Skip to main content

Table 4 Anthropometry and Apgar scores at birth, and anthropometry, neurodevelopmental outcomes and breastfeeding practices at 12 weeks postpartum for infants exposed to food-insecure conditions compared to those who were not

From: Does in utero HIV exposure and the early nutritional environment influence infant development and immune outcomes? Findings from a pilot study in Pretoria, South Africa

Do you worry about food runout?

 

No

Yes

p value (unadjusted)

p value (adjusted)

Hedge’s g or RR (95% CI)

ω2

 

n = 14

n = 17

 Gestational age at delivery (weeks)

38.8 ± 1.81

38.4 ± 1.66

0.49

–

–

–

 EBF at 12 weeks PP (n [%])

11 (78.6)

7 (41.4)

0.07

–

–

–

 Infant anthropometry and Apgar at birth1

  Head circumference z-score

− 1.49 ± 0.99

− 0.81 ± 1.46

0.15

0.35

0.37 (− 0.40, 1.14)

0.00

  Weight z-score

− 0.59 ± 1.00

− 1.08 ± 1.10

0.22

0.20

0.51 (− 0.27, 1.29)

0.02

  Length z-score

− 1.20 ± 1.41

− 1.05 ±. 2.10

0.82

0.35

0.38 (− 0.41, 1.16)

0.00

  BMI z-score

− 0.02 ± 1.81

− 0.94 ± 1.64

0.16

0.59

0.22 (− 0.56, 1.00)

0.00

  Brain-to-body weight ratio

9.65 (8.90, 10.3)

10.4 (9.70, 12.0)

0.05

0.17

0.56 (− 0.23, 1.34)

0.04

  Stunting at birth2 (n [%])

3 (21.4)

8 (47.1)

0.26

–

2.04 (0.67, 6.21)

–

  Apgar 1-min score

9.00 (8.75, 9.00)

8.00 (8.00, 9.00)

0.02

0.18

0.55 (− 0.25, 1.33)

0.03

  Apgar 5-min score

10.0 (9.00, 10.0)

9.00 (9.00, 9.00)

0.02

0.01

1.19 (0.32, 2.03)

0.21

 Infant anthropometry in infants aged 12 weeks1

  Head circumference z-score

− 1.47 (− 2.12, − 0.97)

− 1.07 (− 1.94, − 0.62)

0.36

0.54

0.25 (− 0.53, 1.01)

0.00

  Weight z-score

− 0.08 (− 0.77, 0.23)

− 0.45 (− 1.26, 0.14)

0.45

0.22

0.52 (− 0.30, 1.32)

0.02

  Length z-score

− 0.84 ± 0.64

− 1.52 ± 0.99

0.04

0.01

1.14 (0.29, 1.96)

0.17

  BMI z-score

0.37 ± 0.96

0.19 ± 1.74

0.72

0.73

0.14 (− 0.66, 0.94)

0.00

  Brain-to-body weight ratio

7.40 (6.84, 7.74)

7.61 (7.11, 7.91)

0.18

0.18

0.70 (− 0.32, 1.69)

0.04

  Weight gain (birth to 12 weeks PP; kg/day)

0.03 ± 0.01

0.03 ± 0.01

0.49

0.34

0.41 (− 0.42, 1.22)

0.00

  Stunting at 12 weeks postpartum2 (n [%])

1 (7.14)

4 (23.5)

0.35

–

3.29 (0.41, 26.2)

–

 Attainment of all 1-3 month GMCD milestones3 (n [%])

n = 13

n = 9

    

  Expressive language

13 (100)

8 (88.9)

0.41

–

0.89 (0.71, 1.12)

–

  Receptive language

11 (84.6)

7 (77.8)

1.00

–

0.92 (0.61, 1.40)

–

  Large movement

13 (100)

6 (66.7)

0.06

–

0.67 (0.42, 1.06)

–

  Fine movement

13 (100)

9 (100)

-

–

–

–

  Relating and response behaviour

13 (100)

7 (77.8)

0.16

–

0.78 (0.55, 1.10)

–

  Play behaviour

12 (92.3)

6 (66.7)

0.26

–

0.72 (0.44, 1.18)

–

Do you experience food runout?

