Table 3 Concomitant medications

• Intra-articular steroid, particularly when into the hands or within 3 months of the week 24 visit

• Oral steroid, particularly when for longer than 5 days consecutively or within 6 weeks of the week 24 visit

• Intramuscular steroid at any point during the study

• Use of intra-articular hyaluronan to a hand joint at any point during the study

• New prescription of non-steroidal anti-inflammatory drugs or other analgesic, particularly when within 4 weeks of the week 24 visit

• Initiation of treatment such as glucosamine or chondroitin at any point

• Initiation of hand exercises or other relevant non-pharmacological therapy at any point