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Table 1 Modifiable risk factors and conditions identified by In-MINDD as potentially increasing or reducing dementia risk (adapted from [12])

From: Reducing dementia risk by targeting modifiable risk factors in mid-life: study protocol for the Innovative Midlife Intervention for Dementia Deterrence (In-MINDD) randomised controlled feasibility trial

Risk/protective factor Relative risk from published literature Weight applied to factor for LIBRA global score
Low/moderate alcohol consumption 0.74 −1.0
Coronary heart disease 1.36 +1.0
Physical inactivity 1.39 +1.1
Renal dysfunction 1.39 +1.1
Diabetes 1.47 +1.3
Raised cholesterol level 1.54 +1.4
Smoking 1.59 +1.5
(Midlife) obesity 1.60 +1.6
(Midlife) hypertension 1.61 +1.6
Mediterranean diet 0.60 −1.7
Depression 1.85 +2.1
Cognitive activity 0.38 −3.2