2021 7:48

    Content type: Research

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  4. Open tibia fractures are a major source of disability in low- and middle-income countries (LMICs) due to the high incidence of complications, particularly infection and chronic osteomyelitis. One proposed adju...

    Authors: Ericka P. von Kaeppler, Claire Donnelley, Syed H. Ali, Heather J. Roberts, John M. Ibrahim, Hao-Hua Wu, Edmund N. Eliezer, Travis C. Porco, Billy T. Haonga, Saam Morshed and David W. Shearer

    Citation: Pilot and Feasibility Studies 2021 7:47

    Content type: Study Protocol

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  5. Placebo-controlled surgical trials are recognised as the gold standard way to test the efficacy of a surgical procedure. Despite a rise in arthroscopic subacromial decompression (ASD) surgeries for the treatme...

    Authors: Elizabeth Nelson, Cade Shadbolt, Samantha Bunzli, Angela Cochrane, Peter Choong and Michelle Dowsey

    Citation: Pilot and Feasibility Studies 2021 7:46

    Content type: Study Protocol

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  6. International debate around the best models of speech and language therapy provision for children with language disorders has highlighted the need for research into classroom-based approaches and intervention ...

    Authors: Anita Rowe, Jill Titterington, Joni Holmes, Lucy Henry and Laurence Taggart

    Citation: Pilot and Feasibility Studies 2021 7:45

    Content type: Research

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  7. Non-suicidal self-injury (NSSI) has gained increased attention in recent years due to increased prevalence, especially among adolescents. Evidence-based interventions for NSSI are sparse. Emotion regulation in...

    Authors: Britt Morthorst, Lotte Rubæk, Jane Lindschou, Janus Christian Jakobsen, Christian Gluud, Johan Bjureberg, Clara Hellner, Bo Møhl and Anne Katrine Pagsberg

    Citation: Pilot and Feasibility Studies 2021 7:44

    Content type: Study Protocol

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  8. An active play is designed to increase children’s physical activity levels and fundamental movement skills through outdoor play and is well-suited to the needs of children with intellectual disabilities. Howev...

    Authors: Arlene McGarty, Nathalie Jones, Katie Rutherford, Sophie Westrop, Lara Sutherland, Andrew Jahoda and Craig Melville

    Citation: Pilot and Feasibility Studies 2021 7:43

    Content type: Research

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  9. Venous leg ulceration is a widespread, debilitating pathology with high recurrence rates. Conservative treatment using graduated compression dressings may be associated with unacceptable ulcer recurrence rates...

    Authors: Thomas M. Aherne, Colm Keohane, Matthew Mullins, Adeel S. Zafar, Stephen A. Black, Tjun Y. Tang, Gerard J. O’Sullivan and Stewart R. Walsh

    Citation: Pilot and Feasibility Studies 2021 7:42

    Content type: Study Protocol

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  10. Prior studies have shown that meal composition may affect the metabolic responses and arterial stiffness indices, and these responses may be different in lean and obese adults. The primary objective of this st...

    Authors: Safieh Firouzi, Reza Rezvani, Naseh Pahlavani, Lida Jarahi, Jamshid Gholizadeh Navashenaq, Golnaz Ranjbar, Mahsa Malekahmadi, Zhila Taherzadeh and Mohammad Safarian

    Citation: Pilot and Feasibility Studies 2021 7:41

    Content type: Study Protocol

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  11. The current CONSORT guidelines for reporting pilot trials do not recommend hypothesis testing of clinical outcomes on the basis that a pilot trial is under-powered to detect such differences and this is the ai...

    Authors: M. Lewis, K. Bromley, C. J. Sutton, G. McCray, H. L. Myers and G. A. Lancaster

    Citation: Pilot and Feasibility Studies 2021 7:40

    Content type: Methodology

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  12. Breast cancer is the leading cancer affecting women in Singapore. Its survivors commonly experience decline in physical function and quality of life post-mastectomy, due to their upper limb morbidity and wound...

    Authors: Miho Asano, Gerald Choon-Huat Koh, Preetha Madhukumar, Gladys Yu Hui Teng, Petrina Li Ling Liew, Saraswathi Nagalingam, May Leng Mabel Tan, Yee Sien Ng and Benita Kiat Tee Tan

    Citation: Pilot and Feasibility Studies 2021 7:39

    Content type: Study Protocol

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  13. Evidenced-based clinical guidelines for the treatment of low back pain (LBP) consistently suggest educating patients about their back pain, its natural course, and providing advice to keep active and continue ...

