Table 1 Outcome measures

• Rates of eligible participant identification (screening period)

• Rates of recruitment/randomisation from different sources (screening period)

• Retention rates (throughout study)

• Study medication compliance ^a

• Bang’s Blinding Index (likelihood of unblinding) [40] ^a

• Average hand pain (rated over 14 days preceding the study visit)^{c a}

• Pain manikin–capturing pain in other joints in the 4 weeks preceding the study visit^a

• Functional Index for Hand OsteoArthritis (FIHOA) questionnaire [41, 42]^b

• Grip strength, by Jamar dynamometer [43]^b

• EQ-5D-5L questionnaire [44, 45]^b

• Menopause-specific Quality of Life (MENQOL) questionnaire (Intervention 1-month recall version) [38, 46, 47]^b

• Greene Climacteric Scale [48]^b

• Cosmesis score (single question, Michigan Hand Questionnaire) [49]^b

• Investigator-recorded tender and swollen joint counts ^a

• Photographic recording of swollen hand joints ^a