Table 4 Maternal proof of concept outcomes
Control (n = 107) | Intervention (n = 109) | |
|---|---|---|
Complications of pregnancy after baseline visit1 | 5 (5%) | 15 (14%) |
Antepartum haemorrhage | 2 (2%) | 2 (2%) |
Hypertension in pregnancy | 2 (2%) | 3 (3%) |
Obstetric cholestasis | 2 (2%) | 1 (1%) |
Prelabour rupture of membranes | 1 (1%) | 9 (8%) |
Other2 | 1 (1%) | 3 (3%) |
Onset of labour | ||
Spontaneous | 49 (46%) | 50 (46%) |
Induced | 48 (45%) | 49 (45%) |
Caesarean section | 10 (9%) | 10 (9%) |
If caesarean section, grade | ||
Grade 1 (emergency) | 2 (20%) | 1 (10%) |
Grade 4 (elective) | 8 (80%) | 9 (90%) |
Reasons for induction3 | ||
Recommended by sFlt-1/PlGF test result | 0 (–) | 13 (27%) |
Gestational age > 41 weeks | 8 (17%) | 7 (14%) |
Term (> 37 weeks) prelabour rupture of membranes > 24 h | 3 (6%) | 5 (10%) |
Fetal growth restriction | 2 (4%) | 1 (2%) |
Reduced fetal movements | 29 (60%) | 25 (51%) |
Pregnancy-induced hypertension | 0 (–) | 1 (2%) |
Preeclampsia | 1 (2%) | 0 (–) |
Obstetric cholestasis | 1 (2%) | 2 (4%) |
Gestational diabetes | 1 (2%) | 2 (4%) |
Maternal request | 2 (4%) | 3 (6%) |
Other | 14 (29%) | 5 (10%) |
Reasons for elective caesarean4 | ||
Recommended by sFlt-1/PlGF test result | 0 (–) | 1 (11%) |
Previous caesarean section | 4 (50%) | 5 (56%) |
Non-cephalic presentation | 2 (25%) | 3 (33%) |
Presumed fetal compromise | 1 (13%) | 0 (–) |
Maternal request | 0 (–) | 2 (22%) |
Previous 3rd/4th degree tear | 0 (–) | 1 (11%) |
Other | 2 (25%) | 3 (33%) |
Mode of delivery | ||
Vaginal birth | 72 (67%) | 64 (59%) |
Instrumental vaginal birth | 14 (13%) | 25 (23%) |
Emergency caesarean section | 13 (12%) | 11 (10%) |
Elective caesarean section | 8 (7%) | 9 (8%) |