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  1. One in five patients experience chronic pain 1 year after total knee arthroplasty (TKA), highlighting the need for enhanced treatment strategies to improve outcomes. This feasibility trial aimed to optimize th...

    Authors: Turid Rognsvåg, Ingvild Buset Bergvad, Ove Furnes, Kari Indrekvam, Anners Lerdal, Maren Falch Lindberg, Søren T Skou, Jan Stubberud and Mona Badawy
    Citation: Pilot and Feasibility Studies 2024 10:43
  2. Impaired brain bioenergetics is a pathological hallmark of Alzheimer’s disease (AD) and is a compelling target for AD treatment. Patients with AD exhibit dysfunction in the brain creatine (Cr) system, which is...

    Authors: Matthew K. Taylor, Jeffrey M. Burns, In-Young Choi, Trent J. Herda, Phil Lee, Aaron N. Smith, Debra K. Sullivan, Russell H. Swerdlow and Heather M. Wilkins
    Citation: Pilot and Feasibility Studies 2024 10:42
  3. Adult smoking rates in the USA are highest in economically depressed rural Appalachia. Pharmacist-delivered tobacco cessation support that incorporates medication therapy management (such as the QuitAid interv...

    Authors: Melissa A. Little, Taylor Reid, Matthew Moncrief, Wendy Cohn, Kara P. Wiseman, Candace H. Wood, Wen You, Roger T. Anderson and Rebecca A. Krukowski
    Citation: Pilot and Feasibility Studies 2024 10:41
  4. Even without weight loss, adults with obesity can greatly benefit from regular physical activity. The Physical Activity Self-efficacy (PAS) intervention is an online behavioral intervention newly developed to ...

    Authors: Seungmin Lee, Kevin Lahoda, Nicholas D. Myers, Andrew Horowitz, Kenneth Chiu, Lina Begdache and Eldad Einav
    Citation: Pilot and Feasibility Studies 2024 10:40
  5. Total knee arthroplasty is a common surgery for end-stage knee osteoarthritis. Partial knee arthroplasty is also a treatment option for patients with arthritis present in only one or two knee compartments. Par...

    Authors: Kim Madden, Breanne Flood, Monica Malek, Vincent Milantoni, Janie L. Astephen Wilson, Jean-Eric Tarride, Vickas Khanna and Anthony Adili
    Citation: Pilot and Feasibility Studies 2024 10:39
  6. Acquired brain injury (ABI) and other chronic conditions are placing unprecedented pressure on healthcare systems. In the UK, 1.3 million people live with the effects of brain injury, costing the UK economy ap...

    Authors: Zoe Fisher, Susannah Field, Deb Fitzsimmons, Hayley Hutchings, Kym Carter, Daniel Tod, Fergus Gracey, Alec Knight and Andrew H. Kemp
    Citation: Pilot and Feasibility Studies 2024 10:38
  7. Social isolation and low levels of physical activity are strong drivers for frailty, which is linked to poor health outcomes and transition to long-term care. Frailty is multifactorial, and thus an integrated ...

    Authors: Mei Ling Lim, Christine Zammit, Ebony Lewis, Nicole Ee, Genevieve Maiden, Micah Goldwater, Eva Kimonis, Gail Kenning, Kenneth Rockwood, Anneke Fitzgerald, Katrina Radford, Hiroko Dodge, Stephanie A. Ward, Kim Delbaere and Ruth Peters
    Citation: Pilot and Feasibility Studies 2024 10:37
  8. Catheter ablation for atrial fibrillation is recommended for symptomatic patients after failed medical therapy. Ablation has a higher failure rate in obese patients, and both the prevalence of atrial fibrillat...

    Authors: Kyaw Z. Win, Matthew Armstrong, Richard P. Steeds and Manish Kalla
    Citation: Pilot and Feasibility Studies 2024 10:36
  9. Rates of compulsory (also known as involuntary) detention under mental health legislation have been rising over several decades in countries including England. Avoiding such detentions should be a high priorit...

    Authors: Sonia Johnson, Mary Birken, Patrick Nyikavaranda, Ariana Kular, Rafael Gafoor, Jordan Parkinson, Chloe Hutchings-Hay, Thomas Gant, Jazmin Molai, Jessica Rivera, James Fenwick, Caroline Bendall, Louise Blakley, Theresa Bacarese-Hamilton, Valerie Christina White, Mark Keith Holden…
    Citation: Pilot and Feasibility Studies 2024 10:35
  10. Children are spending less leisure time with their friends in person and an increasing amount of time with digital screens. These changes may negatively affect children’s physical and mental health. The Screen-Fr...

