Chlorhexidine locking device for central line infection prevention in ICU patients: protocol for an open-label pilot and feasibility randomized controlled trial

Table 1 SPIRIT figure detailing enrolment, interventions, and assessment

Timepoint	Study period
	Enrolment	Allocation	Post-allocation					Close-out
	< 72 h post ICU admission (-t₁)	0	t₁	t₂	t₃	t₄	etc.	intervention discontinued (t_x)
Enrolment
Eligibility screen	X
Informed consent	X
Allocation		X
Interventions
Usual care		X	X	X	X	X	X
CHG locking device		X	X	X	X	X	X
Assessments
Baseline variables	X	X
Recruitment rate	X	X
Consent rate	X	X
Initiation of study procedures		X
Protocol adherence			X	X	X	X	X
Comfort level			X	X	X	X	X
Central line colonization			X	X	X	X	X
Bacteremia			X	X	X	X	X
LOS in ICU								X
LOS in hospital								X
ICU mortality at 28 days								X
Hospital mortality at 28 days								X

ISSN: 2055-5784