Skip to main content

Table 2 Potential treatment effect of the use of MO lipid on liver function tests, electrolytes, coagulation, and inflammation markers in the per-protocol population

From: Comparing mixed oil to soybean oil lipid emulsion in patients on home parenteral nutrition: a pilot prospective double-blind, crossover, randomized trial

Outcomes

Ā 

Least squares mean change from baselineb

Difference in mean change (SOā€“MO)

na

SO

MO

Least squares mean (95% CI)

Liver function test

ā€ƒALT (U/L)

12

2.56

5.22

-2.67 (-15.89ā€“10.56)

ā€ƒAST (U/L)

12

4.56

1.22

3.33 (-4.02ā€“10.69)

ā€ƒALP (U/L)

11

-0.33

-3.77

3.44 (-38.38ā€“45.26)

ā€ƒGGT (U/L)

10

5.69

1.98

3.71 (āˆ’ā€‰3.54ā€“10.97)

ā€ƒTotal bilirubin (Ī¼mol/L)

12

1.06

0.44

0.61 (āˆ’ā€‰2.55ā€“3.78)

ā€ƒConjugated bilirubin (Ī¼mol/L)

9

ā€‰āˆ’ā€‰0.33

ā€‰āˆ’ā€‰0.50

0.17 (āˆ’ā€‰0.73 ā€“1.06)

ā€ƒAlbumin (g/L)

12

ā€‰āˆ’ā€‰0.11

0.89

ā€‰āˆ’ā€‰1.00 (āˆ’ā€‰2.83ā€“0.83)

Coagulation markers

ā€ƒAPTT (s)

9

ā€‰āˆ’ā€‰0.65

ā€‰āˆ’ā€‰1.85

1.20 (āˆ’ā€‰2.62ā€“5.02)

ā€ƒINR

9

ā€‰āˆ’ā€‰0.10

ā€‰āˆ’ā€‰0.15

0.05 (āˆ’ā€‰0.25ā€“0.35)

Inflammation marker

ā€ƒCRP (mg/L)

8

ā€‰āˆ’ā€‰13.50

ā€‰āˆ’ā€‰1.58

ā€‰āˆ’ā€‰11.92 (āˆ’ā€‰49.06ā€“25.22)

General Biochemistry

ā€ƒHemoglobin (g/L)

12

ā€‰āˆ’ā€‰2.00

8.39

ā€‰āˆ’ā€‰10.39 (āˆ’ā€‰18.08ā€“ā€‰āˆ’ā€‰2.69)

ā€ƒWhite blood cells (X109/L)

12

ā€‰āˆ’ā€‰1.77

1.16

ā€‰āˆ’ā€‰2.93 (āˆ’ā€‰4.74ā€“ā€‰āˆ’ā€‰1.11)

ā€ƒPlatelets (X109/L)

12

ā€‰āˆ’ā€‰1.89

10.11

ā€‰āˆ’ā€‰12.00 (āˆ’ā€‰38.88ā€“14.88)

ā€ƒSodium (mmol/L)

12

ā€‰āˆ’ā€‰0.61

ā€‰āˆ’ā€‰1.50

.89 (āˆ’ā€‰2.05ā€“3.83)

ā€ƒPotassium (mmol/L)

12

0.18

ā€‰āˆ’ā€‰0.06

0.23 (āˆ’ā€‰0.07ā€“0.54)

ā€ƒBicarbonate (mmol/L)

12

0.89

ā€‰āˆ’ā€‰0.17

1.06 (āˆ’ā€‰3.52ā€“5.63)

ā€ƒChlorine (mmol/L)

12

0.22

ā€‰āˆ’ā€‰1.28

1.50 (āˆ’ā€‰1.64ā€“4.64)

ā€ƒPhosphate (mmol/L)

12

0.06

0.07

ā€‰āˆ’ā€‰0.00 (āˆ’ā€‰0.20ā€“0.20)

ā€ƒCalcium (mmol/L)

12

ā€‰āˆ’ā€‰0.02

0.02

ā€‰āˆ’ā€‰0.04 (āˆ’ā€‰0.14ā€“0.06)

ā€ƒMagnesium (mmol/L)

12

ā€‰āˆ’ā€‰0.00

ā€‰āˆ’ā€‰0.04

0.03 (āˆ’ā€‰0.03ā€“0.10)

  1. Abbreviations: SO Soybean oil, MO Mixed oil, ALT Alanine aminotransferase, AST Aspartate aminotransferase, ALP Alkaline phosphatase, GGT Gamma-glutamyl transferase, aPTT (s) Activated partial thromboplastin time, INR International normalized ratio, CRP C-reactive protein
  2. na number of participants with all four measurements at baseline and after 6Ā months
  3. bBaseline is defined as the time at study start for the first arm and month 7 for the second arm