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  1. Content type: Study Protocol

    An estimated 17,000 patients are treated annually in the UK with radical radiotherapy (RT) for pelvic cancer. New treatment approaches in RT have increased survivorship and changed the subjective toxicity prof...

    Authors: Patricia Holch, Simon Pini, Ann M. Henry, Susan Davidson, Jacki Routledge, Julia Brown, Kate Absolom, Alexandra Gilbert, Kevin Franks, Claire Hulme, Carolyn Morris and Galina Velikova

    Citation: Pilot and Feasibility Studies 2018 4:110

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  2. Content type: Research

    Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in children, and currently, there are no FDA-approved therapies. Plasminogen activator inhibitor-1 (PAI-1) is elevated in children with...

    Authors: Miriam B. Vos, Ran Jin, Juna V. Konomi, Rebecca Cleeton, Jessica Cruz, Saul Karpen, Dellys Soler Rodriguez, Jennifer K. Frediani, Courtney McCracken and Jean Welsh

    Citation: Pilot and Feasibility Studies 2018 4:109

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  3. Content type: Study Protocol

    Worldwide caesarean section (CS) delivery is the most common major operation. Approximately 25% of pregnant women undergo a CS in the UK for delivery of their babies. Sepsis and post-natal infection constitute...

    Authors: V. Hodgetts Morton, A. Wilson, C. Hewitt, A. Weckesser, N. Farmer, D. Lissauer, P. Hardy and R. K. Morris

    Citation: Pilot and Feasibility Studies 2018 4:84

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  4. Content type: Research

    Physical activity (PA) programmes effective under ‘research’ conditions may not be effective under ‘real-world’ conditions. A potential solution is to refer patients to existing PA community-based PA services.

    Authors: Gill Hubbard, Anna Campbell, Abi Fisher, Michelle Harvie, Wendy Maltinsky, Russell Mullen, Elspeth Banks, Jackie Gracey, Trish Gorely, Julie Munro and Gozde Ozakinci

    Citation: Pilot and Feasibility Studies 2018 4:108

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  5. Content type: Research

    Pilot trials are miniature researches carried out with the sole aim of acting as the precursor for larger more definitive studies. Abstracts are used to summarize and introduce the findings to the reading audi...

    Authors: Godsent C. Isiguzo, Moleen Zunza, Maxwell Chirehwa, Bongani M. Mayosi and Lehana Thabane

    Citation: Pilot and Feasibility Studies 2018 4:107

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  6. Content type: Research

    Although supported self-management is a well-recognised part of chronic disease management, it has not been routinely used as part of healthcare for adults with a learning disability. We developed an intervent...

    Authors: Allan House, Gary Latchford, Amy M. Russell, Louise Bryant, Judy Wright, Elizabeth Graham, Alison Stansfield and Ramzi Ajjan

    Citation: Pilot and Feasibility Studies 2018 4:106

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  7. Content type: Review

    Evaluations of complex interventions in public health are frequently undermined by problems that can be identified before the effectiveness study stage. Exploratory studies, often termed pilot and feasibility ...

    Authors: Britt Hallingberg, Ruth Turley, Jeremy Segrott, Daniel Wight, Peter Craig, Laurence Moore, Simon Murphy, Michael Robling, Sharon Anne Simpson and Graham Moore

    Citation: Pilot and Feasibility Studies 2018 4:104

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  8. Content type: Study Protocol

    Sedentary behaviour (sitting) is a highly prevalent negative health behaviour, with individuals of all ages exposed to environments that promote prolonged sitting. Excessive sedentary behaviour adversely affec...

    Authors: Stacy A. Clemes, Daniel D. Bingham, Natalie Pearson, Yu-Ling Chen, Charlotte Edwardson, Rosemary McEachan, Keith Tolfrey, Lorraine Cale, Gerry Richardson, Mike Fray, Stephan Bandelow, Nishal Bhupendra Jaicim, Jo Salmon, David Dunstan and Sally E. Barber

    Citation: Pilot and Feasibility Studies 2018 4:103

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  9. Content type: Study Protocol

    Since the introduction of the Teenage Pregnancy Strategy (TPS), England’s under-18 conception rate has fallen by 55%, but a continued focus on prevention is needed to maintain and accelerate progress. The teen...

