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Table 2 Skin necrosis outcome at first occurrence and at 30–40-day follow-up

From: A randomised controlled feasibility trial to evaluate local heat preconditioning on wound healing after reconstructive breast surgery: the preHEAT trial

Necrosis outcome

N control/N heated

Control

Heated

Post-operative skin necrosis (n, %)

66*/68**

  

 No

43 (65%)

50 (74%)

 Yes

23 (35%)

18 (26%)

Depth of necrosis at first occurrence (n, %)

62/64

  

 A—none

44 (71%)

50 (78%)

 B—colour change

11 (18%)

9 (14%)

 C—partial thickness

7 (11%)

4 (6%)

 D—full thickness

0 (0%)

1 (2%)

Area of necrosis at first occurrence

 Total area if necrosis present (mm2)

18/14

  

  Median (IQR)

850.0 (100.0, 2700.0)

700.0 (400.0, 1300.0)

By SKIN score

 Area of colour change (mm2)

11/9

  

  Median (IQR)

300.0 (50.0, 1020.0)

700.0 (600.0, 1300.0)

 Area of partial thickness (mm2)

7/4

  

  Median (IQR)

1500.0 (250.0, 3300.0)

730.0 (355.0, 2050.0)

 Area of full thickness (mm2)

0/1

  

  Median (IQR)

 Total area for all patients (including area = 0 mm2 for none)

61/64

  

 Median (IQR)

0.0 (0.0, 50.0)

0.0 (0.0, 0.0)

Maximum depth of necrosis over 30–40-day follow-up (n, %)

62/64

  

 A—none

44 (71%)

50 (78%)

 B—colour change

10 (16%)

9 (14%)

 C—partial thickness

6 (10%)

3 (5%)

 D—full thickness

2 (3%)

2 (3%)

Maximum area of necrosis over 30–40 day follow-up

 Total area if necrosis present (mm2)

18/14

  

  Median (IQR)

850.0 (100.0, 2700.0)

700.0 (400.0, 1300.0)

By SKIN score

 Area of colour change (mm2)

11/9

  

  Median (IQR)

485.0 (50.0, 1020.0)

700.0 (600.0, 1300.0)

 Area of partial thickness (mm2)

7/4

  

  Median (IQR)

1800.0 (250.0, 3300.0)

1000.0 (250.0, 3100.0)

 Area of full thickness (mm2)

0/1

  

  Median (IQR)

(−)

(−)

 Total area for all patients (including area = 0 mm2 for none)

61/64

  

  Median (IQR)

0.0 (0.0, 50.0)

0.0 (0.0, 0.0)

Necrosis resolved/fully healed within 30–40-day follow-up (n, %)

17/13

  

 No

 

8 (47%)

7 (54%)

 Yes

 

9 (53%)

6 (46%)

  1. *Necrosis outcome missing for n = 1 patient in control group who had SRM. The remaining n = 3 control patients without the necrosis outcome withdrew prior to surgery. **Necrosis outcome missing for n = 2 patients in heated group who had NSM or mastectomy only. The remaining n = 1 heated patient without the necrosis outcome withdrew prior to surgery. All measurements reported here by primary clinical assessor