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Table 3 Mean scores and change on clinical outcome measures at baseline and follow-up assessments

From: Psychological therapy for mood instability within bipolar spectrum disorder: a single-arm feasibility study of a dialectical behaviour therapy-informed approach

Variable

Baseline, mean (SD)

whole sample

 

Pre-treatment, mean (SD)

ITT/PP sample

Post-treatment, mean (SD)

Pre-post correlation (R)

Effect size (d)

Reliable change (deterioration, no change, improvement)

Six months post-treatment follow-up, mean (SD)

BDI-II

32.75 (11.66)

ITT

30.30 (11.23)

15.60 (10.81)

0.42

1.31

0, 3, 7

21.80 (13.03)

PP

29.67 (11.72)

13.00 (7.45)

0.44

1.42

0, 2, 7

19.78 (12.04)

PHQ9

18.25 (6.34)

ITT

17.50 (6.67)

10.00 (7.09)

0.64

1.12

0, 4, 6

–

PP

16.78 (6.65)

8.56 (5.75)

0.59

1.24

0, 3, 6

GAD7

13.92 (5.47)

ITT

12.90 (5.43)

4.90 (3.18)

0.11

1.47

0, 2, 8

–

PP

13.11 (5.71)

4.89 (3.37)

0.11

1.44

0, 2, 7

BMRS

4.08 (6.40)

ITT

2.40 (2.59)

1.70 (2.54)

0.97

0.27

0, 10, 0

–

PP

2.56 (2.70)

1.89 (2.62)

0.97

0.25

0, 9, 0

ASRM1

3.75 (4.39)

ITT

4.40 (4.55)

5.30 (2.11)

0.36

0.20

2, 6, 2

6.00 (4.27)

PP

4.67 (4.74)

5.67 (1.87)

0.31

0.21

2, 5, 2

6.33 (4.39)

CORE-10

20.08 (6.20)

ITT

19.80 (6.71)

12.30 (7.39)

0.30

1.12

1, 3, 6

–

PP

19.33 (6.95)

10.89 (6.25)

0.21

1.22

1, 3, 5

QoL.BD2

28.91 (8.35)

ITT

30.00 (6.61)

38.67 (7.86)

0.23

1.31

0, 5, 4

34.40 (10.50)

PP

30.50 (6.89)

40.25 (6.69)

0.12

1.42

0, 4, 4

35.44 (10.57)

BDRQ

1877.63 (255.25)

ITT

1910.40 (268.54)

2179.39 (489.33)

0.52

1.00

1, 4, 5

1994.58 (230.13)

PP

1951.14 (249.92)

2240.02 (477.51)

0.55

0.81

1, 4, 4

2022.77 (225.03)

ISS Activation

210.83 (150.12)

ITT

236.00 (148.56)

179.00 (144.03)

0.57

0.38

0, 8, 2

–

PP

252.22 (147.88)

192.22 (146.18)

0.54

0.54

0, 7, 2

ISS Conflict

205.00 (133.52)

ITT

198.00 (128.31)

114.00 (72.60)

0.78

0.65

0, 7, 3

–

PP

195.56 (135.84)

115.56 (76.83)

0.79

0.59

0, 6, 3

ISS Wellbeing

98.33 (67.53)

ITT

108.00 (70.36)

144.00 (87.71)

0.82

0.51

0, 8, 2

–

PP

118.89 (65.09)

157.78 (80.74)

0.74

0.60

0, 7, 2

ISS Depression

109.17 (52.99)

ITT

96.00 (47.19)

66.00 (67.36)

0.57

0.64

1, 5, 4

–

PP

90.00 (45.83)

51.11 (51.10)

0.35

0.85

0, 5, 4

  1. Nine participants completed 6 months post-treatment follow-up
  2. ITT intention-to-treat sample (n = 12), PP per protocol sample (n = 9), BDI-II Beck Depression Inventory—second edition, PHQ9 Patient Health Questionnaire, GAD7 Generalised Anxiety Disorder Scale, BMRS Bech-Rafaelson Mania Rating Scale, ASRM Altman Scale for Rating Mania, CORE-10 Clinical Outcomes in Routine Evaluation Scale, QoL.BD Brief Quality of Life in Bipolar Disorder Scale, BDRQ Bipolar Disorder Recovery Questionnaire, ISS Internal State Scale
  3. 1Completed prior to session 1 of therapy
  4. 2ITT n = 11; PP n = 8
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Pilot and Feasibility Studies

ISSN: 2055-5784