    Authors: Sarah Overgaard Sørensen, Kristian Traberg Larsen, Teresa Victoria Høy, Anders Blædel Gottlieb Hansen, Russell Jago, Peter Lund Kristensen, Mette Toftager, Anders Grøntved and Anne Kær Gejl
    Citation: Pilot and Feasibility Studies 2024 10:33
  11. Severe mental ill health (SMI) includes schizophrenia, bipolar disorder and schizoaffective disorder and is associated with premature deaths when compared to people without SMI. Over 70% of those deaths are at...

    Authors: Gareth Jones, Laura Bailey, Rebecca J. Beeken, Samantha Brady, Cindy Cooper, Robert J. Copeland, Suzanne Crosland, Sam Dawson, Matthew Faires, Simon Gilbody, Holly Haynes, Andrew Hill, Emily Hillison, Michelle Horspool, Ellen Lee, Jinshuo Li…
    Citation: Pilot and Feasibility Studies 2024 10:32
  12. Having a strong connection to culture and Country is fundamental to the health and wellbeing of Australian Aboriginal children. The aim of the research was to evaluate the feasibility of study methods and prog...

    Authors: Rebecca M. Stanley, Anthony McKnight, Yasmine Probst, Gabrielle O’Flynn and Sarah Tillott
    Citation: Pilot and Feasibility Studies 2024 10:31
  13. Knee arthritis is a leading cause of limited function and long-term disability in older adults. Despite a technically successful total knee arthroplasty (TKA), around 20% of patients continue to have persistin...

    Authors: Kim Madden, Sushmitha Pallapothu, Darren Young Shing, Anthony Adili, Mohit Bhandari, Lisa Carlesso, Moin Khan, Ydo V. Kleinlugtenbelt, Adrijana Krsmanovic, Matilda Nowakowski, Tara Packham, Eric Romeril, Jean-Eric Tarride, Lehana Thabane, Daniel M. Tushinski, Christine Wallace…
    Citation: Pilot and Feasibility Studies 2024 10:30
  14. An advanced cancer diagnosis can be associated with a significant profile of distress. Psychedelic compounds have shown clinically significant effects in the treatment of psychological distress in patients wit...

    Authors: Alesha Wells, A. P. Suresh Muthukumaraswamy, Eva Morunga, Will Evans, Alana Cavadino, Mahima Bansal, Nicola J. Lawrence, Amanda Ashley, Nicholas R. Hoeh, Frederick Sundram, Allison J. Applebaum, Hineatua Parkinson and Lisa Reynolds
    Citation: Pilot and Feasibility Studies 2024 10:29
  15. Approximately 7.5 million older adults are homebound, who have difficulty and/or need assistance to leave their homes. In this growing population, the prevalence of people living with dementia (PLWD) is approx...

    Authors: Maimouna Sy, Ayush Thacker, Orla C. Sheehan, Bruce Leff and Christine Seel Ritchie
    Citation: Pilot and Feasibility Studies 2024 10:28
  16. Temporomandibular disorders (TMD) are a collective term for pain and dysfunction of the masticatory muscles and the temporomandibular joints. The most common types of TMD are pain-related, which may impact the...

    Authors: Lea S. Prott, Frank A. Spitznagel, Alfons Hugger, Robert Langner, Petra C. Gierthmühlen and Mortimer Gierthmühlen
    Citation: Pilot and Feasibility Studies 2024 10:27
  17. Various service provision models for youth at risk of homelessness have been researched and implemented, including access to housing and physical and mental health resources. However, even with these intervent...

    Authors: Akshya Vasudev, Emily Ionson, Janani Sathiaselan, Anurag Thatipalli, Aman Chauhan, Christine Hassan, Javeed Sukhera, Mark Speechley and Cheryl Forchuk
    Citation: Pilot and Feasibility Studies 2024 10:26
  18. Family carers play a crucial role in supporting the health and well-being of people with intellectual disabilities. Given their role and responsibilities, many family carers experience significant and ongoing ...