    Authors: Ruth Ponsford, Elizabeth Allen, Rona Campbell, Diana Elbourne, Alison Hadley, Maria Lohan, G. J. Melendez-Torres, Catherine H. Mercer, Steve Morris, Honor Young and Chris Bonell

    Citation: Pilot and Feasibility Studies 2018 4:102

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  10. Content type: Research

    Botulinum toxin-A is provided for adults with post-stroke spasticity. Following injection, there is a variation in the rehabilitation therapy type and amount provided. The purpose of this study was to determin...

    Authors: Natasha A. Lannin, Louise Ada, Tamina Levy, Coralie English, Julie Ratcliffe, Doungkamol Sindhusake and Maria Crotty

    Citation: Pilot and Feasibility Studies 2018 4:82

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  11. Content type: Study Protocol

    The HOMEONE study is part of the larger HOME project, which aims to provide evidence of diagnostic and therapeutic yield (“change of management”) of a patient-controlled portable EEG device with dry electrodes fo...

    Authors: Thomas Neumann, Anne Katrin Baum, Ulrike Baum, Renate Deike, Helmut Feistner, Hermann Hinrichs, Joseph Stokes and Bernt-Peter Robra

    Citation: Pilot and Feasibility Studies 2018 4:100

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  12. Content type: Research

    Remote biomonitoring of vital parameters in hospitals and homes has the potential to improve coverage and quality of maternal and neonatal health. Wearable sensors coupled with modern information and communica...

    Authors: Suman Rao, Prashanth Thankachan, Bharadwaj Amrutur, Maryann Washington and Prem K. Mony

    Citation: Pilot and Feasibility Studies 2018 4:99

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  13. Content type: Research

    Pulmonary arterial hypertension (PAH) is an uncommon condition with progressive heart failure and premature death. Treatment costs up to £120,000 per patient per year, and the psychological burden of PAH is su...

    Authors: R. M. R. Tulloh, V. Garratt, J. Tagney, J. Turner-Cobb, E. Marques, R. Greenwood, L. Howard, W. Gin-Sing, A. Barton, P. Ewings, P. Craggs and W. Hollingworth

    Citation: Pilot and Feasibility Studies 2018 4:78

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  14. Content type: Research

    Increasing importance is being placed on optimizing the role of Nursing Aides (NAs) in improving quality of care for nursing home (NH) residents. One approach to do so is to have NAs participate in assessments...

    Authors: Veronique M. Boscart, George Heckman, Meaghan Davey, Michelle Heyer and John P. Hirdes

    Citation: Pilot and Feasibility Studies 2018 4:77

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  15. Content type: Research

    Health economic evaluations rely on the accurate measurement of health service resource use in order to calculate costs. These are usually measured with patient completed questionnaires using instruments such ...

    Authors: Nefyn H. Williams, Kevin Mawdesley, Jessica L. Roberts, Nafees Ud Din, Nicola Totton, Joanna M. Charles, Zoe Hoare and Rhiannon T. Edwards

    Citation: Pilot and Feasibility Studies 2018 4:76

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  16. Content type: Research

    Falls are an emerging public health issue in India, with the impact set to rise as the population ages. We sought to evaluate the acceptability, feasibility and likely impact of a yoga-based program aimed at i...

    Authors: Lisa Keay, Devarsetty Praveen, Abdul Salam, K. V. Rajasekhar, Anne Tiedemann, Vimala Thomas, Jagnoor Jagnoor, Cathie Sherrington and Rebecca Q. Ivers

    Citation: Pilot and Feasibility Studies 2018 4:74

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  17. Content type: Study Protocol

    Endometriosis affects 6–10% of women and is associated with debilitating pelvic pain. It costs the UK > £2.8 billion per year in loss of productivity. Endometriosis can be managed by surgical excision or medic...

