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  1. Compared to the rest of Europe, the UK has relatively poor cancer outcomes, with late diagnosis and a slow referral process being major contributors. General practitioners (GPs) are often faced with patients p...

    Authors: Stefanie Disbeschl, Alun Surgey, Jessica L. Roberts, Annie Hendry, Ruth Lewis, Nia Goulden, Zoe Hoare, Nefyn Williams, Bethany Fern Anthony, Rhiannon Tudor Edwards, Rebecca-Jane Law, Julia Hiscock, Andrew Carson-Stevens, Richard D. Neal and Clare Wilkinson

    Citation: Pilot and Feasibility Studies 2021 7:100

    Content type: Study Protocol

    Published on:

  2. Fatigue interference with activities, mood, and cognition is one of the most prevalent and bothersome concerns of advanced gastrointestinal (GI) cancer patients. As fatigue interferes with patient functioning,...

    Authors: Catherine E. Mosher, Ekin Secinti, Kurt Kroenke, Paul R. Helft, Anita A. Turk, Patrick J. Loehrer Sr, Amikar Sehdev, Ahmad A. Al-Hader, Victoria L. Champion and Shelley A. Johns

    Citation: Pilot and Feasibility Studies 2021 7:99

    Content type: Study Protocol

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  3. Cervical cancer is the leading cause of cancer incidence and mortality among Malawian women, despite being a largely preventable disease. Implementing a cervical cancer screening and preventive treatment (CCSP...

    Authors: Jennifer H. Tang, Jennifer S. Smith, Shannon McGue, Luis Gadama, Victor Mwapasa, Effie Chipeta, Jobiba Chinkhumba, Erik Schouten, Bagrey Ngwira, Ruanne Barnabas, Mitch Matoga, Maganizo Chagomerana and Lameck Chinula

    Citation: Pilot and Feasibility Studies 2021 7:98

    Content type: Study Protocol

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  4. Given the high risk of infectious mortality among children with severe acute malnutrition (SAM), the World Health Organization recommends routine administration of a broad-spectrum antibiotic like amoxicillin ...

    Authors: Kieran S. O’Brien, Ali Sié, Clarisse Dah, Millogo Ourohire, Ahmed M. Arzika, Valentin Boudo, Elodie Lebas, William W. Godwin, Benjamin F. Arnold and Catherine E. Oldenburg

    Citation: Pilot and Feasibility Studies 2021 7:97

    Content type: Study Protocol

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  5. Pilot and feasibility studies (PAFS) often have complex objectives aimed at assessing feasibility of conducting a larger study. These may not be clear to participants in pilot studies.

    Authors: Mohammed I.U. Khan, Lawrence Mbuagbaw, Matthew Holek, Faris Bdair, Zoha H. Durrani, Katie Mellor, Saskia Eddy, Sandra M. Eldridge, Claire L. Chan, Michael J. Campbell, Christine M. Bond, Sally Hopewell, Gillian A. Lancaster and Lehana Thabane

    Citation: Pilot and Feasibility Studies 2021 7:96

    Content type: Research

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  6. Chronic pain is a poorly managed symptom of inflammatory bowel disease (IBD). Cognitive behavioural therapy (CBT) has an evidence base in functional gastrointestinal conditions and chronic pain. This study aim...

    Authors: Louise Sweeney, Rona Moss-Morris, Wladyslawa Czuber-Dochan and Christine Norton

    Citation: Pilot and Feasibility Studies 2021 7:95

    Content type: Research

    Published on:

  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Laura Williams, Charlotte L. Hall, Susan Brown, Boliang Guo, Marilyn James, Matilde Franceschini, Julie Clarke, Kim Selby, Hena Vijayan, Neeta Kulkarni, Nikki Brown, Kapil Sayal, Chris Hollis and Madeleine J. Groom

    Citation: Pilot and Feasibility Studies 2021 7:94

    Content type: Correction

    Published on:

    The original article was published in Pilot and Feasibility Studies 2021 7:68

  8. Segmental tibial fractures are fractures in two or more areas of the tibial diaphysis resulting in a separate intercalary segment of the bone. Surgical fixation is recommended for patients with segmental tibia...