    Authors: Mark A. Linden, Rachel Leonard, Trisha Forbes, Michael Brown, Lynne Marsh, Stuart Todd, Nathan Hughes and Maria Truesdale
    Citation: Pilot and Feasibility Studies 2024 10:25
  19. Many patients with posttraumatic stress disorder (PTSD) suffer from sleep problems. Robot-based interventions might be an innovative approach to reduce sleep problems and hyperarousal in PTSD. However, the fea...

    Authors: Annett Lotzin and Isabelle Laskowsky
    Citation: Pilot and Feasibility Studies 2024 10:24
  20. Long-term sickness costs businesses in the United Kingdom (UK) approximately £7 billion per annum. Most long-term sickness absences are attributed to common mental health conditions, which are also highly prev...

    Authors: Oliver Davis, Jeremy Dawson, Lizzie Degerdon, Jaime Delgadillo, Umesh Kadam, Karina Nielsen, Alice Sinclair, Jo Yarker and Fehmidah Munir
    Citation: Pilot and Feasibility Studies 2024 10:23
  21. In rural and remote South Africa, most strokes and ischaemic heart diseases are as a consequence of hypertension, which is a modifiable risk factor. The widely recommended therapeutic approaches to control hyp...

    Authors: Kganetso Sekome, Francesc Xavier Gómez-Olivé, Lauren B. Sherar, Dale W. Esliger and Hellen Myezwa
    Citation: Pilot and Feasibility Studies 2024 10:22
  22. Given the dire need for health and rehabilitation services internationally, exacerbated during the COVID-19 pandemic, there is a critical need to develop tools to support service delivery. This need is palpabl...

    Authors: Harsha Kathard, Rizwana Mallick, Tracey-lee Cloete, Anthea Hansen and Lehana Thabane
    Citation: Pilot and Feasibility Studies 2024 10:21
  23. Persons with inflammatory bowel diseases are at increased risk of developing colorectal cancer and require frequent colonoscopy surveillance. Guidelines recommend taking 30 to 40 non-targeted biopsies througho...

    Authors: Sanjay K. Murthy, Luba Marderfeld, Dean Fergusson, Tim Ramsay, Charles N. Bernstein, Geoffrey C. Nguyen, Vipul Jairath and Robert Riddell
    Citation: Pilot and Feasibility Studies 2024 10:20
  24. Evaluating the effectiveness of early years parenting interventions provides evidence to improve the development and wellbeing of children. This protocol paper describes a study to explore the feasibility of e...

    Authors: Kate E. Mooney, Charlie Welch, Kirsty Crossley, Tracey Bywater, John Wright, Josie Dickerson and Sarah Blower
    Citation: Pilot and Feasibility Studies 2024 10:19
  25. Authors: Kelly Rose‑Clarke, Damodar Rimal, Joanna Morrison, Indira Pradhan, John Hodsoll, Gerard Abou Jaoude, Brian Moore, Louise Banham, Justin Richards, Mark Jordans, Audrey Prost, Nabin Lamichhane, Jaya Regmee, Kamal Gautam and Nagendra P. Luitel
    Citation: Pilot and Feasibility Studies 2024 10:18

    The original article was published in Pilot and Feasibility Studies 2023 9:149

  26. Abdominal aortic aneurysm (AAA) is an important cardiovascular health problem. Ultrasound screening is proven to reduce AAA mortality and programmes have been implemented in some healthcare systems. Those who ...

    Authors: Tom M. Withers, Colin J. Greaves, Matt J. Bown and Athanasios Saratzis
    Citation: Pilot and Feasibility Studies 2024 10:17
  27. Spinal stenosis is the most common reason for elective spine surgery, and the cardinal symptom is leg pain and discomfort when walking. Patients with spinal stenosis have a decreased level of physical activity...

    Authors: Emelie Karlsson, Rikard Hanafi, Helena Brisby, Andreas Fors, Mike Kemani, Håkan Hedman, Jo Nijs and Mari Lundberg
    Citation: Pilot and Feasibility Studies 2024 10:16
  28. The purpose of this 6-month intervention pilot feasibility randomised trial was to test sending brief messages using mobile phones to promote self-management through taking medication as prescribed to people w...

