Multimodal exercise training to reduce frailty in people with multiple sclerosis: study protocol for a pilot randomized controlled trial

Table 3 The multimodal exercise training program

Exercise components	Duration	Description	Target (frailty domains)^a
1) VR treadmill training	15 min	Treadmill walking with interactive virtual environment	• Slowness • Cognition
2) RT	30 min	Seated leg press, seated knee extensions, seated chest press, seated lat pulldowns	• Muscle weakness • Shrinkage
3) VR treadmill training	15 min	Treadmill walking with interactive virtual environment	• Slowness, cognition • Exhaustion

VR Virtual reality, RT Resistance training
^aThe multimodal exercise program will also inherently target the “inactivity” component of frailty

ISSN: 2055-5784