Skip to main content

Improving the health-related quality of life of adult Nigerians living with cancer and their family caregivers: intervention development



Evidence for the effectiveness of interventions aimed at improving the health-related quality of life of people living with cancer and/or family members is compelling. However, most interventional research has been conducted in high-income countries, and no intervention had been tested in low-income countries such as Nigeria. It is critical to design a culturally theory-based intervention in a resource-poor setting to address the needs and support coping strategies of cancer patients and their family caregivers.


Theory, evidence, and practical issues were considered. The Medical Research Council framework for developing and evaluating complex interventions and Behaviour Change Wheel provided the framework for intervention design. Findings generated by a needs assessment of adult Nigerians with cancer and their family caregivers and relevant theories (the Spirituality and the Supportive Care Framework for Cancer) informed content development.


A theory-based, culturally tailored socio-spiritual intervention was developed to address the specific needs of adult Nigerians with cancer and their family caregivers. A 4-week intervention included strategies designed to improve social and spiritual support, information and health literacy, and health-related quality of life.


A systemic approach was used to conceptualise an evidence-based and theory-informed intervention tailored to address previously identified shortfalls in support available to adults living with cancer and their family caregivers, in Nigeria. If implemented and effective, such an intervention has the potential to improve the health-related quality of life of people living with cancer and their families in Nigeria.

Peer Review reports


Cancer is a critical public health concern in low- and middle-income countries (LMICs) due to rising obesity rates, increasingly sedentary lifestyles, dietary influences, excessive tobacco and alcohol use, and recurrent carcinogenic infections such as Helicobacter pylori, hepatitis B virus, and human papillomavirus [1]. The global cancer burden, morbidity, and mortality are disproportionately higher in LMICs than in high-income countries (HICs), accounting for approximately 70 to 81% of cancer deaths [2, 3].

In Nigeria, an estimated 72,000 cancer deaths occur each year, with 102,000 new cases diagnosed among its 200 million people [4]. The rising burden of cancer in Nigeria places additional strain on already overtaxed healthcare systems and limited economic infrastructure [4]. Cancer diagnosis has been associated with significant psychological distress, as most patients are frequently unprepared to deal with the initial emotional stress caused by the diagnosis [5]. As treatment advances, the patient is confronted with a variety of emotional, spiritual, social, psychological, and physical challenges related to the disease itself, its perceptions, treatment, and caregiving [6, 7]. The prevailing view in Nigeria is that cancer is a death sentence, and many patients believe they have only a slim chance of life [8].

Psychosocial support programmes have predominantly been conducted in HICs [9, 10], with few published studies on the subject from Africa. For example, our systematic review investigating the characteristics and effectiveness of psychosocial interventions on quality of life of adult people with cancer and their family caregivers identified no studies conducted in Africa [11]. Existing interventions may not be applicable to Nigeria for a variety of reasons, including a lack of consideration to spirituality and culture, which are important to people in Nigeria. Little is known about applying interventions in Nigeria where the cancer/caregiving burden is high and demand for resources is great.

In addressing these gaps, it is crucial to design an intervention that integrates information, social, spiritual, and cultural beliefs. Therefore, this study aimed to design an evidence-based intervention to address the needs and improve the health-related quality of life (HRQoL) of adults living with cancer and their families in resource-poor settings such as Nigeria.

Theoretical framework underpinning the intervention design

This research has been informed by the “gold standard” Medical Research Council (MRC) framework for developing and evaluating complex interventions [12], the most widely used framework in health science [13,14,15,16]. The framework recommends beginning with a review of available evidence, followed by a theory phase, and finally a modelling phase [17]. Craig, Dieppe [18] recommended that researchers do a systematic review of the available evidence on the subject, even if a recent optimistic quality review had been conducted. The theory phase entails analyses using theoretical frameworks to develop and model the intervention. The modelling stage involves hypothesising on what should be targeted (determinants of behaviour) and how this can be achieved (via behaviour change techniques) [19].

