Table 3 Sensitivity analysis to bias in the relative risk (RR) for re-graft in low-friction relative to standard bedding
Scenario | Scenario parameters | Scenario results | Individual level value of information (£) | Population level value of information (£) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
RR bias | RR | INB (£) | Probability low-friction cost-effective | EVPI | EVPPI bias | EVPPI RR | EVPPI Probability regraft | EVPPI cost regraft | EVPI population | EVPPI RR population | |
1. Face-value (base case) | 1.00 (1.00, 1.00) | 0.57 (0.52, 0.632) | 151 (−142, 814) | 0.71 | 20.29 | NA | 0.00 | 1.66 | 16.06 | 174,675 | – |
2. No bias, high uncertainty | 1.00 (0.47, 1.88) | 0.57 (0.27, 1.08) | 237 (− 171, 1551) | 0.65 | 30.69 | 12.61 | 13.45 | 0.57 | 13.85 | 264,165 | 115,789 |
3. Bias in favour low-friction, high uncertainty | 0.80 (0.29, 1.76) | 0.458 (0.17, 1.02) | 490 (− 186, 2772) | 0.75 | 25.02 | 7.96 | 9.96 | 0.06 | 12.16 | 215,354 | 85,755 |
4. Bias against low-friction, high uncertainty | 1.20 (0.65, 2.03) | 0.69 (0.37, 1.17) | 94 (− 177, 919) | 0.50 | 43.47 | 24.44 | 24.81 | 3.65 | 19.33 | 374,215 | 213,597 |
5. No bias, low uncertainty | 1.00 (0.74, 1.31) | 0.57 (0.42, 0.77) | 166 (−141, 952) | 0.69 | 21.74 | 0.62 | 0.82 | 1.41 | 15.51 | 187,103 | 7075 |
6. Bias in favour of low-friction, low uncertainty | 0.80 (0.55, 1.13) | 0.46 (0.31, 0.66) | 334 (−156, 1581) | 0.80 | 16.80 | 0.04 | 0.04 | 0.23 | 12.70 | 144,581 | 311 |
7. Bias against low-friction, low uncertainty | 1.20 (0.94, 1.51) | 0.69 (0.53, 0.88) | 56 (− 131, 553) | 0.51 | 32.64 | 6.01 | 7.27 | 7.05 | 22.81 | 280,986 | 62,608 |