Table 1 Secondary outcome measures

1. Number and cause of Emergency Department visits measured by patient-reported and routinely collected data at 3 and 6 months

2. Number and cause of primary care general practice visits measured by patient-reported and routinely collected data at 3 and 6 months

3. Mortality measured by routinely collected data at 6 months

4. Medication changes (prescribed) and taken (in the case of opioid substitution therapy where supervised) measured through patient-reported and routinely collected data at 3 and 6 months

5. Number and cause of hospitalisation measured by patient-reported and routinely collected data at 3 and 6 months

6. Intervention acceptability measured by qualitative interviews with patients, the intervention delivery team and stakeholders as an ongoing process evaluation

7. Generic health-related quality of life score and health thermometer score measured by EQ-5D-5L at 3 months and 6 months

8. Frailty measured by Fried’s adapted frailty phenotype at 3 months and 6 months

9. Respiratory health measured by Peak Expiratory Flow Rate, MRC Dyspnoea scale and COPD Assessment Test (CAT) at 3 months and 6 months

10. Blood pressure measured by blood pressure monitors at 3 months and 6 months

1. Number of participants experiencing drug overdoses not requiring an Emergency Department visit and the number of overdoses measured by patient-reported data at 3 months and 6 months

2. Number of participants (and number of times) referred to drug and alcohol services, rehab, mental health and GP, and the numbers attending subsequently measured by patient-reported and routinely collected data at 3 and 6 months

3. Numbers and time to commencement on opiate substitute treatment (OST)/benzodiazepine/heroin-assisted treatment and collecting ≥ 80% of daily doses measured by routinely collected data at 3 months and 6 months

4. Number of participants treated with and time to minimum therapeutic OST dose measured by routinely collected data at 3 months and 6 months

5. Dose of OST measured by routinely collected data at 3 months and 6 months

6. Number of missed appointments (with any team, including irregular discharges) and number of participants with missed appointments measured by routinely collected data at 3 months and 6 months

7. Number of persons and days in prison/criminal justice encounters measured by patient-reported data at 3 and 6 months

1. Housing tenure including night shelters, emergency accommodation measured by self-reported data and those provided by the council or third sector, or care home at 3 months and 6 months

2. Level of debt as self-reported by patients at 3 months and 6 months

3. Criminal justice encounters as self-reported by patients at 3 months and 6 months