We employed the Behaviour Change Wheel (BCW) [20, 21], which facilitates application of behavioural change theory and has been shown to be extremely effective in developing interventions in order to understand and define target behaviours, identify behaviour change techniques, and specify the intervention strategy and its implementation. The BCW is a systematic guide based on three components: capability, opportunity, and motivation behaviour (COM-B) built around, all of which are necessary to generate or change a behaviour [20] (see Fig. 1). According to COM-B, for any behaviour of an individual, or group to occur, there must be the following: [1] capacity to perform the behaviour, which can be physical or psychological [2]; the opportunity for the behaviour to occur, which can be physical, for example environmental factors that allow or promote behaviour, such as time, resources, stimuli, or social (e.g. opportunity afforded by interpersonal influences, social cues, and cultural norms); and [3] motivation to perform the behaviour at the relevant time, which can be reflective (e.g. requiring self-aware planning and evaluation) or automatic (e.g. processes involving wants, needs, desires, impulses, and reflex responses) [20,21,22].

Fig. 1
figure 1

The Behaviour Change Wheel framework

The BCW has nine intervention functions and seven policy-level strategies used to link influences on behaviour, identified by the COM-B, to potential intervention functions and policy categories.


Development of the theory-based, culturally tailored intervention for adult Nigerians living with cancer and their family caregivers consisted of five phases, which are broadly categorised into 3 stages (see Fig. 2).

Fig. 2
figure 2

Intervention design process. MRC, Medical Research Council; BCW, Behaviour Change Wheel

The five phases are as follows:

  1. 1.

    A review of literature to establish the characteristics of psychosocial interventions for people living with cancer and their family caregivers. This is detailed in stage 1 of the MRC framework.

  2. 2.

    Assessment of needs and HRQoL of adult Nigerians living with cancer and their family caregivers. It is described in stage 1 of the MRC Framework.

  3. 3.

    Theoretical framework selection and application are covered in stage 2 of the MRC framework.

  4. 4.

    Operationalising findings into intervention components. This is detailed in the MRC framework stage 2.

  5. 5.

    Process and outcome modelling are outlined in stage 3 of the MRC framework.

The methods and results of phases 1 and 2 have been published elsewhere [11, 23]; hence, they are only briefly summarised below.

MRC framework stage 1 — identifying the evidence base

To change behaviour, one must first understand why certain behaviours occur and what must change for the desired behaviour to occur [24]. Thus, we examined the evidence from previous studies to identify important behaviours to inform the primary outcome of behaviour change [25, 26].

Review of literature

The systematic review of the literature aimed to (i) examine the characteristics of the psychosocial interventions and (ii) examine the effectiveness of the psychosocial interventions on HRQoL of people with cancer and their family caregivers (PROSPERO CRD42020144563).

Needs assessment

Adult Nigerians with cancer and their family caregivers who were attending an oncology clinic for cancer management were invited to take part in the needs assessment. The survey looked at physical, psychological, family/social, spiritual, and healthcare staff needs, as well as information, practical support, cancer health literacy, and HRQoL.

MRC framework stage 2 — identify/develop theory

Developing a theoretical underpinning for the intervention

By incorporating theory into the design of behaviour change programmes [27], we can better understand the causal pathways by which an intervention modifies health behaviour. This stage involves identifying relevant theories that provide insight into the mechanisms through which an intervention is likely to influence individual behaviour. Theoretical frameworks, including the Spirituality Framework [28] and the Supportive Care Framework for Cancer [29], were reviewed, while the MRC framework and BCW were selected to guide the intervention development process [12, 20, 30].

Firstly, the BCW process involved defining the problem in behavioural terms and selecting the target population and behaviour. A behavioural diagnosis was conducted, which included findings from the needs assessment and the theoretical frameworks with COM-B model (see Fig. 3) constructs to determine what strategies should be implemented to support target behaviour performance. Factors identified in the COM-B behavioural diagnosis were further subdivided into 14 theoretical domains according to the Theoretical Domains Framework (TDF) which is recommended as part of the BCW method [20, 30, 31].

