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Table 1 Baseline characteristics

From: Standard care informed by the result of a placental growth factor blood test versus standard care alone in women with reduced fetal movement at or after 36+0 weeks’ gestation: a pilot randomised controlled trial

Characteristic

Control (n = 107)

Intervention (n = 109)

Total (n = 216)

Maternal age (years)

 Mean (SD)

29.2 (5.7)

30.4 (5.4)

29.8 (5.6)

Gestational age at randomisation (weeks)

 Mean (SD)

37.8 (1.2)

37.9 (1.4)

37.9 (1.3)

Stratification variable

  ≥ 40+0

7 (7%)

10 (9%)

17 (8%)

Ethnicity

 White

93 (87%)

93 (85%)

186 (86%)

 Black

1 (1%)

5 (5%)

6 (3%)

 South Asian

7 (7%)

6 (6%)

13 (6%)

 East Asian

3 (3%)

3 (3%)

6 (3%)

 Mixed Race

1 (1%)

2 (2%)

3 (1%)

 Others

2 (2%)

0 (–)

2 (1%)

BMI at booking visit

 Mean (SD)

26.8 (5.6)

27.4 (6.3)

27.1 (6.0)

Parity

 0

48 (45%)

53 (49%)

101 (47%)

 1

37 (35%)

36 (33%)

73 (34%)

 ≥ 2

22 (20%)

20 (18%)

42 (19%)

Number of previous stillbirths

 1

1 (1%)

1 (1%)

2 (1%)

Obstetric history for previous pregnancies1

 Yes

23 (21%)

19 (17%)

42 (19%)

Obstetric cholestasis

0 (–)

4 (4%)

4 (2%)

Placental abruption

2 (2%)

1 (1%)

3 (1%)

Preeclampsia

5 (5%)

1 (1%)

6 (3%)

SGA baby

5 (5%)

2 (2%)

7 (3%)

Other

16 (15%)

14 (13%)

30 (14%)

Diagnoses in current pregnancy1

 Antepartum haemorrhage

0 (–)

1 (1%)

1 (< 1%)

 Hypertension

1 (1%)

1 (1%)

2 (1%)

 Obstetric cholestasis

0 (0%)

2 (2%)

2 (1%)

 Other2

6 (6%)

4 (4%)

10 (5%)

Past medical history1

15 (14%)

12 (11%)

27 (13%)

 Hypertension

4 (4%)

0 (–)

4 (2%)

 Diabetes

2 (2%)

0 (–)

2 (1%)

 Other3

10 (9%)

12 (11%)

22 (10%)

Estimated fetal weight from ultrasound scan (g)

 Mean (SD)

3255 (520.6)

3109 (500.1)

3181 (514.4)

Centile usingINTERGROWTH-21stbirthweight standard

 Mean (SD)

67.4 (24.7)

59.1 (25.8)

63.3 (25.6)

 SGA fetus

3 (3%)

5 (5%)

8 (4%)

Prescribed medication at the trial entry1

 Aspirin

8 (7%)

7 (6%)

15 (7%)

 Other4

10 (9%)

11 (10%)

21 (10%)

Substance misuse during this pregnancy

 Benzodiazepine

0 (–)

3 (3%)

3 (1%)

Cigarette smoking status during this pregnancy

 Currently smoking

5 (5%)

3 (3%)

8 (4%)

 Stopped smoking in this pregnancy

5 (5%)

4 (4%)

9 (4%)

 Not smoked in this pregnancy

97 (91%)

102 (94%)

199 (92%)

Duration women concerned about baby’s movements (h)

 0–24

76 (71%)

72 (66%)

148 (69%)

 25–48

9 (8%)

18 (17%)

27 (13%)

 > 48

22 (21%)

19 (17%)

41 (19%)

Absent fetal movements

 Yes

37 (35%)

51 (47%)

88 (41%)

 No

70 (65%)

58 (53%)

128 (59%)

  1. All data are N (%) unless indicated
  2. 1Categories are not mutually exclusive
  3. 2Others include anxiety and depression (n = 2), gestational diabetes, placenta praevia, medullary sponge kidney, hypothyroidism, gallstones/pancreatitis, type 1 diabetes, GBS, thrush and fibromyalgia (not mutually exclusive)
  4. 3Others include significant cardiac disease (n = 3), significant gastrointestinal problems (n = 3), significant mental health problems (n = 10), renal disease (n = 1) and thyroid disease (n = 7)
  5. 4Others include antidepressants (n = 14), benzodiazepines (n = 3) and low molecular weight heparin (n = 6)