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Table 4 Pre- and post-operative blood and urine calcium measurements

From: Prevention of post-cardiac surgery vitamin D deficiency in children with congenital heart disease: a pilot feasibility dose evaluation randomized controlled trial

  High dose (n = 21) Usual care (n = 20) p value
Hypercalciuria
 Enrolment urine calcium to creatinine ratio above age-based threshold, n (%) (n = 6, 6) 0 1 1.0
 Intraoperative urine calcium to creatinine ratio above age-based threshold, n (%) (n = 21, 20) 4 (19%) 3 (15%) 0.73
 Post-operative day 1 urine calcium to creatinine ratio above age-based threshold, n (%) (n = 18, 20) 1 (4.8%) 2 (10.0%) 0.61
Hypercalcemia
 Mid-treatment ionized calcium concentration (mmol/L) (n = 3, 0)a 1.17 ± 0.08 n/a n/a
 Pre-surgical ionized calcium concentration (mmol/L) (n = 12, 14) 1.18 ± 0.04 1.20 ± 0.09 0.42
 Intraoperative ionized calcium concentration (mmol/L) (n = 21, 20) 1.14 ± 0.07 1.14 ± 0.08 0.912
Post-operative ionized calcium
 PICU admission (n = 20, 20) 1.19 ± 0.09 1.20 ± 0.08 0.66
 POD1 (n = 21, 20) 1.20 ± 0.07 1.18 ± 0.10 0.28
 POD3 (n = 8, 13) 1.19 ± 0.07 1.26 ± 0.08 0.04
 POD5 (n = 7, 10) 1.18 ± 0.05 1.18 ± 0.07 0.98
Transient (< 24 h) hypercalcemia during PICU admission, n (%) 0 (0%) 2 (10.0%) 0.23
  1. Hypercalcemia was defined as an ionized calcium level > 1.40 mmol/L or > 1.45 mmol/L for patients < 2 months of age. Hypercalciuria was defined previously published age-based thresholds [28]
  2. PICU Pediatric intensive care unit, POD Post-operative day
  3. aMid-treatment ionized calcium was only checked for children with an expected study drug therapy duration of > 2 months