 

No

Yes

p value (unadjusted)

p value (adjusted)

Hedge’s g or RR (95% CI)

ω2

 

n = 16

n = 15

 Gestational age at delivery (weeks)

38.6 ± 1.79

38.5 ± 1.69

0.96

–

–

–

 EBF at 12 weeks PP (n [%])

13 (81.3)

5 (33.3)

0.01

–

0.41 (0.19, 0.87)

–

 Infant anthropometry and Apgar at birth1

  Head circumference z-score

− 1.39 ± 0.96

− 0.82 ± 1.56

0.23

0.50

0.28 (− 0.52, 1.07)

0.00

  Weight z-score

− 0.59 ± 0.94

− 1.14 ± 1.15

0.16

0.14

0.62 (− 0.20, 1.42)

0.04

  Length z-score

− 1.21 ± 1.36

− 1.02 ± 2.20

0.78

0.15

0.60 (− 0.22, 1.41)

0.04

  BMI z-score

− 0.02 ± 1.68

− 1.06 ± 1.69

0.10

0.72

0.15 (− 0.65, 0.94)

0.00

  Brain-to-body weight ratio

9.78 (8.95, 10.4)

10.5 (9.54, 12.0)

0.09

0.19

0.55 (− 0.28, 1.36)

0.03

  Stunting at birth2 (n [%])

4 (25.0)

7 (46.7)

0.45

–

1.75 (0.65, 4.75)

–

  Apgar 1-min score

9.00 (8.25, 9.00)

8.00 (8.00, 9.00)

0.02

0.17

0.58 (− 0.25, 1.39)

0.03

  Apgar 5-min score

9.50 (9.00, 10.0)

9.00 (9.00, 9.00)

0.006

0.02

1.05 (0.18, 1.90)

0.24

 Infant anthropometry in infants aged 12 weeks1

  Head circumference z-score

− 1.47 (− 2.21, − 0.88)

− 1.07 (− 1.94, − 0.62)

0.32

0.90

0.05 (− 0.74, 0.84)

0.00

  Weight z-score

− 0.08 (− 0.66, 0.26)

− 0.46 (− 1.47, 0.11)

0.28

0.07

0.82 (− 0.08, 1.69)

0.08

  Length z-score

− 0.85 ± 0.61

− 1.60 ± 1.02

0.02

0.002

1.38 (0.48, 2.25)

0.22

  BMI z-score

0.41 ± 0.96

0.11 ± 1.82

0.58

0.43

0.35 (− 0.51, 1.20)

0.00

  Brain-to-body weight ratio

7.21 (6.88, 7.69)

7.72 (7.29, 8.12)

0.03

0.17

0.75 (− 0.32, 1.80)

0.04

  Weight gain (birth to 12 weeks PP; kg/day)

0.03 ± 0.01

0.03 ± 0.01

0.38

0.17

0.64 (− 0.27, 1.54)

0.04

  Stunting at 12 weeks postpartum2 (n [%])

1 (6.25)

4 (26.7)

0.17

–

4.27 (0.54, 34.0)

–

 Attainment of all 1–3-month GMCD milestones3 (n [%])

n = 14

n = 8

    

  Expressive language

14 (100)

7 (87.5)

0.36

–

0.88 (0.67, 1.14)

–

  Receptive language

11 (78.6)

7 (87.5)

1.00

–

1.11 (0.76, 1.63)

–

  Large movement

13 (92.9)

6 (75.0)

0.53

–

0.91 (0.53, 1.24)

–

  Fine movement

14 (100)

8 (100)

–

–

–

–

  Relating and response behaviour

13 (92.9)

7 (87.5)

1.00

–

0.94 (0.70, 1.27)

–

  Play behaviour

12 (85.7)

6 (75.0)

 

–

0.88 (0.56, 1.38)

–

Are you able to afford balanced meals?

 

Yes

No

p value (unadjusted)

p value (adjusted)

Hedge’s g or RR (95% CI)

ω2

 

n = 9

n = 22

 Gestational age at delivery (weeks)

38.2 ± 1.99

38.7 ± 1.62

0.51

–

–

–

 EBF at 12 weeks PP (n [%])

8 (88.9)

9 (42.9)

0.04

–

0.51 (0.31, 0.85)

–

 Infant anthropometry and Apgar at birth1

  Head circumference z-score

− 1.71 ± 1.14

− 0.87 ± 1.30

0.10

0.13

0.68 (− 0.20, 1.55)

0.05

  Weight z-score

− 0.83 ± 0.93

− 0.87 ± 1.14

0.94

0.99

0.004 (− 0.85, 0.85)

