Multimodal exercise training to reduce frailty in people with multiple sclerosis: study protocol for a pilot randomized controlled trial

Table 2 Primary, secondary, and tertiary study outcomes

Information collected from all participants	T_O	T₁	In	T₂	O
Sociodemographics
Age, gender, marital status, race, height, weight, education, and occupation	✓				D
Frailty status
Fried Frailty Status Assessment	✓				D
Cognitive status
Mini-Cog	✓				D
Comprehensive Frailty Assessment
Evaluative Frailty Index for Physical Activity (EFIP)		✓		✓	P
Fall-risk screening
Physiological Profile Assessment (PPA)		✓		✓	S
Quality of life
Multiple Sclerosis Quality-of-Life questionnaire (MSQoL-54)		✓		✓	S
Blood test
Blood biomarkers		✓			T
Safety and feasibility outcomes
Pain (numeric pain rating scales)		✓	✓	✓	P
Adverse events — defined by the NIH		✓	✓	✓	P
Attrition — defined as the participants withdrawing from the study		✓	✓	✓	P
Attendance to intervention — the proportion of sessions attended		✓	✓	✓	S
Subjective feedback		✓	✓	✓	S

✓Recorded in that session, T_O onsite screening visit, T₁ baseline assessment, T₂ post-intervention assessment. O outcome measures, D Demographics, P Primary, S Secondary, T Tertiary

ISSN: 2055-5784