    Authors: J. Lemieux, G. Kawchuk, A. Kongsted, J. Hartvigsen, V. Abdollah and A. Jones

    Citation: Pilot and Feasibility Studies 2021 7:38

    Content type: Research

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  14. Reducing the alcohol content of drinks has the potential to reduce alcohol consumption. The aims of this study are to (1) test the feasibility of a randomised controlled trial (RCT) to assess the effect of alc...

    Authors: Parvati R. Perman-Howe, Emma L. Davies and David R. Foxcroft

    Citation: Pilot and Feasibility Studies 2021 7:37

    Content type: Research

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  15. Computerized cognitive training (CCT) programs have shown some effectiveness in alleviating cognitive symptoms in long-term cancer survivors. For patients presenting with cognitive symptoms in the early post-t...

    Authors: Samantha J. Mayo, Sean B. Rourke, Eshetu G. Atenafu, Rita Vitorino, Christine Chen and John Kuruvilla

    Citation: Pilot and Feasibility Studies 2021 7:36

    Content type: Research

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  16. Despite a high prevalence of antenatal depression in low- and middle-income countries, there is very little evidence for contextually adapted psychological interventions delivered in rural African settings. Th...

    Authors: Tesera Bitew, Roxanne Keynejad, Bronwyn Myers, Simone Honikman, Girmay Medhin, Fikirte Girma, Louise Howard, Katherine Sorsdahl and Charlotte Hanlon

    Citation: Pilot and Feasibility Studies 2021 7:35

    Content type: Study Protocol

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  17. Globally too many mothers and babies die during childbirth; 98% of maternal deaths are avoidable. Skilled clinicians can reduce these deaths; however, there is a world-wide shortage of maternity healthcare wor...

    Authors: Abi Merriel, Zione Dembo, Julia Hussein, Michael Larkin, Allan Mchenga, Aurelio Tobias, Mark Lough, Address Malata, Charles Makwenda and Arri Coomarasamy

    Citation: Pilot and Feasibility Studies 2021 7:34

    Content type: Research

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  18. There is an urgent need to improve quality of care to reduce avoidable mortality and morbidity from surgical diseases in low- and middle-income countries. Currently, there is a lack of knowledge about how evid...

    Authors: Nataliya Brima, Nick Sevdalis, K. Daoh, B. Deen, T. B. Kamara, Haja Wurie, Justine Davies and Andrew J. M. Leather

    Citation: Pilot and Feasibility Studies 2021 7:33

    Content type: Study Protocol

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  19. Depression is often underdiagnosed by treating health professionals. This is a situation in Malawi where there is no routine screening of depression at antenatal clinics. Recently, a Screening Protocol for Ant...

    Authors: Genesis Chorwe-Sungani, Modesta Mwagomba, Kazione Kulisewa, Ellen Chirwa, Diana Jere and Jennifer Chipps

    Citation: Pilot and Feasibility Studies 2021 7:32

    Content type: Study Protocol

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  20. Exercise is recommended for patients with subacromial pain. It has been suggested that good exercise adherence improves clinical outcomes. Despite this, little attention has been paid to the need for behaviour...

    Authors: Daniel H. Major, Margreth Grotle, Chris Littlewood, Jens Ivar Brox, Dagfinn Matre, Heidi V. Gallet and Yngve Røe

    Citation: Pilot and Feasibility Studies 2021 7:31

    Content type: Research

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  21. The evidence for the effectiveness of e-mental health interventions among ethnic minorities is still preliminary. This mixed methods study investigates the feasibility of a culturally adapted, guided online in...

    Authors: Ozlem Eylem, Annemieke van Straten, Leonore de Wit, Shanaya Rathod, Kamaldeep Bhui and Ad J. F. M. Kerkhof

    Citation: Pilot and Feasibility Studies 2021 7:30

    Content type: Research

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  22. Traumatic injuries are common amongst working-age adults. Survivors often experience physical and psychological problems, reduced quality of life and difficulty returning to work. Vocational rehabilitation imp...

    Authors: Denise Kendrick, Roshan das Nair, Blerina Kellezi, Richard Morriss, Jade Kettlewell, Jain Holmes, Stephen Timmons, Kay Bridger, Priya Patel, Adam Brooks, Karen Hoffman and Kathryn Radford

    Citation: Pilot and Feasibility Studies 2021 7:29

    Content type: Study Protocol

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  23. Only 55% of multidrug-resistant tuberculosis (MDR-TB) cases worldwide complete treatment, with problem substance use a risk for default and treatment failure. Nevertheless, there is little research on psychoth...