    Authors: Caroline B. Hing, Elizabeth Tutton, Toby O. Smith, Molly Glaze, Jamie R. Stokes, Jonathan Cook, Melina Dritsaki, Emma Phelps, Cushla Cooper, Alex Trompeter, Michael Pearse, Michael Law and Matthew L. Costa

    Citation: Pilot and Feasibility Studies 2021 7:93

    Content type: Research

    Published on:

  9. Plantar heel pain (PHP) is common and impacts negatively on physical function and quality of life. Initial treatment usually comprises analgesia and self-management advice (SMA), with referral to a physiothera...

    Authors: Linda S. Chesterton, Martin J. Thomas, Gordon Hendry, Ying Chen, David Goddin, Nicola Halliday, Sarah A. Lawton, Martyn Lewis, Christian D. Mallen, Hylton B. Menz, Nadine E. Foster and Edward Roddy

    Citation: Pilot and Feasibility Studies 2021 7:92

    Content type: Research

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  10. A feasibility study was conducted to implement the Talk, Instruct, Practice, Plan and Support (TIPPS) intervention for pregnant women to enhance infant birth weight in a conflict area in Low- and Middle-Income Co...

    Authors: Lamis Abuhaloob, Nahla Helles, Peter Mossey and Ruth Freeman

    Citation: Pilot and Feasibility Studies 2021 7:91

    Content type: Research

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  11. Intensive care unit (ICU) survivors often suffer from cognitive, physical and mental impairments, known as post-intensive care syndrome (PICS). ICU follow-up clinics may improve aftercare of these patients. Th...

    Authors: M. Rohr, S. Brandstetter, C. Bernardi, C. Fisser, K. P. Drewitz, V. Brunnthaler, K. Schmidt, M. V. Malfertheiner and C. J. Apfelbacher

    Citation: Pilot and Feasibility Studies 2021 7:90

    Content type: Study Protocol

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  12. Collaborative decision-making is an innovative decision-making approach that assigns equal power and responsibility to patients and providers. Most veterans with serious mental illnesses like schizophrenia wan...

    Authors: Emily B. H. Treichler, Borsika A. Rabin, William D. Spaulding, Michael L. Thomas, Michelle P. Salyers, Eric L. Granholm, Amy N. Cohen and Gregory A. Light

    Citation: Pilot and Feasibility Studies 2021 7:89

    Content type: Study Protocol

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  13. Contamination occurs when participants allocated to trial control arms receive elements of the active intervention. Randomisation at cluster level, rather than individual level, may reduce or eliminate contami...

    Authors: Elizabeth Stamp, Holly Schofield, Victoria Laurina Roberts, Wendy Burton, Michelle Collinson, June Stevens, Amanda Farrin, Harry Rutter and Maria Bryant

    Citation: Pilot and Feasibility Studies 2021 7:88

    Content type: Methodology

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  14. Diabetic neuropathy dramatically affects musculoskeletal structure and function of the lower limbs by impairing their muscle strength and mobility. Specific muscle strengthening through physiotherapy strategie...

    Authors: Ronaldo H. Cruvinel Júnior, Jane S. S. P. Ferreira, Raquel I. Beteli, Érica Q. Silva, Jady L. Veríssimo, Renan L. Monteiro, Eneida Y. Suda and Isabel C. N. Sacco

    Citation: Pilot and Feasibility Studies 2021 7:87

    Content type: Research

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  15. The health of a woman before conception not only influences the outcome of her pregnancy but also the lifelong health of mother and child. Many women in the UK are inadequately prepared for pregnancy, with rep...

    Authors: Angela C. Flynn, Emma Pryke, Monal Wadhera, Lucilla Poston and Sara L. White

    Citation: Pilot and Feasibility Studies 2021 7:86

    Content type: Study Protocol

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  16. Heart failure affects 26 million people globally, and the optimal management of medicines is crucial for patients, particularly when their care is transferred between hospital and the community. Optimising cli...

