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Table 2 Chemotherapy schedules

From: Immediate tumor resection in patients with locally advanced gastroesophageal adenocarcinoma with nonresponse to chemotherapy after 4 weeks of treatment versus resection after completion of chemotherapy (OPTITREAT trial, DRKS00004668): study protocol for a randomized controlled pilot trial

2-week protocols

FLOT

FLO

 Docetaxel 50 mg/m2 1 h d (day)1

 Oxaliplatin 85 mg/m2 2 h d1

 Oxaliplatin 85 mg/m2 2 h d1

 Folic acid 200 mg/m2 2 h d1

 Folic acid 200 mg/m2 2 h d1

 5-Fluorouracil 2600 mg/m2 24 h d1

repeat d 15

 5-Fluorouracil 2600 mg/m2 24 h d1

repeat d 15

3-week protocols

 ECF

ECX

 Epirubicin 50 mg/m2 push d1

 Epirubicin 50 mg/m2 push d1

 Cisplatin 60 mg/m2 2 h d1

 Cisplatin 60 mg/m2 2 h d1

 5-Fluorouracil 200 mg/m2 24 h d1–21

repeat d 22

 Capecitabine 625 mg/m2 2×/d p.o. d1–21

repeat d 22

EOF

EOX

 Epirubicin 50 mg/m2 push d1

 Epirubicin 50 mg/m2 push d1

 Oxaliplatin 130 mg/m2 2 h d1

 Oxaliplatin 130 mg/m2 2 h d1

 5-Fluorouracil 200 mg/m2 24 h d1–21

repeat d 22

 Capecitabine 625 mg/m2 2×/d p.o. d1–21

repeat d 22

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Pilot and Feasibility Studies

ISSN: 2055-5784