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  1. The physical, occupational, social and psychological impact of chronic leg ulcers (CLUs) on an individual is considerable. Wound-related pain (WRP), the most common symptom, is frequently reported as moderate ...

    Authors: Anne Purcell, Thomas Buckley, Jennie King, Wendy Moyle and Andrea P. Marshall

    Citation: Pilot and Feasibility Studies 2018 4:123

    Content type: Research

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  2. Prescribing for patients taking multiple medicines (i.e. polypharmacy) is challenging for general practitioners (GPs). Limited evidence suggests that the integration of pharmacists into the general practice te...

    Authors: Karen Cardwell, B. Clyne, F. Moriarty, E. Wallace, T. Fahey, F. Boland, L. McCullagh, S. Clarke, K. Finnigan, M. Daly, M. Barry and S. M. Smith

    Citation: Pilot and Feasibility Studies 2018 4:122

    Content type: Study Protocol

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  3. Adolescent depression is common and impairing. There is an urgent need to develop early interventions to prevent depression becoming entrenched. However, current psychological interventions are difficult to ac...

    Authors: Victoria Pile, Patrick Smith, Mary Leamy, Simon E. Blackwell, Richard Meiser-Stedman, Dominic Stringer, Elizabeth G. Ryan, Barnaby D. Dunn, Emily A. Holmes and Jennifer Y. F. Lau

    Citation: Pilot and Feasibility Studies 2018 4:97

    Content type: Study Protocol

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  4. In advanced stages of Parkinson’s disease (PD), patients and neurologists regularly face complex treatment decisions. Shared decision-making (SDM) can support the process where evidence, the clinician’s expert...

    Authors: Frouke A. P. Nijhuis, Glyn Elwyn, Bastiaan R. Bloem, Bart Post and Marjan J. Faber

    Citation: Pilot and Feasibility Studies 2018 4:94

    Content type: Study Protocol

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  5. Platelet-rich plasma (PRP) is a concentrate of autologous blood growth factors which has been shown to provide some symptomatic relief in early osteoarthritis (OA) of the knee. The objective of this study was ...

    Authors: Liam G. Glynn, Alaa Mustafa, Monica Casey, Janusz Krawczyk, Jeanete Blom, Rose Galvin, Ailish Hannigan, Colum P. Dunne, Andrew W. Murphy and Christian Mallen

    Citation: Pilot and Feasibility Studies 2018 4:93

    Content type: Research

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  6. Ovarian cancer is the deadliest gynecologic malignancy and the fifth leading cause of cancer death among women living in the USA. Treatment for ovarian cancer that follows the guidelines published by the Natio...

    Authors: Rachel Pozzar, Laura-Mae Baldwin, Barbara A. Goff and Donna L. Berry

    Citation: Pilot and Feasibility Studies 2018 4:91

    Content type: Research

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  7. The patient-reported outcome measures (PROMs), patient-reported experience measure (PREMs) and Effectiveness Programme (PPEP) launched with the aim of supporting all National Health Service Wales (NHS Wales) o...

    Authors: Susan O’Connell, Robert Palmer, Kathleen Withers, Neeleem Saha, Sarah Puntoni and Grace Carolan-Rees

    Citation: Pilot and Feasibility Studies 2018 4:90

    Content type: Methodology

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  8. Arthritis affects approximately 50 million adults in the USA. Hispanics/Latinos have a higher prevalence of arthritis-attributed activity limitations primarily related to osteoarthritis (OA). Hispanic/Latinos ...

    Authors: Leonor Corsino, Cynthia J. Coffman, Catherine Stanwyck, Eugene Z. Oddone, Hayden B. Bosworth, Ranee Chatterjee, Amy S. Jeffreys, Rowena J. Dolor and Kelli D. Allen

    Citation: Pilot and Feasibility Studies 2018 4:89

    Content type: Research

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  9. Globally, glaucoma is the leading cause of irreversible blindness. However, many patients with glaucoma do not understand their disease which reportedly impacts on their ability to manage their condition succe...

    Authors: H. Waterman, S. Bull, M. Shaw and C. Richardson

    Citation: Pilot and Feasibility Studies 2018 4:121

    Content type: Research

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  10. Randomised controlled trials (RCTs) of complex interventions often begin with a pilot phase to test the proposed methods and refine the intervention before it is trialled. Although the Medical Research Council...

    Authors: Jenna P. Breckenridge, Carla Gianfrancesco, Nicole de Zoysa, Julia Lawton, David Rankin and Elizabeth Coates

    Citation: Pilot and Feasibility Studies 2018 4:120

    Content type: Study Protocol

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  11. Many people living with cardiovascular disease (CVD) are affected by sexual problems associated with the condition. International guidelines recommend all patients with CVD should receive sexual counselling, y...