    Authors: Gregory L. Calligaro, Zani de Wit, Jacqui Cirota, Catherine Orrell, Bronwyn Myers, Sebastian Decker, Dan J. Stein, Katherine Sorsdahl and Rodney Dawson

    Citation: Pilot and Feasibility Studies 2021 7:28

    Content type: Research

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  24. To establish the feasibility and acceptability of a preoperative exercise program, and to obtain pilot data on the likely difference in key surgical outcomes to inform the sample size calculation for a full-sc...

    Authors: Daniel Steffens, Jane Young, Paula R. Beckenkamp, James Ratcliffe, Freya Rubie, Nabila Ansari, Neil Pillinger, Cherry Koh, Phillip A. Munoz and Michael Solomon

    Citation: Pilot and Feasibility Studies 2021 7:27

    Content type: Research

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  25. This pilot study explores whether large adolescent idiopathic scoliosis (AIS) curves (≥ 45°) lead to decreased frequency and quality of sport participation, lower health-related quality of life (HRQL), and mor...

    Authors: Michael Youssef, John Soliman, Sarah Burrow, Waleed Kishta, Nicole Simunovic, Andrew Duong, Olufemi R. Ayeni and Devin Peterson

    Citation: Pilot and Feasibility Studies 2021 7:26

    Content type: Research

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  26. A near-fall is defined as a loss of balance that would result in a fall if sufficient balance recovery manoeuvres are not executed. Compared to falls, near-falls and its associated balance recovery manoeuvres ...

    Authors: Shawn Leng-Hsien Soh, Chee-Wee Tan, Judith Lane, Ting-Ting Yeh and Benjamin Soon

    Citation: Pilot and Feasibility Studies 2021 7:25

    Content type: Research

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  27. Bisphenol exposure is widespread and correlated with diabetes and cardiovascular disease. Previous intervention studies have successfully lowered bisphenol exposure among women of normal weight. The primary ob...

    Authors: Todd Hagobian, Zoe Delli-Bovi, Adrian Mercado, Alyssa Bird, Megan Guy and Suzanne Phelan

    Citation: Pilot and Feasibility Studies 2021 7:24

    Content type: Research

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  28. Informal caregivers of patients with Alzheimer’s disease and related dementias (ADRD) manage a complex spectrum of patient behavioral and psychological symptoms of dementia (BPSD). Mobile health information te...

    Authors: Tyler Braly, Doris Muriathiri, Janetta C. Brown, Britain M. Taylor, Malaz A. Boustani and Richard J. Holden

    Citation: Pilot and Feasibility Studies 2021 7:23

    Content type: Study Protocol

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  29. Young adults ages 18 to 25 with first episode psychosis (FEP) have an increased risk of discontinuation antipsychotic medications and psychiatric service disengagement that lead to symptom exacerbation and det...

    Authors: Yaara Zisman-Ilani, Irene Hurford, Andrea Bowen, Mark Salzer and Elizabeth C. Thomas

    Citation: Pilot and Feasibility Studies 2021 7:22

    Content type: Study Protocol

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  30. Preliminary research has shown the effectiveness of supervised exercise-based interventions in alleviating sequela resulting from metastatic prostate cancer. Despite this, many individuals do not engage in suf...

    Authors: Holly E. L. Evans, Cynthia C. Forbes, Daniel A. Galvão, Corneel Vandelanotte, Robert U. Newton, Gary Wittert, Suzanne Chambers, Andrew D. Vincent, Ganessan Kichenadasse, Nicholas Brook, Danielle Girard and Camille E. Short

    Citation: Pilot and Feasibility Studies 2021 7:21

    Content type: Study Protocol

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  31. Unhealthy dietary patterns are highly prevalent in Western countries, and they have been associated with depression, hypertension, heart disease, cancer, type 2 diabetes, and obesity. Many dietary intervention...

    Authors: Juul M. J. Coumans, Catherine A. W. Bolman, Lilian Lechner and Anke Oenema

    Citation: Pilot and Feasibility Studies 2021 7:20

    Content type: Research

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  32. Endometriosis (where endometrial-like tissue is found outside the uterus) affects ~ 176 million women worldwide and can lead to debilitating pelvic pain. Three subtypes of endometriosis exist, with ~ 80% of wo...

    Authors: Lucy H. R. Whitaker, Ann Doust, Jacqueline Stephen, John Norrie, Kevin Cooper, Jane Daniels, Lone Hummelshoj, Emma Cox, Laura Beatty, Patrick Chien, Mayank Madhra, Katy Vincent and Andrew W. Horne

    Citation: Pilot and Feasibility Studies 2021 7:19

    Content type: Study Protocol

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  33. Older patients prescribed multiple medications commonly experience difficulties with adherence. High-quality evidence on interventions targeting older patients is lacking. Theory is rarely used to tailor adher...

