Fig. 2

MIS416 pharmacodynamic immune response of patients grouped according to change in clinical status. Immune proteins most important for discriminating differential immune responses to MIS416: (IFN-γ (a), MIG (b), MCP-1 (c), MIP-1α (d), IL-6 (e), and IL-10 (f)) were quantified at 24-hour (24 Hr) and 7 days (7 D) post doses (PD) 1–4 and values were compared between the patient groups defined as high responder (HR), medium responder (MR) or low responder (LR) based on their extent of clinical response. The patient ID numbers comprising each responder group are shown in parenthesis. Data shown are the mean values (pg/mL) ±SD. Statistical significance was determined by two-way ANOVA followed by Holm-Sidak’s multiple comparison: *p< 0.05;**p< 0.005; ***p< 0.0001