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Table 4 Maternal proof of concept outcomes

From: Standard care informed by the result of a placental growth factor blood test versus standard care alone in women with reduced fetal movement at or after 36+0 weeks’ gestation: a pilot randomised controlled trial

 Control (n = 107)Intervention (n = 109)
Complications of pregnancy after baseline visit15 (5%)15 (14%)
 Antepartum haemorrhage2 (2%)2 (2%)
 Hypertension in pregnancy2 (2%)3 (3%)
 Obstetric cholestasis2 (2%)1 (1%)
 Prelabour rupture of membranes1 (1%)9 (8%)
 Other21 (1%)3 (3%)
Onset of labour
 Spontaneous49 (46%)50 (46%)
 Induced48 (45%)49 (45%)
 Caesarean section10 (9%)10 (9%)
  If caesarean section, grade
   Grade 1 (emergency)2 (20%)1 (10%)
   Grade 4 (elective)8 (80%)9 (90%)
  Reasons for induction3
   Recommended by sFlt-1/PlGF test result0 (–)13 (27%)
   Gestational age > 41 weeks8 (17%)7 (14%)
   Term (> 37 weeks) prelabour rupture of membranes > 24 h3 (6%)5 (10%)
   Fetal growth restriction2 (4%)1 (2%)
   Reduced fetal movements29 (60%)25 (51%)
   Pregnancy-induced hypertension0 (–)1 (2%)
   Preeclampsia1 (2%)0 (–)
   Obstetric cholestasis1 (2%)2 (4%)
   Gestational diabetes1 (2%)2 (4%)
   Maternal request2 (4%)3 (6%)
   Other14 (29%)5 (10%)
  Reasons for elective caesarean4
   Recommended by sFlt-1/PlGF test result0 (–)1 (11%)
   Previous caesarean section4 (50%)5 (56%)
   Non-cephalic presentation2 (25%)3 (33%)
   Presumed fetal compromise1 (13%)0 (–)
   Maternal request0 (–)2 (22%)
   Previous 3rd/4th degree tear0 (–)1 (11%)
   Other2 (25%)3 (33%)
Mode of delivery
 Vaginal birth72 (67%)64 (59%)
 Instrumental vaginal birth14 (13%)25 (23%)
 Emergency caesarean section13 (12%)11 (10%)
 Elective caesarean section8 (7%)9 (8%)
  1. 1Complications of pregnancy are not mutually exclusive
  2. 2Others include spontaneous rupture of membranes, viral meningitis, polyhydramnios and genital ulcer (microbiology confirmed HSV-1)
  3. 3Reasons for induction are not mutually exclusive; denominator is the number of participants who were induced
  4. 4Reasons for elective caesarean are not mutually exclusive; denominator is the number of participants who had an elective caesarean section