Immediate tumor resection in patients with locally advanced gastroesophageal adenocarcinoma with nonresponse to chemotherapy after 4 weeks of treatment versus resection after completion of chemotherapy (OPTITREAT trial, DRKS00004668): study protocol for a randomized controlled pilot trial

Table 5 Study visits in the OPTITREAT trial

Documentation	Visit 1	Visit 2	Visit 3	Visit 4	Visit 5	FU	FU	FU	FU	FU	FU	FU
	Screening	Before CTx	4 weeks after CTx	Before surgery	Discharge	3 months	6 months	9 months	12 months	18 months	24 months	30 months
Baseline data, demographics	X
Eligibility criteria	X
Endoscopy		X	X
Clinical response			X
Randomization			X
Quality of life	X			X					X
Information about CTx				X
R0 resection					X
Histopathological response					X
Information about surgery					X
Perioperative morbidity					X	X
Perioperative mortalitiy					X	X
Severe adverse events		X	X	X	X	X
Survival analysis/recurrence						X	X	X	X	X	X	X

ISSN: 2055-5784