Outcome | Outcome definition | Onset | Resolution |
---|---|---|---|
Duration of hospitalization (measured in hours) | Duration of hospitalization | Randomization | Discharge from hospital |
Duration of hypoxemia (measured in hours) | Arterial oxygen saturation less than 90% | Randomization | Failure to meet criteria for hypoxemia on 3 consecutive assessments or study completion |
Duration of fever (measured in hours) | Body temperature greater than or equal to 38.0 °C | Randomization | Failure to meet criteria for fever on 3 consecutive assessments or study completion |
Duration of leukocytosis (measured in hours) | White blood cell count greater than 10,000 per liter | Randomization | Failure to meet the criteria for leukocytosis on 2 consecutive assessments or study completion |
Duration of moderate to severe pain (measured in hours) | Score of 4 or greater on the VAS for pain | Randomization | Score of less than 4 on the VAS for pain on 2 consecutive assessments or study completion |
Total dose of opioids | Measured in milligram of oral morphine equivalents | Randomization | Study completion |
Number of red blood cell transfusions | Number of red blood cell transfusions | Randomization | Study completion |
Transfer to the intensive care unit | Yes or no | Randomization | Study completion |
Mechanical ventilation | Yes or no | Randomization | Study completion |
Multiorgan failure syndrome | Acute development of 2 or more organs or organ systems unable to maintain homeostasis in a critically ill individual | Randomization | Study completion |