Table 1 Schedule of events

Screening

●

Serum calcium analysis

●*

●

●

Informed consent

●

Randomization

●

Collection of baseline data (demographic, serum metabolic panel, fracture, and surgical data)

●

Nutritional/placebo supplementation**

●

●

●

Assessment of clinical fracture healing (FIX-IT)

●

●

●

●

●

X-rays of tibia or femur

●

●

●

●

●

●

Assessment of radiographic fracture healing (RUST)

●

●

●

●

●

Serum bone marker analysis (CTX and PINP)

●

●

●

Assessment of adherence to supplementation

●

●

Laboratory serum 25(OH)D analysis

●

●

●

Assessment for adverse events

●

●

●

●

●

Serum PTH level analysis

●

●

●

Assessment of fracture healing complications

●

●

●

●

●