Fig. 3
figure 3

Model of Behaviour Change (COM-B). The relationship between capacity, opportunity, motivation, and behaviour

Secondly, elements of the behavioural diagnosis were linked with intervention functions (e.g. education, persuasion, training) likely to influence the target behaviours. For instance, education may be used by interventions to teach cancer parents about coping with cancer trajectory, and training equips them with positive coping skills. APEASE criteria (affordability, practicability, effectiveness/cost-effectiveness, acceptability, safety, and equity) [20] were applied to each intervention function to determine its appropriateness for the needs context.

Finally, the BCT taxonomy [32] was used to identify possible behaviour change techniques that best served the intervention functions. The final stage of the intervention design process was to determine the most effective delivery mode. The selected behaviour change techniques and mode of delivery were translated into intervention components. We conducted a mapping exercise to outline the links between intervention components, intervention functions, Theoretical Domains Framework constructs, and behaviour change techniques. The key findings from each of these BCW steps were synthesised.

MRC framework stage 3 — modelling the process

The first author then organised stakeholder engagement meetings in Nigeria with three oncology nursing experts and five adults with cancer/family caregiver dyads to consider the need assessment findings and intervention material.

Operationalising findings into intervention components

The intervention content and format were developed based on the information gained by the preceding stages (i.e. as reported under the MRC stages 1 and 2 headings).


The results from each stage of the intervention development process are outlined below.

MRC framework stage 1 — identifying the evidence base

According to the findings of the systematic literature review, psychosocial interventions are effective in improving the HRQoL of people living with cancer and their family caregivers [11]. The 12 studies included primarily focused on psychological, physical, and social domains of HRQoL, with spiritual well-being receiving little attention despite its effect on HRQoL. While there is evidence that psychosocial interventions have a significant positive effect on HRQoL, no interventional research aimed at improving HQoL has been conducted in Nigeria among people with cancer and their family caregivers.

We conducted a needs assessment using a cross-sectional descriptive approach with 120 adult Nigerians with cancer and their family caregiver dyads [23]. The findings of the needs survey and systematic literature review produced four evidence statements, which are as follows:

  • Evidence statement 1: The negative impact of cancer diagnosis and caregiving on adult Nigerians with cancer and family caregivers’ HRQoL domains (spiritual, social, physical, and psychological)

  • Evidence statement 2: Cancer information/health literacy is a central factor in understanding cancer progression and treatment options.

  • Evidence statement 3: Spiritual and social support may improve HRQoL of adults with cancer and their family caregivers.

  • Evidence statement 4: Family caregivers face considerable challenges in relation to the caregiving role added to their primary responsibilities.

MRC framework stage 2 — application of theoretical framework to inform intervention development

Following completion of stage 1 of the BCW process, a comprehensive behavioural diagnosis was conducted using the COM-B model. The exercise identified all six sources of behaviour change on the BCW. Table 1 presents the findings of the COM-B model-guided behavioural diagnosis. This provides evidence statements in relation to physical capacity, psychological capability, physical opportunity, social opportunity, reflective motivation, and automatic motivation that should be considered when developing the intervention to address the needs and improve the HRQoL of adult Nigerians living with cancer and their family caregivers.

Table 1 Behavioural diagnosis using the COM-B model

According to Michie, Van Stralen [33], capability, opportunity, and motivation interact to generate behaviour (see Fig. 3). The ability of a person to perform an activity is described as their psychological and physical capacity [33]. It entails possessing the required skills and knowledge [33]. The cognitive states that energise and guide behaviour are collectively referred to as motivation. It includes habitual processes, emotional responding, and analytical decision-making [33]. Opportunity is defined as all the factors that lie outside the individual that make the behaviour possible or prompt it [33]. In consideration of the four evidence statements and the numerous behaviour diagnoses regarding capability, opportunity, and motivation (see Table 1), two target behaviours capable of influencing other behaviours were identified: [1] involvement in socio-spiritual behaviours to increase HRQoL across the study population and [2] appropriate knowledge of the disease process and caregiving among adults with cancer and family caregivers.

These are supported by the Spirituality Framework and the Supportive Care Framework for Cancer, both of which highlight the importance of spiritual, social, information, psychological, or physical support in improving the HRQoL of cancer patients and their family caregivers [28, 34].

