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Table 5 Maximum value of immune factors measured in sequential peripheral blood plasma samples collected at 24-h and 7-day post doses 1, 2, 3, or 4

From: Evaluation of neurological changes in secondary progressive multiple sclerosis patients treated with immune modulator MIS416: results from a feasibility study

 

Patient ID

Immune factor (pg/mL)

DC

DC

DC

DC

DC

DC

DC

DC

DC

DC

DC

1

2

3

5

6

7

9

10

11

12

14

CD62E

18,503

33,350

16,905

21,510

18,458

37,502

19,729

20,984

27,616

18,471

8447

Fractalkine

531

907

421

458

434

350

492

308

397

143

373

GCSF

28

24

29

25

26

30

24

27

25

21

26

ICAM1 x104

70

74

51

38

64

145

59

48

66

21

40

IFN-γ

178

281

147

74

73

192

76

48

52

0

122

IL-10

11

19

12

8

7

27

10

7

11

5

29

IL11

322

423

2540

3194

19

0

179

808

168

1522

60

IL12p40

339

321

182

291

292

185

60

183

65

136

177

IL1RA

6693

7696

5797

6315

3939

18,299

18,709

8070

6858

2721

4965

IL6

36

47

181

22

32

87

81

19

23

11

140

IP10

3640

5371

6089

2812

3068

7689

4240

1646

2704

1234

1395

MCP-1

163

722

889

432

330

296

385

187

255

704

465

MIG

9766

111,584

13,706

24,823

5444

18,058

16,966

7520

2780

1514

2989

MIP1-α

4

9

6

5

8

4

5

5

5

6

9

Neopterin

5237

3378

3486

2244

4221

3927

3850

3728

3891

2060

2658

PGE2

182

219

157

160

192

212

343

398

296

207

32

RANTES

255,145

174,684

189,866

231,938

166,300

257,508

353,761

229,399

265,178

167,513

119,622

TGF-β

6034

5973

3394

3872

4699

6542

6291

11,851

8124

8236

5047

TNF-R

4850

5230

5060

4560

7870

3680

2970

2450

1930

5210

2510

VCAM-1

972,534

761,399

970,295

1,047,583

1,300,968

889,864

672,495

1,056,576

467,492

936,152

828,607

VEGF

116

67

28

37

76

45

144

88

80

81

9