Table 1 Inclusion and exclusion criteria

In-clinic screening

• Age 40–65 years

• Confirmed MS diagnosis by a neurologist

• EDSS ≤ 6.0

• Fluency in spoken and written English

• The presence of other clinically important neurological conditions including Parkinson’s disease and epilepsy

• Active psychiatric problems

• The presence of unstable cardiovascular conditions, arthritis of the lower limb, acute lower back or lower limb pain, rheumatic and/or severe orthopedic problems that may interfere with resistance training

Onsite screening

• Frailty as defined by the Fried frailty phenotype

• Unable to walk 10 m unassisted

• Severe cognitive impairment (Mini-Cog < 3)