Table 2 Baseline demographic characteristics and admission vitals (subjects 1–29 and 30–50)

Subjects 1–29 patient characteristics

Liberal (n = 14)

Restricted (n = 15)

Total (n = 29)

Female sex

8 (57.1%)

8 (53.3%)

16 (55.2%)

Non-bleeding arm

9 (64.3%)

13 (86.7%)

22 (75.9%)

Age, median (IQR)

10.300 (6.025, 12.775)

13.800 (7.850, 14.500)

11.900 (7.600, 14.100)

Weight in kg, median (IQR)

31.100 (22.425, 42.850)

33.000 (25.650, 52.550)

32.200 (23.700, 46.400)

Height in cm, median (IQR)

137.000 (115.500, 150.250)

132.000 (123.000, 155.000)

135.000 (120.000, 153.000)

Trauma case

3 (21.4%)

0 (0.0%)

3 (10.3%)

Comorbidity

11 (78.6%)

14 (93.3%)

25 (86.2%)

Peds surgery service

5 (35.7%)

5 (33.3%)

10 (34.5%)

Peds urology service

1 (7.1%)

1 (6.7%)

2 (6.9%)

Peds ortho service

7 (50.0%)

10 (66.7%)

17 (58.6%)

Other peds service

1 (7.1%)

1 (6.7%)

2 (6.9%)

Total crystalloid in cc/kg/hr, median (IQR)

2.915 (2.119, 4.148)

2.458 (1.643, 3.612)

2.659 (1.952, 3.804)

Total time on protocol in hrs, median (IQR)

26.950 (12.492, 40.979)

27.833 (15.525, 41.292)

27.000 (11.950, 41.317)

Admission pH, median (IQR)

7.390 (7.310, 7.410)

7.370 (7.330, 7.410)

7.380 (7.312, 7.410)

Admission HCO3, median (IQR)

24.150 (23.350, 25.250)

23.650 (23.025, 24.425)

23.900 (23.200, 24.950)

Admission Lactate, median (IQR)

1.150 (0.825, 1.675)

1.000 (0.700, 1.925)

1.100 (0.775, 1.875)

Admission sodium, median (IQR)

140.000 (140.000, 142.000)

141.500 (140.000, 142.750)

141.000 (140.000, 142.500)

Admission hemoglobin, median (IQR)

9.300 (8.925, 10.200)

10.750 (10.125, 11.250)

10.200 (8.975, 11.025)

Admission creatinine, median (IQR)

0.400 (0.200, 0.420)

0.405 (0.370, 0.595)

0.400 (0.290, 0.545)

Admission white blood cell count, median (IQR)

11.325 (8.575, 14.900)

12.790 (9.117, 17.095)

11.680 (8.723, 15.873)

Admission platelet count, median (IQR)

225.000 (184.250, 267.750)

220.000 (160.250, 293.750)

220.000 (172.250, 279.000)

Admission BUN, median (IQR)

6.000 (5.000, 10.000)

8.500 (8.000, 10.750)

8.000 (6.000, 10.500)

Admission INR, median (IQR)

1.500 (1.400, 1.600)

1.600 (1.350, 1.700)

1.550 (1.375, 1.650)

Admission APTT, median (IQR)

32.600 (30.300, 32.900)

27.350 (25.175, 29.525)

31.700 (28.800, 32.750)

Subjects 30–50 patient characteristics

Liberal (n = 12)

Restricted (n = 9)

Total (n = 21)

Female sex

8 (66.7%)

5 (55.6%)

13 (61.9%)

Non-bleeding arm

10 (83.3%)

8 (88.9%)

18 (85.7%)

Age, median (IQR)

11.700 (10.150, 13.525)

9.900 (5.700, 11.900)

11.500 (8.500, 12.800)

Weight in kg, median (IQR)

35.450 (24.900, 49.175)

28.000 (17.700, 36.700)

28.000 (21.000, 44.700)

Height in cm, median (IQR)

128.000 (100.000, 145.500)

116.000 (109.000, 140.000)

126.000 (100.000, 140.000)

Trauma case

0 (0.0%)

2 (22.2%)

2 (9.5%)

Comorbidity

11 (91.7%)

5 (55.6%)

16 (76.2%)

Peds surgery service

4 (33.3%)

2 (22.2%)

6 (28.6%)

Peds urology service

0 (0%)

0 (0%)

0 (0%)

Peds ortho service

10 (83.3%)

6 (66.7%)

16 (76.2%)

Other peds service

0 (0%)

0 (0%)

0 (0%)

Total crystalloid in cc/kg/h, median (IQR)

2.567 (1.527, 3.095)

1.602 (1.523, 2.434)

2.336 (1.506, 2.893)

Total time on protocol in hrs, median (IQR)

20.183 (12.750, 26.708)

12.000 (6.858, 35.308)

19.600 (7.833, 29.325)

Admission pH, median (IQR)

7.370 (7.330, 7.385)

7.360 (7.320, 7.385)

7.370 (7.330, 7.390)

Admission HCO3, median (IQR)

25.200 (24.150, 26.300)

21.750 (21.075, 25.350)

24.900 (22.200, 26.400)

Admission Lactate, median (IQR)

0.800 (0.800, 1.650)

1.150 (0.650, 1.725)

1.000 (0.800, 1.900)

Admission sodium, median (IQR)

139.500 (139.000, 140.250)

139.000 (136.000, 141.000)

139.000 (138.000, 141.000)

Admission hemoglobin, median (IQR)

10.650 (9.700, 11.850)

10.900 (10.400, 11.500)

10.800 (10.025, 11.550)

Admission creatinine, median (IQR)

0.550 (0.335, 0.610)

0.450 (0.340, 0.600)

0.480 (0.340, 0.600)

Admission white blood cell count, median (IQR)

15.120 (12.915, 17.593)

15.100 (10.763, 23.598)

15.120 (12.578, 20.058)

Admission platelet count, median (IQR)

212.000 (169.250, 242.500)

220.500 (185.500, 254.000)

217.000 (176.250, 250.750)

Admission BUN, median (IQR)

8.000 (7.000, 10.000)

9.000 (7.000, 11.000)

8.000 (7.000, 11.000)

Admission INR, median (IQR)

1.300 (1.300, 1.675)

1.200 (1.200, 1.300)

1.300 (1.200, 1.400)

Admission APTT, median (IQR)

29.800 (29.000, 35.800)

30.550 (29.525, 31.575)

29.800 (28.950, 34.200)