    Authors: Patrick J. Murphy, Chris Noone, Maureen D’Eath, Dympna Casey, Sally Doherty, Tiny Jaarsma, Andrew W. Murphy, Martin O’Donnell, Noeleen Fallon, Paddy Gillespie, Amirhossein Jalali, Jenny Mc Sharry, John Newell, Elaine Toomey, Elaine E. Steinke and Molly Byrne

    Citation: Pilot and Feasibility Studies 2018 4:88

    Content type: Research

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  12. Follow-up for public health trials may benefit from greater use of routine data. Our trial of a home-visiting intervention for first-time teenage mothers assessed outcomes to the child’s second birthday. To ex...

    Authors: Fiona Lugg-Widger, Rebecca Cannings-John, Lianna Angel, Gwenllian Moody, Jeremy Segrott, Joyce Kenkre and Michael Robling

    Citation: Pilot and Feasibility Studies 2018 4:98

    Content type: Research

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  13. Patients with chronic hepatitis C virus (HCV) experience reduced quality of life, HCV-associated symptoms, comorbid conditions, and treatment side effects. The Cognitive Behavioral Coping Skills group interven...

    Authors: Donna M. Evon, Carol E. Golin, Rachel Ruffin, Shauna Ayres and Michael W. Fried

    Citation: Pilot and Feasibility Studies 2018 4:92

    Content type: Research

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  14. Anorexia nervosa (AN) is a severe psychiatric condition characterized by low body weight, fear of weight gain/becoming fat and/or behavior that interferes with weight gain, and body disturbance. Though there h...

    Authors: C. Alix Timko, Tiffanie J. Goulazian, Kathleen Kara Fitzpatrick and Daniel Rodriguez

    Citation: Pilot and Feasibility Studies 2018 4:87

    Content type: Study Protocol

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  15. In the UK and beyond, public funding is used to commission interventions delivered in public health early years settings aimed at improving health and well-being and reducing inequalities in order to promote s...

    Authors: Maria Bryant, Wendy Burton, Michelle Collinson, Suzanne Hartley, Sandy Tubeuf, Kim Roberts, Annemijn E. C. Sondaal and Amanda J. Farrin

    Citation: Pilot and Feasibility Studies 2018 4:118

    Content type: Study Protocol

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  16. Levels of physical activity decline with age. Some of the most disadvantaged individuals in society, such as those from lower socio-economic position, are also the most inactive. Increasing physical activity l...

    Authors: Mark A. Tully, Conor Cunningham, Margaret E. Cupples, Duane Farrell, Wendy Hardeman, Ruth F. Hunter, Bob Laventure, Suzanne M. McDonough, Joanne Morgan, Marie H. Murphy, Ellen E. A. Simpson, Catrine Tudor-Locke, Ashlene Wright and Frank Kee

    Citation: Pilot and Feasibility Studies 2018 4:117

    Content type: Study Protocol

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  17. Multimorbidity, polypharmacy, and older age predispose seniors to adverse drug events (ADE). Seniors with an ADE experience greater morbidity, mortality, and health care utilization compared to their younger c...

    Authors: Joanne Man-Wai Ho, Jennifer Tung, Janine Maitland, Derelie Mangin, Lehana Thabane, J. Michael Pavlin, Jeffrey Alfonsi, Anne Holbrook, Sharon Straus and Sophiya Benjamin

    Citation: Pilot and Feasibility Studies 2018 4:116

    Content type: Study Protocol

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  18. Maternal mental health conditions are prevalent across the world. For women, the perinatal period is associated with increased rates of depression and anxiety. At the same time, there is widespread documentati...

    Authors: Caprice Knapp, Simone Honikman, Michael Wirsching, Gidah Husni-Pascha and Eva Hänselmann

    Citation: Pilot and Feasibility Studies 2018 4:101

    Content type: Research

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  19. Acute respiratory failure (ARF) is a common and life-threatening medical emergency. Standard prehospital management involves controlled oxygen therapy and disease-specific ancillary treatments. Continuous posi...

    Authors: Gordon W. Fuller, Steve Goodacre, Samuel Keating, Gavin Perkins, Matthew Ward, Andy Rosser, Imogen Gunson, Joshua Miller, Mike Bradburn, Praveen Thokala, Tim Harris, Andrew Carson, Maggie Marsh and Cindy Cooper

    Citation: Pilot and Feasibility Studies 2018 4:86

    Content type: Study Protocol

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  20. One third of women experience intimate partner violence (IPV) in their lifetime. Orthopaedic health care professionals are in a good position to identify women experiencing escalating physical violence and act...