The nine intervention functions to prompt behaviour change were identified from the BCW. The intervention functions were graded according to the APEASE criteria. Two intervention functions (coercion and restriction) were eliminated as they did not meet APEASE criteria. The following seven intervention functions were selected: education, persuasion, incentivisation, environmental restructuring, training, modelling, and enablement. Eight out of the fourteen TDF domains were identified during the analysis as influencing the seven identified behaviours. These eight domains were as follows: skills, knowledge, behavioural regulation, social influences, environmental context and resources, professional/social role and identity, emotion, and reinforcement. Each was a target of the intervention (see Table 2).

Table 2 Analysis of target behaviours impacting positive behaviour using COM-B and TDF

The salient COM-B and TDF constructs were mapped to seven intervention functions and 19 behaviour change techniques included in the intervention (see Table 2). For example, during a supervised breathing exercise, group facilitators could demonstrate breathing techniques and then provide feedback to participants regarding their technique. As such, the supervised breathing exercise was mapped to the behaviour change techniques 4.1 “Instruction on how to perform the behaviour” and 2.2 “Feedback on the behaviour” (as shown in Table 2).

MRC framework stage 3 — stakeholder expert panel findings

The expert panel proposed a number of recommendations to optimise intervention implementation and impact, including the importance of cancer health literacy, as most people living with cancer and their family caregivers may hold one or more cancer myths that impact cancer outcomes. The importance of cultural and religious beliefs was also highlighted. They also argued that content should be written in simple language, free of medical terms that may be unfamiliar to participants. Adults with cancer and their family caregivers advocated for a small, easy-to-read booklet they could take home to reinforce key information and helpful behaviour change. Protocols were also developed to clearly describe how to address issues raised by participants that were outside the scope of the intervention. This included identifying outside support services to which participants could be directed and/or referred. To address this and ensure intervention fidelity, facilitators involved in intervention delivery received online training and ongoing supervision from the first author.

Mode of delivery

The BCW recommends that all alternative forms of intervention delivery are explored before selecting the most appropriate approach for the target behaviour, population group, and setting [20]. A four-module interactive, face-to-face training programme was developed. The selection was based on the evaluation against the APEASE criteria. The training was planned to be conducted in four, 120-min sessions. Intervention materials were developed, alongside training manuals for participants and facilitator manuals. Table 3 summarises the planned content and goals, as well as the behaviour change techniques incorporated into each session. Additional file 1 describes the full content of the training for facilitators.

Table 3 Breakdown of intervention content with BCTs


The systematic approach to the design process led to the development of a novel intervention that is patient/family caregiver-centred, evidenced-based, and theoretically informed.

The behaviour change techniques identified in this study were derived from quantitative data and theoretical sources. The COM-B/TDF model was used to quantitatively analyse sources of behaviour, which was then linked to subsequent intervention functions within the BCW, and, finally, identify the appropriate behaviour change techniques to use when developing a tailored intervention to meet the needs of adult Nigerians living with cancer and their family caregivers.

This study identified physical and psychological capability, social and physical opportunity, and reflective and automatic motivation as key targets for a behaviour change intervention for addressing the needs of the study population. In addition, physical skills, knowledge, behavioural regulation, social/spiritual influences, environmental context and resources, social role and identity, emotion, and reinforcement were important TDF domains that need to be targeted in the intervention. Consequently, seven intervention functions including education, persuasion, incentivisation, training, environmental restructuring, modelling, and enablement were identified as relevant for the intervention (as shown in Table 2). These findings were in accordance with the MedEx IMPACT intervention study by Cantwell, Walsh [35] in which the BCW was used to design a physical activity behaviour change intervention for individuals living with cancer. Cantwell, Walsh [35] selected five intervention functions for their study, whereas the current study identified a broader range of intervention functions because it used the APEASE criteria to determine the most relevant intervention function for the target population.

This study utilised 19 behaviour change techniques identified from this process. Targeting cognitive memory by providing prompts and cues, rewarding successful completion of the target behaviour, and providing information about community misconceptions and the consequences of such misconceptions about cancer are just a few of the strategies that can be used to implement behaviour change techniques.

