Table 1 Outcome measures
Domain to be measured | Outcome measure(s) | Time required | When |
|---|---|---|---|
Measures of overall health and questionnaires | |||
 1. Health questionnaire and health assessment | General medicine use/health problems, etc. | 10 min | 1 |
 2. Global fatigue | Neuro quality of life | 5 min | 1, 2, 3 |
 3. Limitations in daily activity | Barthel Activities in Daily Living Index | 5 min | 1 |
 4. Quality of life measure | EuroQOL 5D5L and Problem Based Multiple Sclerosis Index | 5 min | 1, 2, 3 |
 5. Dietary recall | Monitor diet patterns | 10 min | 1, 2, 3 |
 6. Consent | Verbal followed by written | 10 min | 1 |
 8. Speed of information processing | The Adult Memory and Information Processing Battery | 5 min | 1, 2, 3 |
 9. Depression | Hospital Anxiety and Depression Scale | 5 min | 1, 2, 3 |
 10. Physical activity | Physical Activity Survey for the Elderly | 10 min | 1 |
 11. Fatigue | Fatigue Severity Scale | 5 min | 1 |
Measures of activity and fatigue | |||
 11. 6-min walk | Fatigue | 6 min | 1, 3 |
 12. Accelerometer | Activity | 2 weeks and 3 days throughout intervention | – |
 13. Numerical Rating Scale for fatigue | Fatigue | 3 times daily for 6 weeks | – |
Measures of plasma markers | |||
 14. Venous blood samples | Inflammation, oxidative stress, antioxidant capacity of plasma | 5 min | 1, 2, 3 |