Table 2 Overview of a priori–defined criteria regarding feasibility of the developed BRE-4-MED concept

Defined feasibility criteria for proof-of-concept study

• Linkage of routine data from established Cancer Registry with patient-reported outcomes: combining secondary and primary data

○ Can patients, who gave their consent to data linkage, be identified in the established Registries?

○ Is data exchange between method center (ICE-B), trusted third parties and Cancer Registries practicable?

• Usage of m-health devices by patients and treating physicians

○ Does the concept (log in, username, completion of questionnaire, and transfer to server/central database) work out?

• Proof of organizational requirements regarding:

○ Transfer of written informed consent to method center (ICE-B) for follow-up procedures

○ Procedures of central follow-up by method center feasible (ICE-B) (postal and phone)

• Acceptance of questionnaires/m-health devices in an incurable cancer collective as well as by clinical staff

○ Usage of m-health device

○ Fill out/return of questionnaire/completeness of documentation (appropriateness and comprehensibility of questions in an incurable cohort)