While the BCW and MRC framework offered structured direction for intervention development, there are significant gaps within this guidance. Firstly, both approaches highlight the importance of theory in developing interventions, but neither offer explicit guidance on how to select and apply appropriate theories especially when selecting behaviour change techniques [36]. To tackle this issue, we had to review potentially relevant theories, which were selected to underpin this intervention. Linking theory and intervention content is challenging and may explain why many interventions are developed without a relevant theory [37]. Further research is required to map constructs derived from theories onto effective intervention content [27]. Researchers should consider both theoretically derived behaviour change techniques and those generated by the target population.

The development of the intervention advances implementation science and intervention design research by providing a detailed account of the intervention development process and clearly outlining how theory has informed and been embedded within an intervention for people with cancer and their family caregivers. The training package is reported to the point where it can be delivered in a feasibility study. Testing the integration of intervention components is a critical part of intervention development, and it is expected that further refinements may be made before piloting and full evaluation of the intervention in a randomised controlled trial.

A major strength of the study is the systematic approach used to develop the socio-spiritual intervention, which allows for a rigorous evaluation of the intervention. Employing an integrative theoretical approach guarantees that all components of the intervention will optimise future benefits for participants. Although the BCW is viewed as strongly optimistic and helpful in guiding intervention development, it is not without limitations. The process was time-consuming, from problem identification to intervention design.


This study demonstrates the evidence and theory used to inform the development of a psychosocial intervention. The MRC framework and BCW processes provided a systematic, pragmatic, methodical, and complementary approach to designing a theory-based intervention to meet the needs of adults living with cancer and their family caregivers in Nigeria. The synthesis of findings from this formative research has resulted in the development of a novel intervention that aims to address the needs of this population in Nigeria. The next phase in this research is to evaluate the feasibility and preliminary effectiveness of the intervention among adult Nigerians living with cancer and their family caregivers.



Capability, opportunity, and motivation-behaviour


Low- and middle-income countries


Health-related quality of life


High-income countries


Medical Research Council


Behaviour Change Wheel


Randomised controlled trial


Affordable, practical, effective/cost-effective, acceptable, safe, and equitable


Behaviour change techniques


Theoretical Domains Framework


  1. Shah K, Peek H. Cancer control in low- and middle-income countries: is it time to consider screening? J Global Oncol. 2019;5(5):1–8.

    CAS  Google Scholar 

  2. List JM, O’Connor JM. How should low-and middle-income countries motivate equity in cancer prevention and control? AMA J Ethics. 2020;22(2):147–55.

    Article  Google Scholar 

  3. Fidler MM, Bray F, Soerjomataram I. The global cancer burden and human development: a review: SAGE Publications; 2018. p. 27–36.

    Google Scholar 

  4. Fatiregun OA, Bakare O, Ayeni S, Oyerinde A, Sowunmi AC, Popoola A, et al. 10-year mortality pattern among cancer patients in Lagos State University Teaching Hospital, Ikeja, Lagos. Front Oncol. 2020;10:573036.

  5. Fatiregun O, Sowunmi AC, Habeebu M, Okediji P, Alabi A, Fatiregun O, et al. Prevalence and correlates of unmet supportive needs of Nigerian patients with cancer. Journal of Global. Oncology. 2019;5(5):1–9.

    Google Scholar 

  6. Wei D, Liu X-Y, Chen Y-Y, Zhou X, Hu H-P. Effectiveness of physical, psychological, social, and spiritual intervention in breast cancer survivors: an integrative review. Asia-Pacific J Oncol Nurs. 2016;3(3):226–32.

    Article  Google Scholar 

  7. Hajian-Tilaki E, Hajian-Tilaki K, Moslemi D, Godazandeh G, Firouzbakht M. Association of social support, spirituality with psychological factors in Iranian breast cancer survivors: an evidence from a cross-sectional study. Nurs Open. 2022;9(2):1173–80.