    Authors: Kim Madden

    Citation: Pilot and Feasibility Studies 2018 4:115

    Content type: Study Protocol

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  21. The harmful use of alcohol is a causal factor in more than 200 disease and injury conditions and leads to over 3 million deaths every year worldwide. Relatively few problem alcohol users access treatment due t...

    Authors: Fiona L. Hamilton, Jo Hornby, Jessica Sheringham, Stuart Linke, Charlotte Ashton, Kevin Moore, Fiona Stevenson and Elizabeth Murray

    Citation: Pilot and Feasibility Studies 2018 4:114

    Content type: Research

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  22. State health agencies (SHA) and local health agencies (LHA) face several challenges with the dissemination of local health data using Web-Based Data Query Systems (WDQS). To help guide future research, this st...

    Authors: Manik Ahuja, Robert Aseltine, Nicholas Warren, Susan Reisine, Pam Holtzclaw Williams and Andy Cislo

    Citation: Pilot and Feasibility Studies 2018 4:113

    Content type: Research

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  23. We used various methods for identifying and prioritizing patient-centered outcomes (PCOs) for comparative effectiveness research (CER).

    Authors: Evan Mayo-Wilson, Asieh Golozar, Terrie Cowley, Nicole Fusco, Gillian Gresham, Jennifer Haythornthwaite, Elizabeth Tolbert, Jennifer L. Payne, Lori Rosman, Susan Hutfless, Joseph K. Canner and Kay Dickersin

    Citation: Pilot and Feasibility Studies 2018 4:95

    Content type: Methodology

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  24. Despite medical advances, major surgery remains high risk. Up to 44% of patients experience postoperative complications, which can have huge impacts for patients and the healthcare system. Early recognition of...

    Authors: C. L. Downey, J. Croft, H. Buckley, R. Randell, J. M. Brown and D. G. Jayne

    Citation: Pilot and Feasibility Studies 2018 4:112

    Content type: Study Protocol

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  25. Fatigue is rated as the most distressing side effect of radiotherapy treatment for curable breast cancer. About four in ten women treated experience fatigue, which can last for years after treatment. The impac...

    Authors: N. Courtier, S. Gaze, J. Armes, A. Smith, L. Radley, J. Armytage, M. Simmonds, A. Johnson, T. Gambling and J. Hopkinson

    Citation: Pilot and Feasibility Studies 2018 4:85

    Content type: Study Protocol

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  26. Research estimates that 30% of children under the age of 16 years in the UK live with at least one parent with an alcohol use disorder (AUD). Parental AUDs are associated with adverse childhood experiences and...

    Authors: Ruth McGovern, Elaine Stamp, Mehdi Javanbakht, Elaine McColl, Matthew Hickman and Eileen Kaner

    Citation: Pilot and Feasibility Studies 2018 4:111

    Content type: Study Protocol

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  27. Socially disadvantaged men are at high risk of suffering from alcohol-related harm. Disadvantaged groups are less likely to engage with health promotion. There is a need for interventions that reach large numb...

    Authors: Linda Irvine, Ambrose J. Melson, Brian Williams, Falko F. Sniehotta, Gerry Humphris and Iain K. Crombie

    Citation: Pilot and Feasibility Studies 2018 4:105

    Content type: Methodology

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  28. An estimated 17,000 patients are treated annually in the UK with radical radiotherapy (RT) for pelvic cancer. New treatment approaches in RT have increased survivorship and changed the subjective toxicity prof...

    Authors: Patricia Holch, Simon Pini, Ann M. Henry, Susan Davidson, Jacki Routledge, Julia Brown, Kate Absolom, Alexandra Gilbert, Kevin Franks, Claire Hulme, Carolyn Morris and Galina Velikova

    Citation: Pilot and Feasibility Studies 2018 4:110

    Content type: Study Protocol

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  29. Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in children, and currently, there are no FDA-approved therapies. Plasminogen activator inhibitor-1 (PAI-1) is elevated in children with...

    Authors: Miriam B. Vos, Ran Jin, Juna V. Konomi, Rebecca Cleeton, Jessica Cruz, Saul Karpen, Dellys Soler Rodriguez, Jennifer K. Frediani, Courtney McCracken and Jean Welsh

    Citation: Pilot and Feasibility Studies 2018 4:109

    Content type: Research

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  30. Worldwide caesarean section (CS) delivery is the most common major operation. Approximately 25% of pregnant women undergo a CS in the UK for delivery of their babies. Sepsis and post-natal infection constitute...

