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Table 1 Outcome measures

From: A protocol for a randomised double-blind placebo-controlled feasibility study to determine whether the daily consumption of flavonoid-rich pure cocoa has the potential to reduce fatigue in people with relapsing and remitting multiple sclerosis (RRMS)

Domain to be measured Outcome measure(s) Time required When
Measures of overall health and questionnaires
 1. Health questionnaire and health assessment General medicine use/health problems, etc. 10 min 1
 2. Global fatigue Neuro quality of life 5 min 1, 2, 3
 3. Limitations in daily activity Barthel Activities in Daily Living Index 5 min 1
 4. Quality of life measure EuroQOL 5D5L and Problem Based Multiple Sclerosis Index 5 min 1, 2, 3
 5. Dietary recall Monitor diet patterns 10 min 1, 2, 3
 6. Consent Verbal followed by written 10 min 1
 8. Speed of information processing The Adult Memory and Information Processing Battery 5 min 1, 2, 3
 9. Depression Hospital Anxiety and Depression Scale 5 min 1, 2, 3
 10. Physical activity Physical Activity Survey for the Elderly 10 min 1
 11. Fatigue Fatigue Severity Scale 5 min 1
Measures of activity and fatigue
 11. 6-min walk Fatigue 6 min 1, 3
 12. Accelerometer Activity 2 weeks and 3 days throughout intervention
 13. Numerical Rating Scale for fatigue Fatigue 3 times daily for 6 weeks
Measures of plasma markers
 14. Venous blood samples Inflammation, oxidative stress, antioxidant capacity of plasma 5 min 1, 2, 3
  1. 1 = baseline assessment; 2 = assessment 2 (3 weeks); 3 = assessment 3 (6 weeks)