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Table 3 Outcome definitions

From: Unfractionated heparin in acute chest syndrome: a pilot feasibility randomized controlled trial of unfractionated heparin vs. standard of care in acute chest syndrome

Outcome

Outcome definition

Onset

Resolution

Duration of hospitalization (measured in hours)

Duration of hospitalization

Randomization

Discharge from hospital

Duration of hypoxemia (measured in hours)

Arterial oxygen saturation less than 90%

Randomization

Failure to meet criteria for hypoxemia on 3 consecutive assessments or study completion

Duration of fever (measured in hours)

Body temperature greater than or equal to 38.0 °C

Randomization

Failure to meet criteria for fever on 3 consecutive assessments or study completion

Duration of leukocytosis (measured in hours)

White blood cell count greater than 10,000 per liter

Randomization

Failure to meet the criteria for leukocytosis on 2 consecutive assessments or study completion

Duration of moderate to severe pain (measured in hours)

Score of 4 or greater on the VAS for pain

Randomization

Score of less than 4 on the VAS for pain on 2 consecutive assessments or study completion

Total dose of opioids

Measured in milligram of oral morphine equivalents

Randomization

Study completion

Number of red blood cell transfusions

Number of red blood cell transfusions

Randomization

Study completion

Transfer to the intensive care unit

Yes or no

Randomization

Study completion

Mechanical ventilation

Yes or no

Randomization

Study completion

Multiorgan failure syndrome

Acute development of 2 or more organs or organ systems unable to maintain homeostasis in a critically ill individual

Randomization

Study completion

  1. VAS visual analog scale