- O2 Saturation < 90% - Respiratory Rate > 30 bpm - Fi O2 > 0.6 - PEEP > 10 cm H2O/ventilator dysynchrony - Any rescue therapies (NO, Prostatcyclin, prone) - Significant antihypertensive medications - MAP (below target, various support measures) - Bradycardia on significant pharmacological support - Tachycardia > 150 bpm - RASS > 2+ - Large open wound/uncontrolled active bleeding |