|
Measures
|
Baseline (week 0)
|
Visit 4 (week2)
|
Visit 8 (week 4)
|
4-week follow-up (week 8)
|
8-week follow-up (week 12)
|
12-week follow-up (week 16)
|
|---|
|
N
|
Mean
|
SD
|
N
|
Mean
|
SD
|
N
|
Mean
|
SD
|
N
|
Mean
|
SD
|
N
|
Mean
|
SD
|
N
|
Mean
|
SD
|
|---|
|
SPA (peak pain–baseline pain)
|
|
Pre
|
10
|
2.35
|
0.94
|
8
|
0.50
|
0.76
|
7
|
0.00
|
0.16
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
|
Post
|
10
|
1.35
|
1.00
|
8
|
0.63
|
0.74
|
7
|
0.57
|
1.27
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
|
Pain severity
|
|
Worst
|
10
|
5.30
|
2.21
|
8
|
3.87
|
2.17
|
7
|
3.00
|
2.00
|
10
|
4.40
|
2.99
|
10
|
4.30
|
2.67
|
10
|
3.70
|
2.41
|
|
At least
|
10
|
1.70
|
1.83
|
8
|
1.13
|
1.36
|
7
|
0.14
|
0.38
|
10
|
2.40
|
3.06
|
10
|
2.30
|
2.98
|
10
|
1.80
|
3.05
|
|
Average
|
10
|
3.80
|
1.62
|
8
|
2.25
|
1.75
|
7
|
1.29
|
1.25
|
10
|
3.40
|
2.80
|
10
|
3.20
|
2.66
|
10
|
2.70
|
2.67
|
|
Right now
|
10
|
2.80
|
1.99
|
8
|
1.50
|
1.07
|
7
|
1.57
|
2.23
|
10
|
3.00
|
3.37
|
10
|
2.70
|
3.37
|
10
|
2.10
|
2.89
|
|
Index
|
10
|
3.4
|
2.28
|
8
|
2.19
|
1.89
|
7
|
1.50
|
1.86
|
10
|
3.30
|
3.03
|
10
|
3.1
|
2.92
|
10
|
2.6
|
2.75
|
|
WOMAC
|
|
Pain
|
10
|
7.10
|
2.38
|
8
|
5.38
|
2.26
|
7
|
4.14
|
2.67
|
10
|
6.50
|
4.25
|
10
|
7.10
|
4.33
|
10
|
6.10
|
4.48
|
|
Stiffness
|
10
|
3.00
|
0.94
|
8
|
3.00
|
1.51
|
7
|
2.00
|
1.16
|
10
|
3.60
|
1.65
|
10
|
3.50
|
1.96
|
10
|
2.70
|
1.89
|
|
Physical Function
|
10
|
25.20
|
6.96
|
8
|
21.38
|
10.03
|
7
|
10.71
|
7.85
|
10
|
23.00
|
20.13
|
10
|
24.40
|
19.12
|
10
|
19.10
|
17.84
|
|
Total
|
10
|
35.30
|
8.98
|
8
|
29.75
|
13.01
|
7
|
16.86
|
10.72
|
10
|
33.10
|
25.00
|
10
|
35.00
|
25.07
|
10
|
27.90
|
23.81
|
|
GROC Function
|
–
|
–
|
–
|
8
|
7.00
|
0.76
|
7
|
7.86
|
0.69
|
10
|
6.60
|
2.22
|
10
|
6.90
|
2.38
|
10
|
7.60
|
1.58
|
|
GROC Pain
|
–
|
–
|
–
|
8
|
6.50
|
1.07
|
7
|
7.71
|
1.50
|
10
|
6.30
|
2.14
|
10
|
6.80
|
2.30
|
10
|
7.20
|
1.93
|
|
Satisfaction
|
–
|
–
|
–
|
8
|
9.62
|
1.60
|
7
|
9.57
|
0.98
|
10
|
9.50
|
2.01
|
10
|
8.90
|
3.04
|
10
|
9.30
|
1.95
|
|
6MWT (m)
|
|
Pre
|
10
|
321.97
|
88.53
|
8
|
393.37
|
92.82
|
7
|
428.95
|
90.15
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
|
Post
|
10
|
317.77
|
89.80
|
8
|
379.44
|
80.30
|
6
|
433.05
|
100.56
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
|
Pressure pain threshold–mean of peripatellar sites (N)
|
|
Most tender knee
|
10
|
51.89
|
36.27
|
–
|
–
|
–
|
7
|
60.29
|
25.01
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
|
Least tender knee
|
10
|
52.70
|
28.57
|
–
|
–
|
–
|
7
|
73.98
|
62.05
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
|
Pressure pain threshold – standard site over tibialis anterior (N)
|
|
Most tender knee
|
10
|
38.10
|
18.87
|
–
|
–
|
–
|
7
|
42.64
|
12.52
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
|
Least tender knee
|
10
|
40.20
|
16.10
|
–
|
–
|
–
|
7
|
48.50
|
18.93
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
- SPA sensitivity to physical activity, WOMAC Western Ontario and McMaster Universities Osteoarthritis Index, 6MWT 6-minute walk test, GROC global rating of change, N Newtons
