Inclusion criteria (all criteria must apply): • Women with a pathogenic BRCA1 or BRCA2 germline mutation • Age between 18 and 69 years • Written informed consent |  |
Exclusion criteria: • Metastatic tumor disease • Expectancy of life <3 years • Limited cardiovascular and lung diseases (instable CHC, heart failure stage IV, COPD GOLD IV, maximal blood pressure at rest >160/100 mmHg) • Significant orthopedic problems, not allowing exercise • Serious diseases, not allowing a participation in group interventions (e.g., psychiatric or internal ailment) • Karnofsky status scale <60% • Women with VO2 max > 150% of general population • Women with an exercise capacity <50 W • Food allergies not allowing consumption of a Mediterranean dietary pattern • Vegans • BMI < 15 kg/m2 • Pregnancy • Insufficient knowledge of the German language • Current participation in other lifestyle intervention trials |  |