Fig. 2

Pattern separation task. Legend: Participants are shown a series of pictures of everyday objects and asked to determine if the item is “new” in the context of the experiment, “old” (exact repetition of a previously shown item), or “similar” but not exactly the same, termed “lure” trials. Correct identification of the critical lure trials is thought to depend on hippocampal subregion dentate gyrus (DG)/CA3-mediated functions shown to be associated with age-related memory impairment and memory impairment in amnestic mild cognitive impairment [12]