    Authors: V. Hodgetts Morton, A. Wilson, C. Hewitt, A. Weckesser, N. Farmer, D. Lissauer, P. Hardy and R. K. Morris

    Citation: Pilot and Feasibility Studies 2018 4:84

    Content type: Study Protocol

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  31. Physical activity (PA) programmes effective under ‘research’ conditions may not be effective under ‘real-world’ conditions. A potential solution is to refer patients to existing PA community-based PA services.

    Authors: Gill Hubbard, Anna Campbell, Abi Fisher, Michelle Harvie, Wendy Maltinsky, Russell Mullen, Elspeth Banks, Jackie Gracey, Trish Gorely, Julie Munro and Gozde Ozakinci

    Citation: Pilot and Feasibility Studies 2018 4:108

    Content type: Research

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  32. Pilot trials are miniature researches carried out with the sole aim of acting as the precursor for larger more definitive studies. Abstracts are used to summarize and introduce the findings to the reading audi...

    Authors: Godsent C. Isiguzo, Moleen Zunza, Maxwell Chirehwa, Bongani M. Mayosi and Lehana Thabane

    Citation: Pilot and Feasibility Studies 2018 4:107

    Content type: Research

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  33. Although supported self-management is a well-recognised part of chronic disease management, it has not been routinely used as part of healthcare for adults with a learning disability. We developed an intervent...

    Authors: Allan House, Gary Latchford, Amy M. Russell, Louise Bryant, Judy Wright, Elizabeth Graham, Alison Stansfield and Ramzi Ajjan

    Citation: Pilot and Feasibility Studies 2018 4:106

    Content type: Research

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  34. Evaluations of complex interventions in public health are frequently undermined by problems that can be identified before the effectiveness study stage. Exploratory studies, often termed pilot and feasibility ...

    Authors: Britt Hallingberg, Ruth Turley, Jeremy Segrott, Daniel Wight, Peter Craig, Laurence Moore, Simon Murphy, Michael Robling, Sharon Anne Simpson and Graham Moore

    Citation: Pilot and Feasibility Studies 2018 4:104

    Content type: Review

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  35. Sedentary behaviour (sitting) is a highly prevalent negative health behaviour, with individuals of all ages exposed to environments that promote prolonged sitting. Excessive sedentary behaviour adversely affec...

    Authors: Stacy A. Clemes, Daniel D. Bingham, Natalie Pearson, Yu-Ling Chen, Charlotte Edwardson, Rosemary McEachan, Keith Tolfrey, Lorraine Cale, Gerry Richardson, Mike Fray, Stephan Bandelow, Nishal Bhupendra Jaicim, Jo Salmon, David Dunstan and Sally E. Barber

    Citation: Pilot and Feasibility Studies 2018 4:103

    Content type: Study Protocol

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  36. Since the introduction of the Teenage Pregnancy Strategy (TPS), England’s under-18 conception rate has fallen by 55%, but a continued focus on prevention is needed to maintain and accelerate progress. The teen...

    Authors: Ruth Ponsford, Elizabeth Allen, Rona Campbell, Diana Elbourne, Alison Hadley, Maria Lohan, G. J. Melendez-Torres, Catherine H. Mercer, Steve Morris, Honor Young and Chris Bonell

    Citation: Pilot and Feasibility Studies 2018 4:102

    Content type: Study Protocol

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  37. Botulinum toxin-A is provided for adults with post-stroke spasticity. Following injection, there is a variation in the rehabilitation therapy type and amount provided. The purpose of this study was to determin...

    Authors: Natasha A. Lannin, Louise Ada, Tamina Levy, Coralie English, Julie Ratcliffe, Doungkamol Sindhusake and Maria Crotty

    Citation: Pilot and Feasibility Studies 2018 4:82

    Content type: Research

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  38. The HOMEONE study is part of the larger HOME project, which aims to provide evidence of diagnostic and therapeutic yield (“change of management”) of a patient-controlled portable EEG device with dry electrodes fo...

    Authors: Thomas Neumann, Anne Katrin Baum, Ulrike Baum, Renate Deike, Helmut Feistner, Hermann Hinrichs, Joseph Stokes and Bernt-Peter Robra

    Citation: Pilot and Feasibility Studies 2018 4:100

    Content type: Study Protocol

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  39. Remote biomonitoring of vital parameters in hospitals and homes has the potential to improve coverage and quality of maternal and neonatal health. Wearable sensors coupled with modern information and communica...