    Authors: Beth Fylan, Hanif Ismail, Suzanne Hartley, Chris P. Gale, Amanda J. Farrin, Peter Gardner, Jonathan Silcock and David P. Alldred

    Citation: Pilot and Feasibility Studies 2021 7:85

    Content type: Research

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  17. Stress can negatively impact an individual’s health and well-being and high levels of stress are noted to exist among college students today. While traditional treatment methods are plagued with stigma and tra...

    Authors: Brenna Lin, Christopher Prickett and Steven Woltering

    Citation: Pilot and Feasibility Studies 2021 7:84

    Content type: Research

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  18. Voiding dysfunction (VD) is a common neurogenic lower urinary tract dysfunction (NLUTD) in multiple sclerosis (MS) patients. Currently, the only effective management for VD and urinary retention in MS patients...

    Authors: Khue Tran, Zhaoyue Shi, Christof Karmonik, Blessy John, Hamida Rajab, Santosh A. Helekar, Timothy Boone and Rose Khavari

    Citation: Pilot and Feasibility Studies 2021 7:83

    Content type: Study Protocol

    Published on:

  19. Preliminary research suggests that a mindfulness-based treatment approach may be beneficial for adults with tic disorders. In the present study, we report on the feasibility, acceptability, safety, and symptom...

    Authors: Hannah E. Reese, W. Alan Brown, Berta J. Summers, Jin Shin, Grace Wheeler and Sabine Wilhelm

    Citation: Pilot and Feasibility Studies 2021 7:82

    Content type: Research

    Published on:

  20. ecofit is an evidence-based multi-component physical activity intervention that integrates smartphone technology, the outdoor environment, and social support. In a previous efficacy trial, significant improvement...

    Authors: Magdalena Wilczynska, Anna K. Jansson, David R. Lubans, Jordan J. Smith, Sara L. Robards and Ronald C. Plotnikoff

    Citation: Pilot and Feasibility Studies 2021 7:81

    Content type: Research

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  21. Obstructive sleep apnoea (OSA) is very common in patients with type 2 diabetes (T2D). We and others have shown that OSA was associated with diabetes-related microvascular complications in patients with T2D in ...

    Authors: Christina Antza, Ryan Ottridge, Smitaa Patel, Gemma Slinn, Sarah Tearne, Matthew Nicholls, Brendan Cooper, Asad Ali and Abd A. Tahrani

    Citation: Pilot and Feasibility Studies 2021 7:80

    Content type: Study Protocol

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  22. Crohn's disease (CD) is a principal form of inflammatory bowel disease, affecting approximately 1 in every 650 people in the UK. Vitamin D deficiency is common in approximately 57.7% of CD patients; with anaem...

    Authors: Jane Fletcher, Emma Bedson, Michaela Brown, Martin Hewison, Amelia Swift and Sheldon C. Cooper

    Citation: Pilot and Feasibility Studies 2021 7:79

    Content type: Study Protocol

    Published on:

  23. Prostate cancer predisposes patients and caregivers to a wide range of complex physical and psychosocial challenges, and interventions must incorporate a wide range of self-management strategies to help patien...

    Authors: Sylvie D. Lambert, Lindsay R. Duncan, Janet Ellis, John Wellesley Robinson, Carly Sears, Nicole Culos-Reed, Andrew Matthew, Manon De Raad, Jamie Lynn Schaffler, Daniel Santa Mina, Paramita Saha-Chaudhuri, Helen McTaggart-Cowan and Stuart Peacock

    Citation: Pilot and Feasibility Studies 2021 7:78

    Content type: Study Protocol

    Published on:

  24. The use of multiple medications (polypharmacy) is a concern in older people (≥65 years) and is associated with negative health outcomes. For older populations with multimorbidity, polypharmacy is the reality a...

