Prevention of post-cardiac surgery vitamin D deficiency in children with congenital heart disease: a pilot feasibility dose evaluation randomized controlled trial

Table 4 Pre- and post-operative blood and urine calcium measurements

	High dose (n = 21)	Usual care (n = 20)	p value
Hypercalciuria
Enrolment urine calcium to creatinine ratio above age-based threshold, n (%) (n = 6, 6)	0	1	1.0
Intraoperative urine calcium to creatinine ratio above age-based threshold, n (%) (n = 21, 20)	4 (19%)	3 (15%)	0.73
Post-operative day 1 urine calcium to creatinine ratio above age-based threshold, n (%) (n = 18, 20)	1 (4.8%)	2 (10.0%)	0.61
Hypercalcemia
Mid-treatment ionized calcium concentration (mmol/L) (n = 3, 0)^a	1.17 ± 0.08	n/a	n/a
Pre-surgical ionized calcium concentration (mmol/L) (n = 12, 14)	1.18 ± 0.04	1.20 ± 0.09	0.42
Intraoperative ionized calcium concentration (mmol/L) (n = 21, 20)	1.14 ± 0.07	1.14 ± 0.08	0.912
Post-operative ionized calcium
PICU admission (n = 20, 20)	1.19 ± 0.09	1.20 ± 0.08	0.66
POD1 (n = 21, 20)	1.20 ± 0.07	1.18 ± 0.10	0.28
POD3 (n = 8, 13)	1.19 ± 0.07	1.26 ± 0.08	0.04
POD5 (n = 7, 10)	1.18 ± 0.05	1.18 ± 0.07	0.98
Transient (< 24 h) hypercalcemia during PICU admission, n (%)	0 (0%)	2 (10.0%)	0.23

Hypercalcemia was defined as an ionized calcium level > 1.40 mmol/L or > 1.45 mmol/L for patients < 2 months of age. Hypercalciuria was defined previously published age-based thresholds [28]
PICU Pediatric intensive care unit, POD Post-operative day
^aMid-treatment ionized calcium was only checked for children with an expected study drug therapy duration of > 2 months

ISSN: 2055-5784