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Table 4 National Danish UTI treatment recommendations

From: Exploring the feasibility and synergistic value of the One Health approach in clinical research: protocol for a prospective observational study of diagnostic pathways in human and canine patients with suspected urinary tract infection

  General practice [38] Veterinary practice [39]
Acute uncomplicated cystitis
 First-line antibiotics * Sulfamethizol 1 g × 2 for 3 days * Amoxicillin 10–15 mg/kg, PO, BID–TID ≤7 days
* Pivmecillinam 400 mg × 3 for 3 days * Sulfa/TMP 15 mg/kg, PO, BID ≤7 days
 Second-line antibiotics * Trimethoprim 200 mg × 2 for 3 days * Amoxicillin/clavulanic acid 12.5–25 mg/kg, PO, BID–TID ≤7 days
* Nitrofurantoin 50 mg × 4 for 3 days * Enrofloxacin 5 mg/kg IM/SC/PO, SID ≤7 days
Acute complicated cystitis
 First-line antibiotics * Sulfamethizol 1 g × 2 for 3 days * Amoxicillin 10–15 mg/kg, PO, BID–TID 7 days to 4 weeks
* Pivmecillinam 400 mg × 3 for 3 days * Sulfa/TMP 15 mg/kg, PO, BID 7 days to 4 weeks
 Second-line antibiotics * Trimethoprim 200 mg × 2 for 3 days * Amoxicillin/clavulanic acid 12.5–20 mg/kg, PO, BID–TID 7 days to 4 weeks
* Nitrofurantoin 50 mg × 4 for 3 days * Enrofloxacin 5 mg/kg IM/SC/PO, SID 7 days to 4 weeks
Acute pyelonephritis
 First-line antibiotics * Pivmecillinam 400 mg × 3 for 3 days * Amoxicillin/clavulanic acid 12.5–25 mg/kg IM/SC/PO, BID–TID 4–6 weeks
 Second-line antibiotics * Ciprofloxacin 500 mg × 2 for 10 days * Enrofloxacin 5–20 mg/kg IM/SC/PO, SID 4–6 weeks