    Authors: D. E. Patton, C. J. Pearce, M. Cartwright, F. Smith, C. A. Cadogan, C. Ryan, E. Clark, J. J. Francis and C. M. Hughes

    Citation: Pilot and Feasibility Studies 2021 7:18

    Content type: Research

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  34. Clinically, a distinction is made between types of rotator cuff tear, traumatic and non-traumatic, and this sub-classification currently informs the treatment pathway. It is currently recommended that patients...

    Authors: Chris Littlewood, Julia Wade, Stephanie Butler-Walley, Martyn Lewis, David Beard, Amar Rangan, Gev Bhabra, Socrates Kalogrianitis, Cormac Kelly, Saurabh Mehta, Harvinder Pal Singh, Matthew Smith, Amol Tambe, James Tyler and Nadine E. Foster

    Citation: Pilot and Feasibility Studies 2021 7:17

    Content type: Study Protocol

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  35. A variety of management options (e.g. immunotherapies, lifestyle interventions, and rehabilitation) are available for people with relapsing-remitting multiple sclerosis (RRMS). Besides coping with the diagnosi...

    Authors: Anna Barabasch, Karin Riemann-Lorenz, Christopher Kofahl, Jutta Scheiderbauer, Desiree Eklund, Ingo Kleiter, Jürgen Kasper, Sascha Köpke, Susanne Lezius, Antonia Zapf, Anne Christin Rahn and Christoph Heesen

    Citation: Pilot and Feasibility Studies 2021 7:16

    Content type: Study Protocol

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  36. As the number of people living with dementia grows, so does the need to provide them with adequate psychosocial support. Many people with dementia live at home with family carers, who also require social and e...

    Authors: Becky Dowson, Justine Schneider, Boliang Guo, Philip M. Bath, Orii McDermott, Lee J. Haywood and Martin Orrell

    Citation: Pilot and Feasibility Studies 2021 7:15

    Content type: Study Protocol

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  37. Prescription methadone or buprenorphine enables people with opioid use disorder to stop heroin use safely while avoiding withdrawal. To ensure methadone is taken as prescribed and to prevent diversion onto the...

    Authors: N. Metrebian, E. Carr, K. Goldsmith, T. Weaver, S. Pilling, J. Shearer, K. Woolston-Thomas, B. Tas, C. Cooper, C. A. Getty, R. van der Waal, M. Kelleher, E. Finch, P. Bijral, D. Taylor, J. Scott…

    Citation: Pilot and Feasibility Studies 2021 7:14

    Content type: Research

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  38. In-bed cycling is a novel modality for the initiation of early mobilization in the intensive care unit. No study has investigated its use in the critically ill, off-track post cardiac surgery population. Befor...

    Authors: Anastasia N. L. Newman, Michelle E. Kho, Jocelyn E. Harris, Nasim Zamir, Ellen McDonald, Alison Fox-Robichaud and Patricia Solomon

    Citation: Pilot and Feasibility Studies 2021 7:13

    Content type: Research

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  39. Hypoglycemic incidents in older people can cause severe health problems, enhance general age-related disabilities, and cause frailty. Little is known about incidences of hypoglycemia in older home-dwelling peo...

    Authors: Annette Bævre Larsen, Monica Hermann and Marit Graue

    Citation: Pilot and Feasibility Studies 2021 7:12

    Content type: Research

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  40. Whilst almost 50% of heart failure (HF) patients have preserved ejection fraction (HFpEF), evidence-based treatment options for this patient group remain limited. However, there is growing evidence of the pote...

    Authors: Karen Smith, Chim Lang, Jennifer Wingham, Julia Frost, Colin Greaves, Charles Abraham, Fiona C. Warren, Joanne Coyle, Kate Jolly, Jackie Miles, Kevin Paul, Patrick J. Doherty, Russell Davies, Hasnain Dalal and Rod S. Taylor

    Citation: Pilot and Feasibility Studies 2021 7:11

    Content type: Research

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  41. Cardiovascular disease (CVD) risk increases substantially during perimenopause. Latinas have a significantly worse CVD risk factor profile than non-Hispanic White women, potentially due to multiple sociocultur...

    Authors: Yamnia I. Cortés, Diane C. Berry, Krista M. Perreira, Alison Stuebe, Lee Stoner, Cheryl Woods Giscombé, Jamie Crandell, Lymarí Santíago, Latesha K. Harris and Mayra Duran

    Citation: Pilot and Feasibility Studies 2021 7:10

    Content type: Study Protocol

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  42. People with inflammatory rheumatological conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, polymyalgia rheumatica and giant cell arteritis are at an increased risk of common...

