Table 1 Inclusion and exclusion criteria

▪ Adults 18 to 60 years of age.

▪ Confirmed diagnosis of PoTS [2] and currently attending specialist out-patient clinics.

▪ Able to attend a PULSE centre 3 times over 7 months for outcome assessments.

▪ Access to appropriate IT infrastructure at home—Internet and Internet-enabled device (device can be provided on loan if required).

▪ Able to provide informed consent.

▪ Absolute contraindications to exercise as per international clinical guidelines [17, 18].

▪ Any serious mental health/cognitive issue that will prevent engagement with trial procedures or increase the risk of exercise complications.

▪ Unable to make suitable travel arrangements to outcomes assessments (transport can be organised if required).

▪ Currently undertaking structured exercise/physical activity equivalent to the Chief Medical Officer (CMO) guidelines (150 min moderate exercise per week or 75 min vigorous per week).

▪ Previous randomisation in the present trial.

▪ Pregnancy.

▪ Taken part in co-creation workshops to design the PULSE intervention/trial.