• Significant dose of vasoactive agents (e.g. >0.2 mcg/kg/min noradrenaline or equivalent) |  |
• Mechanically ventilated with FiO2 >0.6 and/or PEEP >12 cmH2O or acutely worsening respiratory failure |  |
• Acute neurological event |  |
• Unstable spine or extremity fractures with contraindications to mobilise |  |
• Active bleeding process |  |