Table 4 Sample size assumptions for a clinical trial of corticosteroids for AOM conducted in different settings
Proportion of children | Original assumption [38]a | Middle scenario | Pilot observed resultb |
|---|---|---|---|
With severe AOM | 35% | 56% | 78% |
 With severe AOM AND ongoing pain | 57.5% | 50% | 42% |
With mild AOM | 65% | 43% | 22% |
 With mild AOM AND ongoing pain | 36% | 46% | 57% |
With severe and mild AOM AND ongoing pain | 31.6% | 38.4% | 45.2% |
Sample size calculationc | 760 | 570 | 444 |