Tranexamic acid and rosuvastatin in patients at risk of cardiovascular events after noncardiac surgery: a pilot of the POISE-3 randomized controlled trial

Table 2 Intraoperative characteristics

Characteristic	TXA (N = 49)	TXA placebo (N = 51)	Rosuvastatin (N = 18)	Rosuvastatin placebo (N = 16)
Type of surgery, n (%)
Major vascular surgery^a	8 (16.3)	7 (13.7)	4 (22.2)	2 (12.5)
Other vascular surgery	5 (10.2)	2 (3.9)	0 (0.0)	1 (6.3)
Thoracic surgery	0 (0.0)	1 (2.0)	0 (0.0)	0 (0.0)
Major orthopedic surgery^b	21 (42.9)	21 (41.2)	9 (50.0)	8 (50.0)
Other orthopedic surgery	3 (6.1)	0 (0.0)	0 (0.0)	1 (6.3)
Urology or gynecology surgery	2 (4.1)	3 (6.0)	1 (5.6)	0 (0.0)
Major general surgery^c	5 (10.2)	6 (11.8)	2 (11.1)	2 (12.5)
Spinal surgery	4 (8.2)	9 (17.6)	2 (11.1)	2 (12.5)
Low-risk surgeries^d	1 (2.0)	2 (3.9)	0 (0.0)	0 (0.0)
Type of anesthesia, n (%)
General	28 (57.1)	29 (56.9)	8 (44.4)	12 (75.0)
Spinal	22 (44.9)	25 (49.0)	11 (61.1)	6 (37.5)
Epidural	6 (12.2)	4 (7.8)	2 (11.1)	2 (12.5)
Plexus/nerve block	0 (0.0)	2 (3.9)	1 (5.6)	0 (0.0)
Sedation	5 (10.2)	4 (7.8)	1 (5.6)	1 (6.3)
Intraoperative administration of non-study topical TXA	22 (44.9)	22 (43.1)	9 (50.0)	9 (56.3)
Mean total dose ± SD, g	3.0 ± 0.0	3.0 ± 0.2	3.0 ± 0.0	3.0 ± 0.0

TXA tranexamic acid, SD standard deviation
^aMajor vascular surgery included thoracic aorta reconstructive vascular surgery, aorto-iliac reconstructive vascular surgery, peripheral vascular reconstruction without aortic cross-clamping, and extracranial cerebrovascular surgery
^bMajor orthopedic surgery included major hip or pelvic surgery, internal fixation of femur, knee arthroplasty, above-knee amputation, and lower leg amputation
^cMajor general surgery included complex visceral resection; partial or total colectomy, or stomach surgery; small bowel resection; and major head and neck resection for non-thyroid tumor
^dLow-risk surgery included any other surgery not included above or any of the following surgeries: parathyroid, thyroid, breast, hernia, local anorectal procedure, oophorectomy, salpingectomy, endometrial ablation, peripheral nerve surgery, ophthalmology, vertebral disc surgery, hand surgery, metatarsal resection, cosmetic surgery, arterio-venous access surgery for dialysis

ISSN: 2055-5784