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Table 3 Effect sizes for within-group differences in plasma AD biomarkers (reference: baseline)

From: Feasibility and preliminary effects of exercise interventions on plasma biomarkers of Alzheimer’s disease in the FIT-AD trial: a randomized pilot study in older adults with Alzheimer’s dementia

 

Plasma Ab42/40 ratio

t-tau

p-tau181

Difference (SDa)

Cohen’s db,c [95% CI]

Difference (SDa)

Cohen’s db,c [95% CI]

Difference (SDa)

Cohen’s db,c [95% CI]

Stretching

 vs. 3 months

0.002 (0.012)

0.16 [−0.22; 0.54]

−0.007 (0.277)

−0.02 [−0.60; 0.55]

0.069 (1.234)

0.06 [−0.45; 0.56]

 vs. 6 months

0.001 (0.012)

0.11 [−0.33; 0.55]

−0.020 (0.279)

−0.07 [−0.65; 0.51]

0.609 (1.417)

0.43 [−0.33; 1.19]

Cycling

 vs. 3 months

−0.001 (0.010)

−0.07 [−0.32; 0.19]

−0.002 (0.175)

−0.01 [−0.58; 0.55]

0.056 (1.416)

0.04 [−0.49; 0.57]

 vs. 6 months

−0.001 (0.010)

−0.10 [−0.38; 0.18]

−0.075 (0.215)

−0.35 [−0.87; 0.17]

0.101 (1.579)

0.06 [−0.48; 0.60]

  1. The sample sizes for the stretching and the cycling groups are 8 and 18, 8 and 15, and 8 and 17 at baseline, and 3 and 6 months, respective
  2. aPooled standard deviation, bCohen’s d: small (.2), medium (.5), and large (.8); cbootstrap estimation (number of replications=1010)