    Authors: Ibtisam M. Abokhrais, Philippa T. K. Saunders, Fiona C. Denison, Ann Doust, Linda Williams and Andrew W. Horne

    Citation: Pilot and Feasibility Studies 2018 4:83

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  18. Content type: Research

    A deterioration in mental health and admission to an acute mental health unit can result in skill loss and decreased participation in daily life. Furthermore, discharge from hospital is associated with high ri...

    Authors: Mary Birken, Claire Henderson and Mike Slade

    Citation: Pilot and Feasibility Studies 2018 4:81

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  19. Content type: Research

    The challenges of conducting research with hard to reach vulnerable groups are particularly pertinent for people with learning disabilities. Data collection methods for previous cost and cost-effectiveness ana...

    Authors: John L. O’Dwyer, Amy M. Russell, Louise D. Bryant, Rebecca E. A. Walwyn, Alexandra M. Wright-Hughes, Elizabeth H. Graham, Judy M. Wright, Shaista Meer, Jacqueline Birtwistle, Amanda J. Farrin, Allan O. House and Claire T. Hulme

    Citation: Pilot and Feasibility Studies 2018 4:80

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  20. Content type: Research

    Acute respiratory infections (ARIs), caused by the high level of immaturity of the immune system, are a major cause of morbidity in preterm newborns. The probiotic Escherichia coli strain Nissle 1917 (EcN) is wel...

    Authors: Mykola L. Aryayev, Liudmyla I. Senkivska, Nataliya K. Bredeleva and Irina V. Talashova

    Citation: Pilot and Feasibility Studies 2018 4:79

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  21. Content type: Study Protocol

    Eating disorders are serious psychiatric illnesses that are often associated with poor quality of life and low long-term recovery rates. Peer mentor programs have been found to improve psychiatric symptoms and...

    Authors: Jennifer Beveridge, Andrea Phillipou, Kelly Edwards, Alice Hobday, Krissy Hilton, Cathy Wyett, Anna Saw, Georgia Graham, David Castle, Leah Brennan, Philippa Harrison, Rebecca de Gier, Narelle Warren, Freya Hanly, Benjamin Torrens-Witherow and J. Richard Newton

    Citation: Pilot and Feasibility Studies 2018 4:75

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  22. Content type: Research

    Patellofemoral pain (PFP) is the most common knee condition among adolescents, with a prevalence of 6–7% resulting in reduced function and quality of life. Exercise therapy is recommended for treating PFP, but...

    Authors: Michael S. Rathleff, Camilla R. Rathleff, Sinead Holden, Kristian Thorborg and Jens L. Olesen

    Citation: Pilot and Feasibility Studies 2018 4:73

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  23. Content type: Research

    Efficacy of acupuncture is difficult to demonstrate without a feasible double-blind milieu. Double-blind acupuncture needles have been validated in single session protocols with one or two needles but not been...

    Authors: Judith M. Schlaeger, Nobuari Takakura, Hiroyoshi Yajima, Miho Takayama, Alana D. Steffen, Elizabeth M. Gabzdyl, Robyn A. Nisi, Kathleen McGowan Gruber, Jason M. Bussell and Diana J. Wilkie

    Citation: Pilot and Feasibility Studies 2018 4:72

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  24. Content type: Study Protocol

    Hypertension is the most common modifiable risk factor for cardiovascular disease, with an increasing prevalence with age, but with easily available medications to control it. Adverse effects of these medicati...

    Authors: Marcel Ruzicka, Brendan McCormick, Peter Magner, Tim Ramsay, Cedric Edwards, Ann Bugeja and Swapnil Hiremath

    Citation: Pilot and Feasibility Studies 2018 4:71

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  25. Content type: Research

    Patellofemoral joint (PFJ) osteoarthritis (OA) is prevalent in middle-aged and older adults. Despite this, there are minimal studies which have examined conservative interventions for PFJ OA. Weakness of proxi...

