Table 1 Literature review of DBS for the treatment of SIB and ASD
[29] Author | Age, sex | Behavior | DBS target (programming) | Pre-DBS score | Post-DBS score |
|---|---|---|---|---|---|
Sturm 2012 [30] | 13M | Self-aggression | Basolateral amygdala (120 μs, 130 Hz, 2–6.5 V) | Restraints do not prevent skin lesions and life threatening self-injury | Restraint of the wrists suffices and is well tolerated |
Stocco 2014 [31] | 19F | Self-picking | Globus pallidus internus (120 μs, 80 Hz, 3.3 V) | JHMRS 46 | JHMRS 4 |
Stocco 2014 [31] | 17M | Punching of arms and legs, biting | Globus pallidus internus (120 μs, 100 Hz, 2.5 V) + Anterior limb of internal capsule (210 μs 100 Hz 2.0 V) | JHMRS 67 | JHMRS 19 |
Benedetti-Isaac 2015 [32] | 27M | Aggressive behavior towards self | Posterior hypothalamus (90 μs, 185 Hz, 2.7 V) | OAS 9 | OAS 1 |
Benedetti-Isaac 2015 [32] | 16M | Self-aggression | Posterior hypothalamus (90 μs, 185 Hz, 2.8 V) | OAS 8 | OAS 8 (temporary improvement at 1 month) |
Segar 2015 [33] | 24F | Biting hands, picking skin | Nucleus accumbens (90 μs, 130 Hz, 8 V) | GAF 20 | GAF 50-60 |
Park 2016 [34] | 13M | Self-mutilation, face-hitting causing fractures | Nucleus accumbens (90 μs, 130 Hz, 3–5 V) | CGI-S 6 ABC 106 CY-BOCS 22 K-ARS 54 SRS 101 | CGI-S 4 ABC 40 CY-BOCS 7 K-ARS 36 SRS 98 |
Kakko 2019 [29] | 19M | Aggression, self-mutilation, lacerations | Globus pallidus internus | Â | Self-destructive behavior ceased |
Doshi 2019 [35] | 42F | Hitting, violent outbursts | Nucleus accumbens (60 μs, 130 Hz, 2.6 V) | YBOCS 19 HDS 20 HAS 30 SCQ 26 | YBOCS 5 HDS 15 HAS 18 SCQ 16 |