    Authors: Andrew J. Farmer, Julie Allen, Y. Kiera Bartlett, Peter Bower, Yuan Chi, David P. French, Bernard Gudgin, Emily Holmes, Robert Horne, Dyfrig A. Hughes, Louise Jones, Cassandra Kenning, Louise Locock, Jennifer McSharry, Lisa Miles, Nicola Newhouse…
    Citation: Pilot and Feasibility Studies 2024 10:15
  29. The rising prevalence of adolescent mild depression in the UK and the paucity of evidence-based interventions in non-specialist sectors where most cases present, creates an urgent need for early psychological ...

    Authors: Thando Katangwe-Chigamba, Jamie Murdoch, Paul Wilkinson, Viktoria Cestaro, Carys Seeley, Eirini Charami-Roupa, Tim Clarke, Aoife Dunne, Brioney Gee, Sharon Jarrett, Andrew Laphan, Susie McIvor, Richard Meiser-Stedman, Thomas Rhodes, Lee Shepstone, David A. Turner…
    Citation: Pilot and Feasibility Studies 2024 10:14
  30. Nutrition-related factors linked to pain chronicity and disability include weight status and dietary behaviours. Dietary patterns associated with concurrent pain episodes, however, remain poorly characterised....

    Authors: Susan J. Ward, Alison M. Coates, Katherine L. Baldock, Carolyn Berryman and Alison M. Hill
    Citation: Pilot and Feasibility Studies 2024 10:13
  31. Complications after radical cystectomy for urinary bladder cancer are common. Physical activity after surgery is thought to reduce complications. However, patients with urinary bladder cancer have low levels o...

    Authors: Andrea Porserud, Patrik Karlsson, Malin Nygren-Bonnier, Markus Aly and Maria Hagströmer
    Citation: Pilot and Feasibility Studies 2024 10:12
  32. Pediatric brain tumor survivors (PBTS) are at risk of physical, cognitive, and psychosocial challenges related to their diagnosis and treatment. Routine follow-up care as adults is therefore essential to their...

    Authors: Marco Bonanno, Leandra Desjardins, Tziona Lugasi, Julie Carrier, Nathalie Labonté, Serge Sultan, Hallie Coltin, Sébastien Perrault, Carole Provost, Caroline Laverdière, Nancy Cloutier, Andrea Saragosti, Émilie Régnier-Trudeau and Benedicte Koukoui
    Citation: Pilot and Feasibility Studies 2024 10:11
  33. The use of electronic informed consent (eIC) in decentralized trials offers a pragmatic approach to enrolling participants across multiple geographic areas.

    Authors: Amy Corneli, Summer Starling, Yujung Choi, Jurgis Vosylius, Leanne Madre, Andrew Mackinnon and Pamela Tenaerts
    Citation: Pilot and Feasibility Studies 2024 10:10
  34. The management of subacromial shoulder pain represents a significant challenge and is typically managed through either physiotherapy, joint injection or surgical intervention. Recent surgical trials have quest...

    Authors: A. Howard, A. Woods, I. Rombach, J. Achten, D. Appelbe, A. Athwal, E. Jones, K. Draper and S. Gwilym
    Citation: Pilot and Feasibility Studies 2024 10:9
  35. Worldwide, > 1.3 million adults are diagnosed with a gynecologic cancer each year, affecting their wellbeing and quality of life. This manuscript describes the protocol for a study that sought to assess the fe...

    Authors: Jenson Price and Jennifer Brunet
    Citation: Pilot and Feasibility Studies 2024 10:8
  36. Patients evaluated in an emergency department for suspected acute coronary syndromes (ACS; e.g., myocardial infarction) often experience a lingering fear of recurrence, which may adversely affect their mental ...

    Authors: David Lopez-Veneros, Robin Cumella, Ian M. Kronish, Amit Lazarov and Jeffrey L. Birk
    Citation: Pilot and Feasibility Studies 2024 10:7
  37. Indigenous children in colonised nations experience high rates of health disparities linked to historical trauma resulting from displacement and dispossession, as well as ongoing systemic racism. Skin infectio...

    Authors: Bernadette M. Ricciardo, Heather-Lynn Kessaris, Noel Nannup, Dale Tilbrook, Brad Farrant, Carol Michie, Lorraine Hansen, Richelle Douglas, Jacinta Walton, Ainslie Poore, Alexandra Whelan, Timothy C. Barnett, Prasad S. Kumarasinghe, Jonathan R. Carapetis and Asha C. Bowen
    Citation: Pilot and Feasibility Studies 2024 10:6
  38. Using rewards may be an effective method to positively influence children’s eating behaviour but evidence to date is limited, particularly in older children. The cashless canteen systems in schools provides a ...