    Authors: Lisa T. Hoglund, Laura Pontiggia and John D. Kelly IV

    Citation: Pilot and Feasibility Studies 2018 4:70

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  26. Content type: Methodology

    Experimentation is a natural part of adolescent maturation. In conjunction with increased exposure to behaviours such as alcohol or substance use, and the potentially intensified influence of peer groups, unhe...

    Authors: Jan Pringle, Lawrence Doi, Divya Jindal-Snape, Ruth Jepson and John McAteer

    Citation: Pilot and Feasibility Studies 2018 4:69

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  27. Content type: Study Protocol

    Parental supervised brushing (PSB) when initiated in infancy can lead to long-term protective home-based oral health habits thereby reducing the risk of dental caries. However, PSB is a complex behaviour with ...

    Authors: Ieva Eskyte, Kara Gray-Burrows, Jenny Owen, Bianca Sykes-Muskett, Tim Zoltie, Susanne Gill, Victoria Smith, Rosemary McEachan, Zoe Marshman, Robert West, Sue Pavitt and Peter Day

    Citation: Pilot and Feasibility Studies 2018 4:68

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  28. Content type: Research

    INVESTIGATE-I (INVasive Evaluation before Surgical Treatment of Incontinence Gives Added Therapeutic Effect?) was a mixed methods study to assess the feasibility of a future randomised controlled trial of inva...

    Authors: Tara Homer, Jing Shen, Luke Vale, Elaine McColl, Douglas G. Tincello and Paul Hilton

    Citation: Pilot and Feasibility Studies 2018 4:67

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  29. Content type: Study Protocol

    The most common physical deficit caused by a stroke is muscle weakness which limits a person’s mobility. Mobility encompasses activities necessary for daily functioning: getting in and out bed, on/off toilet, ...

    Authors: Angie Logan, Jennifer Freeman, Bridie Kent, Jillian Pooler, Siobhan Creanor, Jane Vickery, Doyo Enki, Andrew Barton and Jonathan Marsden

    Citation: Pilot and Feasibility Studies 2018 4:66

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  30. Content type: Research

    Electronic patient-reported outcomes (e-PROs) may provide valid and feasible options for obtaining family input on their child’s functioning for care planning and outcome monitoring, but they have not been ado...

    Authors: Mary A. Khetani, Beth M. McManus, Kristen Arestad, Zachary Richardson, Renee Charlifue-Smith, Cordelia Rosenberg and Briana Rigau

    Citation: Pilot and Feasibility Studies 2018 4:65

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  31. Content type: Study Protocol

    Sepsis is a common condition which kills between 36,000 and 64,000 people every year in the UK. Early recognition and management of sepsis has been shown to reduce mortality and improve the health and well-bei...

    Authors: Chris Moore, Jenna Bulger, Matt Morgan, Timothy Driscoll, Alison Porter, Saiful Islam, Mike Smyth, Gavin Perkins, Bernadette Sewell, Timothy Rainer, Prabath Nanayakkara, Chukwudi Okolie, Susan Allen, Greg Fegan, Jan Davies, Theresa Foster…

    Citation: Pilot and Feasibility Studies 2018 4:64

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  32. Content type: Research

    Condoms remain the main protection against sexually transmitted infections (STIs) when used correctly and consistently. Yet, there are many reported barriers to their use such as negative attitudes, reduced se...

    Authors: Nicole Stone, Cynthia Graham, Sydney Anstee, Katherine Brown, Katie Newby and Roger Ingham

    Citation: Pilot and Feasibility Studies 2018 4:63

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  33. Content type: Research

    Robotic wearable exoskeletons have been utilized as a gait training device in persons with spinal cord injury. This pilot study investigated the feasibility of offering exoskeleton-assisted gait training (EGT)...

