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Table 10 Feasibility questions and the classification of the feasibility sub-questions

From: Team approach to polypharmacy evaluation and reduction: feasibility randomized trial of a structured clinical pathway to reduce polypharmacy

1. To what extent is implementation of TAPER feasible in a primary care setting?

Categories of outcomes

What is the recruitment, refusal, and drop-out rate of participants, pharmacists, and family physicians?

Process

What are the challenges with determining to extent to which participants meet eligibility criteria?

Process

What is the nature of challenges in terms of participants’ understanding of, and ability to respond to, the surveys?

Process

What is the nature of any instances of unblinding?

Process

What is the length of time to complete the surveys?

Resources

How much travel time does the research team do to complete visits?

Resources

What is the nature of data entry/database problems?

Management

What is the nature of any serious adverse events associated with the intervention or study process?

Scientific

What is the variance, potential floor, and ceiling effects for research outcomes?

Scientific

2. Is there any emergent evidence of direction of effect of TAPER compared to usual care on a range of potential outcomes?

Outcomes include number of medications (potential primary outcome for larger randomized controlled trial), medication dose, quality of life, psychological distress, cognition, mobility-related fatigue, nutritional status, level of mobility functioning, sleep quality, patient enablement, grip strength, falls, healthcare utilization, and adverse events