    Authors: Audrey Rankin, Cathal A. Cadogan, Heather E. Barry, Evie Gardner, Ashley Agus, Gerard J. Molloy, Ashleigh Gorman, Cristín Ryan, Claire Leathem, Marina Maxwell, Gerard J. Gormley, Alan Ferrett, Pat McCarthy, Tom Fahey and Carmel M. Hughes

    Citation: Pilot and Feasibility Studies 2021 7:77

    Content type: Study Protocol

    Published on:

  25. People with type 2 diabetes mellitus (T2DM) generally spend a large amount of time sitting. This increases their risk of cardiovascular disease, premature mortality, diabetes-related complications and mental h...

    Authors: Daniel P. Bailey, Charlotte L. Edwardson, Yannis Pappas, Feng Dong, David J. Hewson, Stuart J. H. Biddle, Marsha L. Brierley and Angel M. Chater

    Citation: Pilot and Feasibility Studies 2021 7:76

    Content type: Study Protocol

    Published on:

  26. The consumption of resistant starches is a promising adjuvant therapy for patients with inflammatory bowel disease. Rigorous evaluation of resistant starches in this setting depends on the intervention being d...

    Authors: Gisell Castillo, David R. Mack, Manoj M. Lalu, Ruth Singleton, Dean A. Fergusson, Alain Stintzi, Megan Harrison and Justin Presseau

    Citation: Pilot and Feasibility Studies 2021 7:75

    Content type: Study Protocol

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  27. Home exposure to secondhand smoke (SHS) is highly prevalent amongst pregnant women in low- and middle-income countries like India and Bangladesh. The literature on the efficacy of behaviour change intervention...

    Authors: Veena A. Satyanarayana, Cath Jackson, Kamran Siddiqi, Prabha S. Chandra, Rumana Huque, Mukesh Dherani, Shammi Nasreen, Pratima Murthy and Atif Rahman

    Citation: Pilot and Feasibility Studies 2021 7:74

    Content type: Research

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  28. Informal caregivers, often family and friends, experience significant psychological and physical distress leading to reductions in health and quality of life (QOL). Mind-body interventions focused on caregiver...

    Authors: Pinky Shani, Kristin Raeesi, Eli Walter, Kai Lewis, Wanyi Wang, Lorenzo Cohen, Gloria Y. Yeh, Cecile A. Lengacher and Peter M. Wayne

    Citation: Pilot and Feasibility Studies 2021 7:73

    Content type: Study protocol

    Published on:

  29. The Odon Device™ is a new device for assisted vaginal birth that employs an air cuff around the fetal head for traction. Assisted vaginal birth (AVB) is a vital health intervention that can result in better ou...

    Authors: Emily J. Hotton, Mary Alvarez, Erik Lenguerrand, Julia Wade, Natalie S. Blencowe, Tim J. Draycott and Joanna F. Crofts

    Citation: Pilot and Feasibility Studies 2021 7:72

    Content type: Study Protocol

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  30. Discharge teaching by nurses during hospitalization is essential to provide multimorbid inpatients with the knowledge and skills to self-manage their health conditions. However, available disease-specific teac...

    Authors: Joanie Pellet, Marianne Weiss, Franziska Zúñiga and Cedric Mabire

    Citation: Pilot and Feasibility Studies 2021 7:71

    Content type: Study Protocol

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  31. Increased physical activity can have health benefits among inactive individuals. In Sweden, the healthcare system uses physical activity on prescription (PAP) to motivate patients to increase their physical ac...

    Authors: Peter Nymberg, Susanna Calling, Emelie Stenman, Karolina Palmér, Eva Ekvall Hansson, Kristina Sundquist, Jan Sundquist and Bengt Zöller

    Citation: Pilot and Feasibility Studies 2021 7:70

    Content type: Research

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  32. Like many low- and middle-income countries, almost half of the proportion of the South African population is under the age of 25. Given the peak age of onset for most mental health problems is in adolescence, ...

    Authors: K. Sorsdahl, C. van der Westhuizen, M. Neuman, H. A. Weiss and B. Myers

    Citation: Pilot and Feasibility Studies 2021 7:69

    Content type: Study Protocol

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  33. Medication for attention deficit hyperactivity disorder (ADHD) should be closely monitored to ensure optimisation. There is growing interest in using computerised assessments of ADHD symptoms to support medica...

