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Table 1 Inclusion and exclusion criteria

From: β-Hydroxy-β-methylbutyrate (HMB) supplementation and functional outcomes in multi-trauma patients: a study protocol for a pilot randomised clinical trial (BOOST trial)

Inclusion:

 Adults, ≥ 18 years of age

 Completed two full calendar days in ICU

 The predominant reason for ICU admission was a traumatic injury

 Allowed enteral/ oral nutrition at the time of randomisation

Exclusion:

 Death during ICU admission deemed to be inevitable

 Bilateral above knee amputation

 Patients assessed as requiring completely or predominantly parenteral nutrition

 Pregnancy

 Primary neuromuscular pathology present or strongly suspected this admission episode

 Presumed transection of the spinal cord at any level

 Medical decision treatment maker, participant or medical practitioner declined consent

 Limited research availability over enrolment timeframe

 Enrolment conflict with other research studies

 Unlikely to be able to participate in long term follow up measures

 Unable to obtain consent within 7 days from initial traumatic injury