    Article  Google Scholar 

  8. Adegboyega B, Alabi A, Fadipe B, Ololade KO. The ‘evil arrow’myths and misconceptions of cancer at Lagos University Teaching Hospital, Nigeria. SA J Oncol. 2019;3(1):1–5.

    Google Scholar 

  9. Tan, Lam KFY, Lim HA, Chua SM, Kua EH, Griva K, et al. Post-intervention sustainability of a brief psycho-educational support group intervention for family caregivers of cancer patients. Asia-Pacific Psychiatry. 2018;10(3):e12305.

    Article  Google Scholar 

  10. Badger TA, Segrin C, Sikorskii A, Pasvogel A, Weihs K, Lopez AM, et al. Randomized controlled trial of supportive care interventions to manage psychological distress and symptoms in Latinas with breast cancer and their informal caregivers. Psychol Health. 2019;35(1):87–106.

    Article  Google Scholar 

  11. Gabriel I, Creedy D, Coyne E. A systematic review of psychosocial interventions to improve the quality of life of people with cancer and their family caregivers. Nurs Open. 2020;7(5):1299–312.

    Article  Google Scholar 

  12. Craig P, Anderson, Groves, Dieppe P, Macintyre S, Mitchie S, et al. Developing and evaluating complex interventions: the new medical research council guidance. BMJ. 2008;337(7676):979–83.

  13. Bleijenberg N, de Man-van Ginkel JM, Trappenburg JCA, Ettema RGA, Sino CG, Heim N, et al. Increasing value and reducing waste by optimizing the development of complex interventions: enriching the development phase of the Medical Research Council (MRC) Framework. Int J Nurs Stud. 2018;79:86–93.

    Article  Google Scholar 

  14. Sino C, Bleijenberg N, Ettema R, Trappenburg JCA, Hafsteinsdóttir T, Heim N, et al. Increasing value and reducing waste by optimizing the development of complex interventions: enriching the development phase of the Medical Research Council (MRC) Framework. Int J Nurs. 2018;79:86–93.

    Article  Google Scholar 

  15. Bobrow K, Farmer A, Cishe N, Nwagi N, Namane M, Brennan TP, et al. Using the Medical Research Council framework for development and evaluation of complex interventions in a low resource setting to develop a theory-based treatment support intervention delivered via SMS text message to improve blood pressure control. BMC Health Services Research. 2018;18(1):33.

    Article  Google Scholar 

  16. Masulani-Mwale C, Kauye F, Gladstone M, Mathanga D. Development of a psycho-social intervention for reducing psychological distress among parents of children with intellectual disabilities in Malawi. PloS One. 2019;14(2):e0210855.

    Article  CAS  Google Scholar 

  17. Shahsavari H, Matourypour P, Ghiyasvandian S, Nejad MRG. Medical Research Council framework for development and evaluation of complex interventions: a comprehensive guidance. J Educ Health Promot. 2020;9(1):2277–9531.

    Google Scholar 

  18. Craig P, Dieppe P, Macintyre S, Michie S, Nazareth I, Petticrew M. Developing and evaluating complex interventions: the new medical research council guidance. Int J Nurs Stud. 2013;50(5):587–92.

    Article  Google Scholar 

  19. Campbell NC, Murray E, Darbyshire J, Emery J, Farmer A, Griffiths F, et al. Designing and evaluating complex interventions to improve health care. BMJ. 2007;334(7591):455–9.

    Article  Google Scholar 

  20. Michie S, Atkins L, West R. The behaviour change wheel. A guide to designing interventions 1st ed Great Britain: Silverback Publishing; 2014. p. 1003–10.

    Google Scholar 

  21. Michie S, Van Stralen MM, West R. The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Implementation Sci. 2011;6(1):1–12.

    Article  Google Scholar 

  22. Gould GS, Bar-Zeev Y, Bovill M, Atkins L, Gruppetta M, Clarke MJ, et al. Designing an implementation intervention with the behaviour change wheel for health provider smoking cessation care for Australian Indigenous pregnant women. Implement Sci. 2017;12(1):114.

    Article  Google Scholar 

  23. Gabriel I, Creedy D, Coyne E. Quality of life and associated factors among adults living with cancer and their family caregivers. Nurs Health Sci. 2021;23(2):419–29.