    Authors: Laura Williams, Charlotte L. Hall, Susan Brown, Boliang Guo, Marilyn James, Matilde Franceschini, Julie Clarke, Kim Selby, Hena Vijayan, Neeta Kulkarni, Nikki Brown, Kapil Sayal, Chris Hollis and Madeleine J. Groom

    Citation: Pilot and Feasibility Studies 2021 7:68

    Content type: Research

    Published on:

    The Correction to this article has been published in Pilot and Feasibility Studies 2021 7:94

  34. Endometriosis (where endometrial-like tissue is found outside the uterus) affects ~ 176 million women worldwide and can lead to debilitating pelvic pain. There is an unmet need for new medical treatment option...

    Authors: H. W. Leow, M. Koscielniak, L. Williams, P. T. K. Saunders, J. Daniels, A. M. Doust, M-C Jones, G. D. Ferguson, Y. Bagger, A. W. Horne and L. H. R. Whitaker

    Citation: Pilot and Feasibility Studies 2021 7:67

    Content type: Study Protocol

    Published on:

  35. Very premature birth (gestational age between 28 and 31 + 6 weeks) is associated with increased risk of cognitive delay and attention deficit disorder, which have been linked to anomalies in the development of...

    Authors: Oliver Perra, Sam Wass, Alison McNulty, David Sweet, Kostas A. Papageorgiou, Matthew Johnston, Delfina Bilello and Fiona Alderdice

    Citation: Pilot and Feasibility Studies 2021 7:66

    Content type: Research

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  36. Despite pharmacological treatment, many individuals with multiple sclerosis (MS) continue to experience symptoms and medication side effects. Exercise holds promise for MS, but changes in brain structure follo...

    Authors: Chantel D. Mayo, Laureen Harrison, Kristen Attwell-Pope, Lynneth Stuart-Hill and Jodie R. Gawryluk

    Citation: Pilot and Feasibility Studies 2021 7:65

    Content type: Research

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  37. Researchers have begun delivering mindfulness and aerobic exercise training concurrently on the premise that a combination intervention will yield salutary outcomes over and above each intervention alone. An e...

    Authors: Guy A. Prochilo, Ricardo J.S. Costa, Craig Hassed, Richard Chambers and Pascal Molenberghs

    Citation: Pilot and Feasibility Studies 2021 7:64

    Content type: Research

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  38. Hospitalization can be a source of great stress for children and their families. In high-income countries, there are specialized staff to help children cope using different techniques including play. However, ...

    Authors: Muneera A. Rasheed, Vardah Bharuchi, Waliyah Mughis and Ayesha Hussain

    Citation: Pilot and Feasibility Studies 2021 7:63

    Content type: Research

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  39. The outbreak of SARS-CoV-2 (coronavirus, COVID-19), declared a pandemic by the World Health Organization (WHO), is a global health problem with ever-increasing attributed deaths. Vital sign trends are routinel...

    Authors: Fahad Mujtaba Iqbal, Meera Joshi, Gary Davies, Sadia Khan, Hutan Ashrafian and Ara Darzi

    Citation: Pilot and Feasibility Studies 2021 7:62

    Content type: Study Protocol

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  40. Preoperative antiseptic skin solutions are used prior to most surgical procedures; however, there is no definitive research comparing infection-related outcomes following use of the various solutions available...

    Authors: Sheila Sprague, Paige Guyatt, Sofia Bzovsky, Uyen Nguyen, Mohit Bhandari, Lehana Thabane, Brad Petrisor, Herman S. Johal, Jordan Leonard, Shannon Dodds, Franca Mossuto, Robert V. O’Toole, Andrea Howe, Haley K. Demyanovich, Megan Camara, Nathan N. O’Hara…

    Citation: Pilot and Feasibility Studies 2021 7:61

    Content type: Research

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  41. Nurturing care interventions have the potential to promote health and development in early childhood. Amagugu Asakhula was designed to promote developmentally important dietary and movement behaviours among child...

