Table 6 Textbox on lessons learnt from BRE-4-MED proof-of-concept study

• Combination of primary and secondary data is feasible

 ○ Routinely collected data from established Cancer Registries can serve as basis and help reducing redundant data collection for physicians and can be complemented by personal PROMs follow-up information

 ○ Utilizing m-health in incurable cancer patients is in general accepted considering its increasing impact in the future. Adaption regarding patient’s benefit (e.g., m-health as personal diary or basis for doctor-patient-communication) will be required

• Strategies for strengthening patient recruitment

 ○ Identification of eligible patients through interdisciplinary tumor board

 ○ For recruiting dedicated study nurse to improve recruitment rate

 ○ Standardized reminder algorithm (postal and phone) to increase response rate

 ○ Adaption of APP/online questionnaire to allow patient keeping track of her/his own m-health entered data and utilize these data for doctor-patient-communication

 ○ Improving visibility of registry by distribution of information and rationale of the study via self-aid groups or patient leaflets