    Authors: Shuo-Hsiu Chang, Taimoor Afzal, Jeffrey Berliner and Gerard E. Francisco

    Citation: Pilot and Feasibility Studies 2018 4:62

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  34. Content type: Study Protocol

    Attention deficit hyperactivity disorder (ADHD) is a common and growing problem and a leading cause of child referrals to Child and Adult Mental Health Services (CAMHS). It is a drain on resources across natio...

    Authors: Philippa Fibert, Clare Relton, Tessa Peasgood and David Daley

    Citation: Pilot and Feasibility Studies 2018 4:61

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  35. Content type: Research

    It is important to be able to reliably and feasibly measure infant and toddler physical activity in order to determine adherence to current physical activity guidelines and effects on early life development, g...

    Authors: Alessandra Prioreschi, Thomas Nappey, Kate Westgate, Patrick Olivier, Soren Brage and Lisa Kim Micklesfield

    Citation: Pilot and Feasibility Studies 2018 4:60

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  36. Content type: Study Protocol

    Approximately 1 in 5 Canadians with HIV are unaware of their status. In many provinces and especially rural communities, barriers to HIV testing include lack of access, privacy concerns, and stigma. The availa...

    Authors: Jason Kielly, Deborah V. Kelly, Christine Hughes, Kristine Day, Stephanie Hancock, Shabnam Asghari, Jacqueline Gahagan, Carlo Marra and Hai Nguyen

    Citation: Pilot and Feasibility Studies 2018 4:59

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  37. Content type: Research

    The interest of health care agencies, private payers and policy makers for patient-reported outcomes (PRO) is continuously increasing. There is a substantial need to improve capacity to collect and interpret r...

    Authors: MW. Skinner, C. Chai-Adisaksopha, R. Curtis, N. Frick, M. Nichol, D. Noone, B. O’Mahony, D. Page, J. S. Stonebraker and A. Iorio

    Citation: Pilot and Feasibility Studies 2018 4:58

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  38. Content type: Research

    Depression is very common among stroke survivors with estimated prevalence rates of approximately 33% among stroke survivors, but treatment options are limited. Mindfulness-Based Stress Reduction (MBSR) is an ...

    Authors: Bhautesh Dinesh Jani, Robert Simpson, Maggie Lawrence, Sharon Simpson and Stewart W. Mercer

    Citation: Pilot and Feasibility Studies 2018 4:57

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  39. Content type: Research

    Mood and anxiety disorders have a high lifetime prevalence, and their chronicity adds to the management burden of already scarce and strained mental health care resources, particularly in developing countries....

    Authors: A. S. J. Van der Watt, T. Roos, C. Beyer and S. Seedat

    Citation: Pilot and Feasibility Studies 2018 4:56

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  40. Content type: Study Protocol

    Recent advances in treatment have given patients with chronic kidney disease (CKD) access to safer and more effective medications to treat comorbid hepatitis C virus (HCV) infection. Given the variety and comp...

    Authors: M. C. Politi, N. George, T. Li, K. M. Korenblat, K. J. Fowler, C. Ho, A. Liapakis, D. Roth and J. Yee

    Citation: Pilot and Feasibility Studies 2018 4:55

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  41. Content type: Study Protocol

    Subthalamic nucleus deep brain stimulation (STN-DBS) reduces tremor, muscle stiffness, and bradykinesia in people with Parkinson’s Disease (PD). Walking speed, known to be reduced in PD, typically improves aft...

    Authors: Ryan P. Duncan, Linda R. Van Dillen, Jane M. Garbutt, Gammon M. Earhart and Joel S. Perlmutter

    Citation: Pilot and Feasibility Studies 2018 4:54

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  42. Content type: Research

    While there is a growing interest in the therapeutic benefits of yoga, minority populations with arthritis tend to be under-represented in the research. Additionally, there is an absence of guidance in the lit...