    Authors: Samantha L. Hider, Milica Bucknall, Clare Jinks, Kelly Cooke, Kendra Cooke, Erandie Ediriweera Desilva, Andrew G. Finney, Emma L. Healey, Daniel Herron, Annabelle R. Machin, Christian D. Mallen, Simon Wathall and Carolyn A. Chew-Graham

    Citation: Pilot and Feasibility Studies 2021 7:9

    Content type: Research

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  43. Home visiting is a well-supported strategy for addressing maternal and child health disparities. However, evidence-based models generally share implementation challenges at scale, including engagement and rete...

    Authors: Allison Ingalls, Allison Barlow, Elizabeth Kushman, Amanda Leonard, Lisa Martin, Precision Family Spirit Study Team, Allison L. West, Nicole Neault and Emily E. Haroz

    Citation: Pilot and Feasibility Studies 2021 7:8

    Content type: Study Protocol

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  44. Due to multimorbidity and geriatric problems, older people often require both psychosocial and medical care. Collaboration between medical and social professionals is a prerequisite to deliver high-quality car...

    Authors: Linda C. Smit, Jeroen Dikken, Nienke M. Moolenaar, Marieke J. Schuurmans, Niek J. de Wit and Nienke Bleijenberg

    Citation: Pilot and Feasibility Studies 2021 7:7

    Content type: Methodology

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  45. Prevalence of depression is increasing in young people, and there is a need to develop and evaluate behavioural interventions which may provide benefits equal to or greater than talking therapies or pharmacolo...

    Authors: N. Howlett, L. Bottoms, A. Chater, A. B. Clark, T. Clarke, L. David, K. Irvine, A. Jones, J. Jones, S. E. Mengoni, J. Murdoch, M. Pond, S. Sharma, E. J. Sims, D. A. Turner, D. Wellsted…

    Citation: Pilot and Feasibility Studies 2021 7:6

    Content type: Study Protocol

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  46. This article reports the results from a feasibility study of an intervention (‘E-PLAYS’) aimed at supporting children who experience difficulties with social communication. E-PLAYS is based around a dyadic com...

    Authors: Suzanne Murphy, Victoria Joffe, Louisa Donald, Jessica Radley, Sailaa Sunthararajah, Charlie Welch, Kerry Bell, David Messer, Sarah Crafter, Caroline Fairhurst, Belen Corbacho, Sara Rodgers and David Torgerson

    Citation: Pilot and Feasibility Studies 2021 7:5

    Content type: Research

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  47. Many evidence-based clinical decision tools are available for the diagnosis of pulmonary embolism (PE). However, these clinical decision tools have had suboptimal uptake in the everyday clinical practice in em...

    Authors: Federico Germini, Yang Hu, Sarah Afzal, Fayad Al-haimus, Srikanth A. Puttagunta, Saghar Niaz, Teresa Chan, Natasha Clayton, Shawn Mondoux, Lehana Thabane and Kerstin de Wit

    Citation: Pilot and Feasibility Studies 2021 7:4

    Content type: Research

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  48. Accumulating evidence supports the role of a Mediterranean diet (MD) in cognition, with a greater adherence to a MD associated with reduced dementia risk. It is important to understand how best to achieve beha...

    Authors: Andrea M. McGrattan, Claire T. McEvoy, Aswathy Vijayakumar, Sarah E. Moore, Charlotte E. Neville, Bernadette McGuinness, Michelle C. McKinley and Jayne V. Woodside

    Citation: Pilot and Feasibility Studies 2021 7:3

    Content type: Research

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  49. Balance, mobility impairments and falls are problematic for people with multiple sclerosis (MS). The “Balance Right in MS (BRiMS)” intervention, a 13-week home and group-based exercise and education programme,...

    Authors: H. Gunn, K. N. Stevens, S. Creanor, J. Andrade, L. Paul, L. Miller, C. Green, P. Ewings, A. Barton, M. Berrow, J. Vickery, B. Marshall, J. Zajicek and J. A. Freeman

    Citation: Pilot and Feasibility Studies 2021 7:2

    Content type: Research

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  50. Cystic fibrosis (CF) is a life-limiting genetic condition in which daily therapies to maintain lung health are critical, yet treatment adherence is low. Previous interventions to increase adherence have been l...

    Authors: M. A. Arden, M. Hutchings, P. Whelan, S. J. Drabble, D. Beever, J. M. Bradley, D. Hind, J. Ainsworth, C. Maguire, H. Cantrill, A. O’Cathain and M. Wildman

    Citation: Pilot and Feasibility Studies 2021 7:1

    Content type: Research

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