Standard care informed by the result of a placental growth factor blood test versus standard care alone in women with reduced fetal movement at or after 36+0 weeks’ gestation: a pilot randomised controlled trial

Table 5 Neonatal proof of concept outcomes

	Control (n = 107)	Intervention (n = 109)
Composite adverse pregnancy outcome¹	4 (4%)	9 (8%)
Stillbirth or death before discharge	0 (–)	0 (–)
5-min Apgar score < 7	1 (1%)	1 (1%)
Umbilical artery pH < 7.05	0 (–)	4 (4%)
Admission to neonatal unit for > 48 h	4 (4%)	4 (4%)
Other neonatal outcomes
SGA baby (INTERGROWTH-21st birthweight standard)	2 (2%)	9 (8%)
SGA baby (GROW birthweight standard)	7 (7%)	15 (14%)
Length of stay in hospital (days)
Median (25th, 75th centile)	1.2 (0.8, 2.2)	1.2 (0.7, 2.4)
Outcomes for babies admitted to neonatal unit	n = 5	n = 7
Use of therapeutic cooling	0 (-)	0 (–)
Duration of mechanical respiratory support
< 24 h	0 (–)	2 (29%)
1–2 days	2 (40%)	1 (14%)
Length of stay in neonatal unit²
Normal care	n = 0	n = 1
< 24 h	0 (–)	0 (–)
1–2 days	0 (–)	1 (14%)
> 2 days	0 (–)	0 (–)
Special care	n = 5	n = 6
<24 h	0 (–)	1 (14%)
1–2 days	2 (40%)	2 (29%)
> 2 days	3 (60%)	3 (43%)
High dependency care	n = 5	n = 2
< 24 h	0 (–)	1 (14%)
1–2 days	1 (20%)	1 (14%)
> 2 days	2 (40%)	0 (–)
Intensive care	n = 1	n = 1
< 24 h	0 (–)	1 (14%)
1–2 days	1 (20%)	0 (–)
> 2 days	0 (–)	0 (–)

All data are N (%) unless indicated
¹This means at least one of stillbirth or death before discharge, 5-min Apgar score of < 7, umbilical artery pH < 7.05, or admission to the neonatal unit for > 48 h. If umbilical artery pH was missing (n = 82) and all other components did not indicate the composite adverse pregnancy outcome, an umbilical artery pH ≥ 7.05 was assumed for the purposes of calculating the composite
²Levels of care are not mutually exclusive

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