    Authors: Suman Rao, Prashanth Thankachan, Bharadwaj Amrutur, Maryann Washington and Prem K. Mony

    Citation: Pilot and Feasibility Studies 2018 4:99

    Content type: Research

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  40. Pulmonary arterial hypertension (PAH) is an uncommon condition with progressive heart failure and premature death. Treatment costs up to £120,000 per patient per year, and the psychological burden of PAH is su...

    Authors: R. M. R. Tulloh, V. Garratt, J. Tagney, J. Turner-Cobb, E. Marques, R. Greenwood, L. Howard, W. Gin-Sing, A. Barton, P. Ewings, P. Craggs and W. Hollingworth

    Citation: Pilot and Feasibility Studies 2018 4:78

    Content type: Research

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  41. Increasing importance is being placed on optimizing the role of Nursing Aides (NAs) in improving quality of care for nursing home (NH) residents. One approach to do so is to have NAs participate in assessments...

    Authors: Veronique M. Boscart, George Heckman, Meaghan Davey, Michelle Heyer and John P. Hirdes

    Citation: Pilot and Feasibility Studies 2018 4:77

    Content type: Research

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  42. Health economic evaluations rely on the accurate measurement of health service resource use in order to calculate costs. These are usually measured with patient completed questionnaires using instruments such ...

    Authors: Nefyn H. Williams, Kevin Mawdesley, Jessica L. Roberts, Nafees Ud Din, Nicola Totton, Joanna M. Charles, Zoe Hoare and Rhiannon T. Edwards

    Citation: Pilot and Feasibility Studies 2018 4:76

    Content type: Research

    Published on:

  43. Falls are an emerging public health issue in India, with the impact set to rise as the population ages. We sought to evaluate the acceptability, feasibility and likely impact of a yoga-based program aimed at i...

    Authors: Lisa Keay, Devarsetty Praveen, Abdul Salam, K. V. Rajasekhar, Anne Tiedemann, Vimala Thomas, Jagnoor Jagnoor, Cathie Sherrington and Rebecca Q. Ivers

    Citation: Pilot and Feasibility Studies 2018 4:74

    Content type: Research

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  44. Endometriosis affects 6–10% of women and is associated with debilitating pelvic pain. It costs the UK > £2.8 billion per year in loss of productivity. Endometriosis can be managed by surgical excision or medic...

    Authors: Ibtisam M. Abokhrais, Philippa T. K. Saunders, Fiona C. Denison, Ann Doust, Linda Williams and Andrew W. Horne

    Citation: Pilot and Feasibility Studies 2018 4:83

    Content type: Study Protocol

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  45. A deterioration in mental health and admission to an acute mental health unit can result in skill loss and decreased participation in daily life. Furthermore, discharge from hospital is associated with high ri...

    Authors: Mary Birken, Claire Henderson and Mike Slade

    Citation: Pilot and Feasibility Studies 2018 4:81

    Content type: Research

    Published on:

  46. The challenges of conducting research with hard to reach vulnerable groups are particularly pertinent for people with learning disabilities. Data collection methods for previous cost and cost-effectiveness ana...

    Authors: John L. O’Dwyer, Amy M. Russell, Louise D. Bryant, Rebecca E. A. Walwyn, Alexandra M. Wright-Hughes, Elizabeth H. Graham, Judy M. Wright, Shaista Meer, Jacqueline Birtwistle, Amanda J. Farrin, Allan O. House and Claire T. Hulme

    Citation: Pilot and Feasibility Studies 2018 4:80

    Content type: Research

    Published on:

  47. Acute respiratory infections (ARIs), caused by the high level of immaturity of the immune system, are a major cause of morbidity in preterm newborns. The probiotic Escherichia coli strain Nissle 1917 (EcN) is wel...

    Authors: Mykola L. Aryayev, Liudmyla I. Senkivska, Nataliya K. Bredeleva and Irina V. Talashova

    Citation: Pilot and Feasibility Studies 2018 4:79

    Content type: Research

    Published on:

  48. Eating disorders are serious psychiatric illnesses that are often associated with poor quality of life and low long-term recovery rates. Peer mentor programs have been found to improve psychiatric symptoms and...

    Authors: Jennifer Beveridge, Andrea Phillipou, Kelly Edwards, Alice Hobday, Krissy Hilton, Cathy Wyett, Anna Saw, Georgia Graham, David Castle, Leah Brennan, Philippa Harrison, Rebecca de Gier, Narelle Warren, Freya Hanly, Benjamin Torrens-Witherow and J. Richard Newton

    Citation: Pilot and Feasibility Studies 2018 4:75

    Content type: Study Protocol

    Published on:

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