    Authors: Kimberly R. Middleton, Michael M. Ward, Steffany Haaz Moonaz, Miriam Magaña López, Gladys Tataw-Ayuketah, Li Yang, Ana T. Acevedo, Zavera Brandon and Gwenyth R. Wallen

    Citation: Pilot and Feasibility Studies 2018 4:53

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  43. Content type: Study Protocol

    Current guidelines for the provision of protein for critically ill patients are based on incomplete evidence, due to limited data from randomised controlled trials. The present pilot randomised controlled tria...

    Authors: Kate Fetterplace, Adam M. Deane, Audrey Tierney, Lisa Beach, Laura D. Knight, Thomas Rechnitzer, Adrienne Forsyth, Marina Mourtzakis, Jeffrey Presneill and Christopher MacIsaac

    Citation: Pilot and Feasibility Studies 2018 4:52

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  44. Content type: Study Protocol

    Despite family meetings being widely used to facilitate discussion among patients, families, and clinicians in palliative care, there is limited evidence to support their use. This study aims to assess the acc...

    Authors: Philippa J. Cahill, Christine R. Sanderson, Elizabeth A. Lobb and Jane L. Phillips

    Citation: Pilot and Feasibility Studies 2018 4:51

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  45. Content type: Research

    Cancer-related cognitive impairment (CRCI) may negatively affect upwards of 75% of cancer patients. Exercise and cognitive training, independently, may increase functional capacity and aspects of cognitive fun...

    Authors: Brent M. Peterson, Cynthia Johnson, Kaylene R. Case, Daniel Y. K. Shackelford, Jessica M. Brown, Trent L. Lalonde and Reid Hayward

    Citation: Pilot and Feasibility Studies 2018 4:50

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  46. Content type: Study Protocol

    People with dementia progressively lose abilities and are prone to falling. Exercise- and activity-based interventions hold the prospect of increasing abilities, reducing falls, and slowing decline in cognitio...

    Authors: Rowan H. Harwood, Veronika van der Wardt, Sarah E. Goldberg, Fiona Kearney, Pip Logan, Vicky Hood-Moore, Vicky Booth, Jennie E. Hancox, Tahir Masud, Zoe Hoare, Andrew Brand, Rhiannon Tudor Edwards, Carys Jones, Roshan das Nair, Kristian Pollock, Maureen Godfrey…

    Citation: Pilot and Feasibility Studies 2018 4:49

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  47. Content type: Study Protocol

    Rates of participation in Diabetes Prevention Programs (DPPs) are low. This may be due, in part, to low levels of autonomous motivation (i.e., motivation that arises from internal sources and sustains healthy ...

    Authors: Dina H. Griauzde, Jeffrey T. Kullgren, Brad Liestenfeltz, Caroline Richardson and Michele Heisler

    Citation: Pilot and Feasibility Studies 2018 4:48

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  48. Content type: Study Protocol

    Weight management in pregnancy guidelines exist, although dissemination alone is an ineffective means of implementation. Midwives identify the need for support to overcome complex barriers to practice. An eval...

    Authors: Nicola Heslehurst, Judith Rankin, Catherine McParlin, Falko F. Sniehotta, Denise Howel, Stephen Rice and Elaine McColl

    Citation: Pilot and Feasibility Studies 2018 4:47

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  49. Content type: Research

    Medically unexplained loss or alteration of voice—functional dysphonia—is the commonest presentation to speech and language therapists (SLTs). Besides the impact on personal and work life, functional dysphonia...

    Authors: Vincent Deary, Elaine McColl, Paul Carding, Tracy Miller and Janet Wilson

    Citation: Pilot and Feasibility Studies 2018 4:46

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  50. Content type: Study Protocol

    Cognitive impairments, especially deficits of executive function, have been well documented as a core and early feature in Huntington’s disease (HD). Cognitive impairments represent considerable burden and can...

    Authors: Emma Yhnell, Hannah Furby, Rachel S. Breen, Lucy C. Brookes-Howell, Cheney J. G. Drew, Rebecca Playle, Gareth Watson, Claudia Metzler-Baddeley, Anne E. Rosser and Monica E. Busse

    Citation: Pilot and Feasibility Studies 2018 4:45

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