    Authors: Sarah E. Moore, Ciara Rooney, Charlotte E. Neville, Ryan McConville, Frank Kee, Claire T. McEvoy, Jayne V. Woodside, Judith Hanvey and Michelle C. McKinley
    Citation: Pilot and Feasibility Studies 2024 10:4
  39. Extremity fractures are common, and most are managed operatively; however, despite successful reduction, up to half of patients report persistent post-surgical pain. Furthermore, psychological factors such as ...

    Authors: Kyle Gouveia, Sheila Sprague, Jodi Gallant, Gina Del Fabbro, Jordan Leonard, Sofia Bzovsky, Paula McKay and Jason W. Busse
    Citation: Pilot and Feasibility Studies 2024 10:2
  40. Untreated, urgency urinary incontinence (UUI) and overactive bladder (OAB) can precipitate a vicious cycle of decreasing physical activity, social isolation, fear of falling, and falls. Structured behavioral i...

    Authors: Steve R. Fisher, Alejandro Villasante-Tezanos, Lindsay M. Allen, Monique R. Pappadis and Gokhan Kilic
    Citation: Pilot and Feasibility Studies 2024 10:1
  41. Transcranial direct current stimulation (tDCS) of prefrontal cortex regions has been reported to exert therapeutic effects in patients with major depressive disorder (MDD). Due to its beneficial safety profile...

    Authors: Ulrike Kumpf, Harry Ezim, Matthias Stadler, Gerrit Burkhardt, Ulrich Palm, Esther Dechantsreiter and Frank Padberg
    Citation: Pilot and Feasibility Studies 2023 9:197
  42. Down syndrome is the most common genetic cause of intellectual disability, affecting 700–800 babies annually in the UK (Wu J, Morris J, Eur J Hum Genet 21:1016–9, 2013). Children with Down syndrome have diffic...

    Authors: Kelly Burgoyne, Emma Pagnamenta, Kirstie Hartwell and Vesna Stojanovik
    Citation: Pilot and Feasibility Studies 2023 9:196
  43. COVID-19 is a highly contagious disease where isolation of infected individuals is deemed warranted. If possible, home isolation is preferred over hospitalization. This implies a need for methods of observatio...

    Authors: Hans Joakim Myklebust-Hansen, Eivind Hasvik, Volker M. Solyga and Waleed Ghanima
    Citation: Pilot and Feasibility Studies 2023 9:195
  44. Acquired brain injury (ABI) can lead to biopsychosocial changes such as depression, low self-esteem and fatigue. These changes can cause, and be caused by, sexual issues affecting relationships and wellbeing. ...

    Authors: Hayley Wright, Aimee Walker-Clarke, Avril Drummond, Lisa Kidd, Giles Yeates, Deborah Williams, David McWilliams, Wendy Clyne, Cain C. T. Clark, Peter Kimani and Andy Turner
    Citation: Pilot and Feasibility Studies 2023 9:194
  45. Child criminal exploitation is a form of child abuse that poses a serious risk to the welfare, safety, and wellbeing of young people. Multisystemic therapy (MST) is an intensive family and community-based inte...

    Authors: N. K. Hayden, S. Flynn, F. Blumenfeld, R. P. Hastings, K. M. Gray, S. Cullen, M. A. Cullen and P. E. Langdon
    Citation: Pilot and Feasibility Studies 2023 9:193
  46. Despite family carepartners of individuals post-stroke experiencing high levels of strain and reduced quality of life, stroke rehabilitation interventions rarely address carepartner well-being or offer trainin...

    Authors: Sarah Blanton, George Cotsonis, Kayla Brennan, Robert Song, Laura Zajac-Cox, Sarah Caston, Heather Stewart, Arun Jayaraman, Darcy Reisman, Patricia C. Clark and Trisha Kesar
    Citation: Pilot and Feasibility Studies 2023 9:192
  47. Social connection and loneliness in adolescence are increasingly understood as critical influences on adult mental and physical health. The unique impact of the social isolation imposed by the COVID-19 lockdow...

    Authors: Kain Kim, Andrew Jergel, Shasha Bai, Kolbi Bradley, Brianna Karim, Amit Shah, Shakira Suglia, Ngozi Ugboh and Holly C. Gooding
    Citation: Pilot and Feasibility Studies 2023 9:191

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