    Article  Google Scholar 

  24. Davis R, Campbell R, Hildon Z, Hobbs L, Michie S. Theories of behaviour and behaviour change across the social and behavioural sciences: a scoping review. Health Psychol Rev. 2015;9(3):323–44.

    Article  Google Scholar 

  25. Cox-Seignoret K, Maharaj RG. Unmet needs of patients with cancer in their last year of life as described by caregivers in a developing world setting: a qualitative study. BMC Palliative Care. 2020;19(1):13.

    Article  Google Scholar 

  26. Ramutumbu NJ, Ramathuba DU, Maputle MS. Unmet psychosocial care needs of the oncology patients in a South African rural setting. J Psychol Africa. 2020;30(1):58–63.

    Article  Google Scholar 

  27. Hagger MS, Weed M. DEBATE: do interventions based on behavioral theory work in the real world? Int J Behav Nutr Phys Act. 2019;16(1):1–10.

    Article  Google Scholar 

  28. Hodge DR. Spirituality: towards a theoretical framework. Social Thought. 2000;19(4):1–20.

    Google Scholar 

  29. Fitch M, Porter H, Page B. Supportive care framework: a foundation for person-centred care Pappin communications Pembroke. 2008;18(1):6–14

  30. Cane J, O’Connor D, Michie S. Validation of the theoretical domains framework for use in behaviour change and implementation research. Implement Sci. 2012;7(1):1–17.

    Article  Google Scholar 

  31. French SD, Green SE, O'Connor DA, McKenzie JE, Francis JJ, Michie S, et al. Developing theory-informed behaviour change interventions to implement evidence into practice: a systematic approach using the Theoretical Domains Framework. Implement Sci. 2012;7(1):38.

    Article  Google Scholar 

  32. Michie S, Richardson M, Johnston M, Abraham C, Francis J, Hardeman W, et al. The behavior change technique taxonomy (v1) of 93 hierarchically clustered techniques: building an international consensus for the reporting of behavior change interventions. Ann Behav Med. 2013;46(1):81–95.

    Article  Google Scholar 

  33. Michie VS, MM, West R. The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Implement Sci. 2011;6(1):1–12.

    Article  Google Scholar 

  34. Fitch. Supportive care framework. Can Oncol Nurs J. 2008;18(1):6–24.

    Article  Google Scholar 

  35. Cantwell M, Walsh DM, Furlong B, Moyna N, McCaffrey N, Woods C. The development of the MedEx IMPACT intervention: a patient-centered, evidenced-based and theoretically-informed physical activity behavior change intervention for individuals living with and beyond cancer. Cancer Control. 2020;27(3):1073274820906124.

    Article  Google Scholar 

  36. De Silva MJ, Breuer E, Lee L, Asher L, Chowdhary N, Lund C, et al. Theory of change: A theory-driven approach to enhance the Medical Research Council's framework for complex interventions. Trials. 2014;15(1):1–13.

    Article  Google Scholar 

  37. Prestwich A, Webb TL, Conner M. Using theory to develop and test interventions to promote changes in health behaviour: evidence, issues, and recommendations. Curr Opin Psychol. 2015;5:1–5.

    Article  Google Scholar 

Download references


Not applicable


None. The first author is supported by a Griffith University International Postgraduate Research Scholarship.

Availability of data and materials

This article does not account for data sharing since no datasets were generated or analysed during the study.

Author information

Authors and Affiliations



Study design, IG, DKC, and EC. Manuscript writing and revisions for important intellectual content, IG, DKC, EC, and AM. The authors read and approved the final manuscript.

Corresponding author

Correspondence to Israel Gabriel.

Ethics declarations

Ethics approval and consent to participate

This article contains no human participant. Therefore, ethics is not applicable.

Consent for publication

All authors have given their permission for this manuscript to be published.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gabriel, I., Creedy, D., McGuire, A. et al. Improving the health-related quality of life of adult Nigerians living with cancer and their family caregivers: intervention development. Pilot Feasibility Stud 8, 151 (2022).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: