Table 1 Schedule of enrolment, interventions, and assessments

Enrolment:

 Initial eligibility screen

X

 Informed consent

X

 Demographic information

X

 Randomisation

X

Interventions:

 SMART + TAU

X

 Active control training + TAU

X

 TAU

X

Assessments:

 PDQ

X

X

X

 Symbol Digit Modalities Test (SDMT)

X

X

X

 RBANS

X

X

X

 Generalized Anxiety Disorder Scale-7 (GAD-7)

 Patient Health Questionnaire-9 (PHQ-9)

X

X

X

 Modified Fatigue Impact Scale–5-Item (MFIS-5)

X

X

X

 Personal Questionnaire (PQ)

X

X

X

 EQ-5D-5L

X

X

X

 MS Impact Scale–29 (MSIS-8D; v.2)

X

X

X

 ICECAP-A

X

X

X

 Service- and resource-use questionnaire

X

X

X

 Feedback interviews

X^a