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Table 5 Neonatal proof of concept outcomes

From: Standard care informed by the result of a placental growth factor blood test versus standard care alone in women with reduced fetal movement at or after 36+0 weeks’ gestation: a pilot randomised controlled trial

 Control (n = 107)Intervention (n = 109)
Composite adverse pregnancy outcome14 (4%)9 (8%)
 Stillbirth or death before discharge0 (–)0 (–)
 5-min Apgar score < 71 (1%)1 (1%)
 Umbilical artery pH < 7.050 (–)4 (4%)
 Admission to neonatal unit for > 48 h4 (4%)4 (4%)
Other neonatal outcomes  
 SGA baby (INTERGROWTH-21st birthweight standard)2 (2%)9 (8%)
 SGA baby (GROW birthweight standard)7 (7%)15 (14%)
 Length of stay in hospital (days)  
  Median (25th, 75th centile)1.2 (0.8, 2.2)1.2 (0.7, 2.4)
Outcomes for babies admitted to neonatal unitn = 5n = 7
 Use of therapeutic cooling0 (-)0 (–)
 Duration of mechanical respiratory support  
  < 24 h0 (–)2 (29%)
  1–2 days2 (40%)1 (14%)
 Length of stay in neonatal unit2  
  Normal caren = 0n = 1
   < 24 h0 (–)0 (–)
   1–2 days0 (–)1 (14%)
   > 2 days0 (–)0 (–)
  Special caren = 5n = 6
   <24 h0 (–)1 (14%)
   1–2 days2 (40%)2 (29%)
   > 2 days3 (60%)3 (43%)
  High dependency caren = 5n = 2
   < 24 h0 (–)1 (14%)
   1–2 days1 (20%)1 (14%)
   > 2 days2 (40%)0 (–)
  Intensive caren = 1n = 1
   < 24 h0 (–)1 (14%)
   1–2 days1 (20%)0 (–)
   > 2 days0 (–)0 (–)
  1. All data are N (%) unless indicated
  2. 1This means at least one of stillbirth or death before discharge, 5-min Apgar score of < 7, umbilical artery pH < 7.05, or admission to the neonatal unit for > 48 h. If umbilical artery pH was missing (n = 82) and all other components did not indicate the composite adverse pregnancy outcome, an umbilical artery pH ≥ 7.05 was assumed for the purposes of calculating the composite
  3. 2Levels of care are not mutually exclusive