Table 1 Pathogen distribution of late-onset infection events
Number of primary late-onset infection events and mortality | GloveCare arm N=63 | Standard arm N=48 | P-value (chi-square test) |
|---|---|---|---|
Sterile site infections,n (%) | |||
Any sterile site infection (culture positive meningitis, bacteremia, urinary tract infection) | 14 (22.2) | 15 (31.3) | 0.284 |
Gram positive | 9 | 7 | 0.965 |
Gram negative | 9 | 5 | 0.264 |
Meningitis (n (%)) | 3 (4.8) | 0 (0.0) | 0.257 (FE) |
Gram-positive | 2 (66.7) | ||
Gram-negative | 1 (33.3) | ||
Mean duration of antibiotic therapy (SD) | 29.33 (16.4) | ||
Mean C-reactive protein (CRP, mg/L) (SD) | 124.25 (72.1) | ||
Bacteremia (n (%)) | 4 (6.3) | 6 (12.5) | 0.324 (FE) |
Gram-positive | 3 (75.0) | 0 (0.0) | 0.257 (FE) |
Gram-negative | 1 (25.0) | 5 (83.3) | 0.0831 (FE) |
Candida | 0 (0.0) | 1 (16.7) | |
Mean duration of antibiotic therapy (SD) | 14.25 (9.4) | 30.50 (26.5) | |
Mean C-reactive protein (CRP, mg/L) (SD) | 81.05 (81.7) | 139.42 (177.0) | |
Urinary Tract Infection (n (%)) | 7 (11.1) | 9 (18.8) | 0.256 (CS) |
Gram-positive | 4 (57.1) | 7 (77.8) | 0.203 (FE) |
Gram-negative | 3 (42.9) | 2 (28.6) | 1.00 (FE) |
Mean duration of antibiotic therapy (SD) | 9.29 (3.6) | 14.44 (12.3) | |
Mean C-reactive protein (CRP, mg/L) (SD) | 17.36 (15.7) | 21.70 (14.3) | |
Nonsterile site infections,n (%) | |||
Secondary infection outcomes | 49 (77.8) | 33 (68.8) | 0.284 |
Culture negative meningitis | 3 (4.8) | 0 (0.0) | 0.257 |
Mean duration of antibiotic therapy (SD) | 26.67 (16.3) | ||
Mean C-reactive protein (CRP, mg/L) (SD) | 30.67 (39.2) | ||
Single positive CONS blood culture (n (%)) | 11 (17.5) | 4 (8.3) | 0.164 |
Mean duration of antibiotic therapy (SD) | 9.27 (3.3) | 10.50 (4.8) | |
Mean C-reactive protein (CRP, mg/L) (SD) | 41.42(47.6) | 15.07 (24.1) | |
Abdominal infection (n (%)) | 4 (6.3) | 7 (14.6) | 0.203 |
Mean duration of antibiotic therapy (SD) | 14.75 (9.0) | 9.86 (5.2) | |
Mean C-reactive protein (CRP, mg/L) (SD) | 114.00 (91.5) | 68.91 (93.9) | |
Pneumonia (n (%)) | 9 (14.3) | 6 (12.5) | 0.785 |
Mean duration of antibiotic therapy (SD) | 9.89 (1.8) | 10.67 (6.1) | |
Mean C-reactive protein (CRP, mg/L) (SD) | 34.28 (23.0) | 47.15 (55.1) | |
Cellulitis (n (%)) | 2 (3.2) | 0 (0.0) | 0.505 |
Mean duration of antibiotic therapy (SD) | 9 (1.4) | ||
Mean C-reactive protein (CRP, mg/L) (SD) | 51.60 (17.7) | ||
Culture negative sepsis (n (%)) | 20 (31.7) | 16 (33.3) | 0.860 |
Mean duration of antibiotic therapy (SD) | 8.30 (3.4) | 8.75 (2.8) | |
Mean C-reactive protein (CRP, mg/L) (SD) | 52.04 (43.3) | 47.87 (76.6) | |
Time to first infection, among all patients with infection, days (n=75), mean (sd) (“Removing” time in additional precautions) | 20.1 (16.1) | 11.4 (8.3) | 0.004 |