    Authors: Sonja Klingberg, Esther M. F. van Sluijs, Stephanie T. Jong and Catherine E. Draper

    Citation: Pilot and Feasibility Studies 2021 7:60

    Content type: Research

    Published on:

  42. Community-based obesity prevention interventions are often commissioned despite the limited evidence base. HENRY (Health, Exercise, Nutrition for the Really Young) is a programme delivered to parents of presch...

    Authors: Maria Bryant, Michelle Collinson, Wendy Burton, Elizabeth Stamp, Holly Schofield, Bethan Copsey, Suzanne Hartley, Edward Webb and Amanda J. Farrin

    Citation: Pilot and Feasibility Studies 2021 7:59

    Content type: Research

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  43. Activity modification is a key component of patellar tendinopathy treatment but there is a lack of evidence guiding activity modification prescription. Use of activity modification in treatment studies has var...

    Authors: Andrew L. Sprague, Christian Couppé, Ryan T. Pohlig, Lynn Snyder-Mackler and Karin Grävare Silbernagel

    Citation: Pilot and Feasibility Studies 2021 7:58

    Content type: Research

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  44. Given their ubiquity and technological facilities, smartphone-based interventions (SBIs) hold potential to support the cost-effective dissemination of evidence-based treatments for depression. As technological...

    Authors: Christian Aljoscha Lukas and Matthias Berking

    Citation: Pilot and Feasibility Studies 2021 7:57

    Content type: Research

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  45. The optimal analgesia method in video-assisted thoracoscopic surgery (VATS) remains controversial. Intercostal nerve blockade (ICNB) is limited by its duration of action. The erector spinae plane (ESP) block h...

    Authors: Dillon Horth, William Sanh, Peter Moisiuk, Turlough O’Hare, Yaron Shargall, Christian Finley, Waël Hanna, John Agzarian, Mauricio Forero, Kim Davis, Thuva Vanniyasingam, Lehana Thabane and Harsha Shanthanna

    Citation: Pilot and Feasibility Studies 2021 7:56

    Content type: Research

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  46. Allergic diseases are considered to be some of the fastest growing chronic conditions in Africa. Of concern is the paucity of knowledge about the local environment and its role in allergic disease development....

    Authors: Vuyelwa Ndlovu, Moses Chimbari, Elopy Sibanda and Pisirai Ndarukwa

    Citation: Pilot and Feasibility Studies 2021 7:55

    Content type: Research

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  47. The aim of the C-LACE study is to measure cefuroxime concentration in plasma and adipose tissue of non-obese and obese pregnant women undergoing caesarean section.

    Authors: Hanadi H. Alrammaal, Hannah K. Batchelor, Hsu P. Chong, Victoria Hodgetts Morton and R. Katie Morris

    Citation: Pilot and Feasibility Studies 2021 7:54

    Content type: Study Protocol

    Published on:

  48. There is a critical need for an intervention to improve nurses’ eating and physical activity behaviours. As nurses spend a substantial proportion of their waking hours at work, concerted efforts to deliver suc...

    Authors: Brian T. Power, Kirsty Kiezebrink, Julia L. Allan and Marion K. Campbell

    Citation: Pilot and Feasibility Studies 2021 7:53

    Content type: Research

    Published on:

  49. The “A Better everyday LifE” (ABLE) intervention was developed to accommodate the need of a program addressing ability to perform activities of daily living (ADL) in persons with chronic conditions living at h...

    Authors: Kristina Tomra Nielsen, Susanne Guidetti, Cecilie von Bülow, Louise Klokker and Eva Ejlersen Wæhrens

    Citation: Pilot and Feasibility Studies 2021 7:52

    Content type: Research

    Published on:

  50. Admissions to intensive care units (ICUs) are increasing due to an ageing population, and rising incidence of cardiac and respiratory disease. With advances in medical care, more patients are surviving an init...

    Authors: Andrea Rapolthy-Beck, Jennifer Fleming, Merrill Turpin, Kellie Sosnowski, Simone Dullaway and Hayden White

    Citation: Pilot and Feasibility Studies 2021 7:51

    Content type: Study Protocol

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