0.00

  Length z-score

− 0.98 ± 1.35

− 1.18 ± 1.99

0.79

0.19

0.59 (− 0.30, 1.46)

0.03

  BMI z-score

− 0.64 ± 1.61

− 0.50 ± 1.83

0.84

0.35

0.42 (− 0.45, 1.29)

0.00

  Brain-to-body weight ratio

9.54 (8.97, 10.4)

10.1 (9.38, 11.4)

0.31

0.37

0.40 (− 0.47, 1.25)

0.00

  Stunting at birth2 (n [%])

2 (22.2)

9 (40.9)

0.42

–

1.93 (0.52, 7.21)

–

  Apgar 1-min score

9.00 (8.50, 9.00)

8.00 (8.00, 9.00)

0.11

0.11

0.73 (− 0.16, 1.60)

0.05

  Apgar 5-min score

10.0 (9.00, 10.0)

9.00 (9.00, 9.00)

0.04

0.06

0.88 (− 0.02, 1.76)

0.10

 Infant anthropometry in infants aged 12 weeks1

  Head circumference z-score

− 1.47 (− 2.17, − 0.80)

− 1.34 (− 1.95, − 0.79)

0.71

0.48

0.31 (− 0.55, 1.16)

0.00

  Weight z-score

− 0.41 (− 0.83, 0.38)

− 0.13 (− 1.12, 0.14)

0.77

0.11

0.75 (− 0.16, 1.64)

0.06

  Length z-score

− 1.14 (− 1.45, − 0.69)

− 1.02 (− 1.80, − 0.38)

0.80

0.21

0.55 (− 0.32, 1.41)

0.02

  BMI z-score

0.64 ± 1.00

0.12 ± 1.55

0.36

0.18

0.62 (− 0.28, 1.51)

0.04

  Brain-to-body weight ratio

7.48 (7.05, 7.68)

7.59 (7.03, 7.88)

0.56

0.41

0.39 (− 0.52, 1.28)

0.00

  Weight gain (birth to 12 weeks PP; kg/day)

0.03 ± 0.01

0.03 ± 0.01

0.44

0.08

0.83 (− 0.10, 1.73)

0.08

  Stunting at 12 weeks postpartum2 (n [%])

1 (11.0)

4 (18.2)

1.00

–

1.64 (0.21, 12.7)

–

 Attainment of all 1–3-month GMCD milestones3 (n[%])

n = 7

n = 15

    

  Expressive language

7 (100)

14 (93.3)

1.00

–

0.93 (0.82, 1.07)

–

  Receptive language

6 (85.7)

12 (80.0)

1.00

–

0.93 (0.63, 1.39)

–

  Large movement

7 (100)

12 (80.0)

0.52

–

0.80 (0.62, 1.03)

–

  Fine movement

7 (100)

15 (100)

–

–

–

–

  Relating and response behaviour

7 (100)

13 (86.7)

1.00

–

0.87 (0.71, 1.06)

–

  Play behaviour

7 (100)

11 (73.3)

0.26

–

0.73 (0.54, 1.00)

–

  1. Data from mother-infant dyads that attended follow-up are presented mean ± SD (ANOVA to test equality of means for normal data with equal variance) or median (IQR; Kruskal-Wallis/Wilcoxon test to test equality of medians for non-parametric data or Welch’s test to test equality of means for normal data with unequal variance) with p values from one-way analysis of variance and adjusted multiple variable regression models. Hedge’s g and RR are reported as effect size estimates for continuous and categorical infant outcome data, respectively. Omega square (ω2) denotes variance accounted for by the model. Differences in proportion of infants exclusively breastfed (EBF) at follow-up were assessed by Fisher’s exact test (2-tail). Infant anthropometry was adjusted for maternal age, maternal weight and gestational age. BBR, Apgar score (1 and 5 min) and weight gain (birth to 12 weeks PP; kg/day) were adjusted for maternal age, maternal weight, gestational age and infant sex 
  2. RR relative risk, PP postpartum
  3. 1All infant anthropometric measures are standardised according to WHO child growth standards [28]
  4. 2Stunting is determined by <− 2 SD length-for-age standardised z-score according to WHO child growth standards [28]
  5. 3For fine movement milestones at 1–3 months, all infants in both groups met all milestones so no comparisons were made. There was only 1 HUU infant who was 3–5 months at follow-up, so no comparisons for GMCD 3–5-month milestones were made between the two groups